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Originally Posted by zadok My FT level will not raise above the bare minimum, TRT, or no TRT. TT can be v high, but FT is always v low. It is not Estrogens causing the prob cause i have eliminated that. SHBG is v.v low also. Scientifically, the test must be going somewhere, or binding to something else, which must be high. My question is what else does test bind to? My Albumin is high normal 46nmol/l (35-50), however i dont think that would be causing this problem, what else could it be? |
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testosterone consists of:
1. Testosterone strongly bound to Sex Hormone Binding Globulin - inactive
2. Testosterone weakly bound to Albumin - potentially active
3. Testosterone which is free - fully active
Measuring Bioavailable
Testosterone (free and weakly bound) is important when questioning the effectiveness of
TRT, if free T is low.
Albumin makes up about 70% of the circulating protein in the blood. It is highly important to maintain blood pressure and to transport other substances.
By weakly binding Testosterone, Albumin protects Testosterone from being destroyed in the liver. Free Testosterone itself may last only about 70 minutes before being destroyed. Testosterone bound to Albumin may be considered the body's way to create a natural extended-release form of testosterone - just as medications often come in an extended-release version.
High albumin level is primarily associated with dehydration.
Dehydration and high albumin level is one possible clue that adrenal fatigue or insufficiency is occurring. In adrenal fatigue or insufficiency, besides cortisol and DHEA, not enough aldosterone is produced. Aldosterone is important in maintaining sodium level, fluid and salt balance in the body, maintaining blood pressure.
Adrenal fatigue or insufficiency may contribute to sexual dysfunction (and other conditions) and can lower testosterone production.