The info below is not my own, but coppied from the Web:
Progesterone induced gyno a misconception?
To cear up a few misconceptions about progesterone and gynecomastia.
Their is absolutely no steroid that aromatizes into progesterone. The reason for this is that progesteron does not have an aromatic A ring. So toss that myth out the window.
Tren? Deca? Sorry but it just doesn't happen.
Trenbolone \ Deca bind pretty well to the
PR. They are progestins in their own right without undergoing structural changes, but their affinity is MUCH weaker than progesterone itself. Even more so when nandrolone is reduced by 5-alpha reductase into DHN. Their is a small chance of progestogenic activity that could aid in manifesting a mass in the mammry IF estrogen is present in supraphysiological amounts, without proper ratio to
testosterone but I have never see a documented case of progestogenic gynecomastia. The reason for this is that the
PR has two isoforms. The
PR-A and
PR-B.
PR-B mediates stimulatory effects of progestins;
PR-A which is bound with progestins or anti-progestins inhibits
PR-B, and
PR-A is dominant,. The response to progesterone is determined by the relative expression of the two isoforms.
There is a direct relationship between the
PR isoforms and steroid concentrations an this direct relationship suggests high progesterone concentrations, but this will induce the expression of
PR-A, which represses transcription of
PR-B, which in turn supresses
PR function and progestin effect
With initial administration of nandrolone or it's dirivitives, I could see an expression of
PR-B but a rapid rise in
PR-A will ultimately supress the function of the
PR. IMO, you would need a high ratio of the two before concerns, and this is a bit more of a possiblity with the begining of administration. In this time of vulnerability, rest assured in aromatase inhibitors as progesterone is an E2 agonist so the utilization of an AI will help. I personally don't think the concern is warranted though
Their are 4 combinations of hormones that cause gyno- Estrogen, Progesterone, Prolactin, and
IGF. Nandrolone is a weak progestin, which agonizes the PRL, it also raises
IGF. Progesterone induced gyno is not really of a concern given binding affinity to the
PR and the mechanism of the two isoforms. The production of prolactin is a deffinate risk. Not only can it be an inductor for gyno along side estrogen, IGF, and pogesterone; this chance is increased as prolactn lowers
testosterone. So you need to make sure to take proper precautions to not only keep estrogen in check, but prolactin as well.
bromo is a prolactin inhibitor, as it's a dopamine agonist. Dopamine regulates prolactin. Bromo, dostinex, pergolide, and alike drugs have no direct effect over progesterone
Just to add. B6 is the safest way to help control prolactin. This is recommended before taking the step to a power drug like bromo.
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