Quote:
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Originally Posted by KidCapriB bump...this is an important thread for the good of everyone here. |
One problem that I see, (and I am not a doctor),
people are told to watch Total
testosterone levels and keep them in upper third for their age.
Good for some by accident, better then no
Testosterone at all.
What body sees is FreeT and BioavailableT.
That is not the same thing, two reasons.
1. even when people ask for them on the blood
test, usually in return they get garbage, see this
http://jcem.endojournals.org/cgi/reprint/86/6/2903.pdf
Only Quest Diagnostic, that I know of, do them the right way, that is, calculate them from
TT, Albumin and SHBG that they get from the same blood draw.
See under Method: Free, Bioavailable, and Total
Testosterone http://www.questdiagnostics.com/hcp/...one_LCMSMS.htm
ranges, (right two columns)
http://www.questdiagnostics.com/hcp/.../Table%201.pdf
Probably good idea to be close to the top but not exceed nether range or excessive E2 and
DHT happens.
One can also do the calculation using:
http://www.issam.ch/freetesto.htm http://www.get-back-on-track.com/en/tools/umrechner.php
note that that calculator is "old" since it is based on 1999 paper,
See disclaimer when pregnant or using transdermal
DHT.
2. See also 2006 work:
Impact of recent biochemical findings on the determination
of free and bioavailable testosterone: evaluation and
proposal for clinical use (remove red dashes).
http
---------://www.atypon-link.com/WDG/doi/pdf/10.1515/JLM.2006.050
If anyone is able to work this into more convenient calculator, please do and share.
But it is anoter reason for possibly missing the mark , even when trying to be careful.
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Check LabCorp, they do "Methodology
Ammonium sulfate precipitation; radioassay " rather than calculation.
http://labcorp.com/dos/index.html
under letter T, then
Testosterone, Free and Weakly Bound
also here, good read but the do not calculate, they all kind of other things.
http://www.labcorp.com/cme/pdf/CME_T...ticle_1167.pdf
"Since men with hypogonadism often have high SHBG levels,
the measurement of free or bioavailable testosterone has
been advocated when total testosterone levels are normal in
men with symptoms of androgen deficiency."
Also:
"METHODS FOR MEASURING TESTOSTERONE
Many clinicians and laboratorians are confused about the most appropriate
method for “measuring testosterone status.”4,5,22 There
are numerous schools of thought as to which form of the hormone
should be measured and which analytical method provides the most accurate
assessment of biological activity. Since there is not a clear consensus
on this issue, it is important, at least, to understand the analytical basis for
the various methods available. Some of the different approaches currently
used for measuring testosterone status include (1) total testosterone, (2)
androgen index calculation, (3) free testosterone by equilibrium dialysis
or equilibrium ultrafiltration, (4) free testosterone by analog tracer immunoassay,
(5) bioavailable testosterone and (6) salivary testosterone.
Each is described below."
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I am hoping that with testosterone level at levels driven by FreeT and BioAvailableT there should be much lesser problem with E2 and
DHT management.
There is this thing, DIM we have to keep eye on, not only good for E2 but also for
DHT.
I just started googling DIM, but found (not read yet),
http://www.dimfaq.com/index.htm
he says that not all DIM's are the same, hmmm.
but LEF recomends one pill of this
http://www.lef.org/newshop/items/item00855.html
for up to 160# body weight, I am 160# but recently increased to two pills and I think it works better.
Phil uses Indolplex and it works.
http://www.ritecare.com/prodsheets/PHY-15336.html
but some other DIM products do not work.