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Originally Posted by Heretic Credit to the gods that wrote this... 
HOW TO NOT FUCK UP DNP: |
Hey bro I appreciate your evidence for
DNP however I was a little concerned by the spec sheet for the antibody for DNP as an antidote. Antibodies aren't antidotes; they do however have an integral part in the adaptive immune response. This is done by immature B-cells in the bone marrow being selected for affinity for an antigen. Once selection has taken place the B-cell becomes a plasma cell secreting antibodies specific for the antigen. The way the antibody can kill/remove the antigen is to be recognized by a T-helper cell which is MHC-restricted. Then programmed death (apotosis) can occur. The antibody on the spec sheet is made from a host other than human which means that if you introduced this Ig into a human the host will recognize this as foreign and build an immune response to it. Also if the foreign Ig is able to bind DNP in the host it would not allow program cell death because the T-helper cell has to be MHC restricted meaning that it will not recognize anitigen that is in the binding pocket of the major histocompatibility complex. That's all I have to say about that but I would like to try some DNP, maybe pm me so that I can get some, Thanks