Thank you for taking the time to respond.
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Originally Posted by hooker Pharmacokinetics of anastrozole and tamoxifen alone, and in combination, during adjuvant endocrine therapy for early breast cancer in postmenopausal women: a sub-protocol of the 'Arimidex and tamoxifen alone or in combination' (ATAC) trial. |
Hmmmmm.... I missed this one. I apologize.
Do you have evidence that exemstane does not interact with tamoxifen?
Any opinions on formestane or ATD?
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| Successfull? Maybe. Optimal? No. |
I'm confused. Is your proposed goal complete suppression of estrogen/aromatase? Wouldn't that potentially cause health problems we normally aim to avoid? Or is this period of total suppression so brief that the potential health problems are a non-issue?
Now, the following abstract is not very clear with it's wording, but the significant impact vitamin E had in this study may be significant because it was a deficiency model. It might not be a deficiency model, but I don't know that without seeing the full text.
If you have a copy of the full text, would you mind emailing it to me?
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Effect of vitamin E on function of pituitary-gonadal axis in male rats and human subjects.
The role of vitamin E in the endocrine system, in particular the pituitary-gonadal axis, was studied in humans and male rats by examining the hormonal differences between vitamin E deficient and supplemented conditions. In vitamin E deficient rats, pituitary content and basal plasma level of FSH and LH were significantly lower than those of the control rats, but testicular content and basal plasma level of testosterone were not significantly changed. On the other hand, in vitamin E supplemented rats, FSH and LH content in pituitary tissue was significantly higher than that of the controls, but there was no significant rise in basal FSH and LH level in plasma. The testosterone level was significantly elevated in both testicular tissue and plasma. It was also demonstrated that basal plasma testosterone and F.T.I. were increased in normal male subjects following oral vitamin E administration and the responsiveness of plasma testosterone levels to HCG was significantly higher during vitamin E administration than before administration. These results suggest that vitamin E may play an important and potent role in hormone production in the pituitary-gonadal axis in humans and rats.
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I look forward to reading more of your articles, as well as your up-coming book. Thanks again.