Here are some more studies that seem to suggest that a smaller application area for
Testosterone Gel/Cream should lead to lower
DHT and Estrogen conversion.
http://jcem.endojournals.org/cgi/con.../89/8/3821#R18
When transdermal T gels are applied to a large area of skin, higher serum
DHT/T ratios have been reported, although the increase is considered not to be clinically significant (20, 21). This may be due to the presence of 5- -reductase in the skin that may result in greater conversion of T to
DHT and the larger skin area that is exposed to the gel on administration, compared with other topical formulations, or to TBS (18, 19).
http://jcem.endojournals.org/cgi/con...18c23053cb5 e
T gel application resulted in mean serum
DHT that tripled after application of 50 mg T gel and rose nearly 5-fold with 100 mg T gel treatment. As 5 -reductase is present in nongenital skin (25), the increase in
DHT/T ratios in the 100 and 50 mg gel groups could be explained by the higher conversion in the skin of T to
DHT as a result of the large area of skin surface exposed to T in the gel groups compared with the very small area of skin exposed to the T patch.