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Old 04-08-2004, 02:34 AM
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Quote:
Originally Posted by demeurj
I wouldn't be surprised in Winny prevents the some progestin-like activity of deca/fina. My guess would be competitive inhibition of 5-alpha reductase; with the androgenic potential of Winny being much less than deca/fina. Furthermore, the aromatization of deca/fina is also enzyme mediated but likely one of the liver cytochromes not typical aromatase activity. That means that something as simple as grapefruit juice might increase or decrease the anabolic (and side effects). Another option is that Winny acts like Clomid. The androgenic effects of Winny are so weak in comparison to Deca/Fina that it essentially blocks the activity.

I had no idea people were using chasteberry for gyno. Last I heard it was almost useful for PMS. I saw one reference that said it binds to the estrogen receptor and stimulates the PRODUCTION of progesterone receptors but it doesn't activity the progesterone receptor. So it's conceivable that chasteberry may block the estrogen and progesterone receptors.

Exemestane can have a negative influence on estrogen and boost HDL at the same time by acting through different pathways. Although estrogen is important for HDL it clearly isn't the sole determinant of HDL. In fact, Pfizer has a drug in development that has doubled HDL levels in early trials.

Thanks again......you know that if you keep answering my questions....I'm just going to keep coming back to you with more.
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