08-04-2004, 08:36 PM
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 | Senior Member | | Join Date: Dec 2003 Location: USA
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Originally Posted by Joker Not the case--I have never seen anything about biotin increasing the effectiveness of lipoic acid. The reason it's in there is because they are structurally similar, and as such, when taking lipoic acid it can reduce the activity of biotin in vivo. I know there is a study out there that was done in the late nineties that did, in fact, show some reduction in biotin activity combined with ALA supplementation. But the doses of ALA used to garner this effect were excessive to the point that no human would ever (in his or her right mind) consume such an amount. And even in such cases, they were shown to be 100% reversible with simple biotin supplementation. Additionally, the reduced biotin activity did not suppress enzyme activity (i.e. pyruvate kinase) to the point of causing any notable dysfunction even without adding supplemental biotin to supra-physiologic dosages.
The reason the biotin is in there is to counteract this potential, yet improbable, threat--nothing more.
Joker | Not sure if this is the study you are referring to or not, but it pretty much states exactly what you said. http://www.ncbi.nlm.nih.gov/entrez/q...t_uids=9278559  |