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Originally Posted by newscandinavian Just thought I'd add to this with an interesting piece of info I came across on Melatonin. |
I view this study as either garbage or a warning to Not take Melatonin.
1. The supposed increase in
GH Does Not increase
IGF-1 levels. Big warning here as
GH's effects are partially, if not largely, mediated through
IGF-1. Any increase in
GH should correspondingly increase IGF-1... in fact, the most common
test for
GH levels is actually a
test for IGF-1 levels. So I view any supposed increase in
GH, without an increase in IGF-1, as very suspect.
2. The increase in IGF-BP3 is bad news. This stands for IGF-Binding Protein 3. The is the BP that attaches and binds IGF-1. So if there's an increase in IGFBP3, the circulating IGF-1 you do have, is now being bound up at an even higher rate. Which is bad news because it means it can't bind to the IGF-1 receptors, and do all the good things, like satellite cell activation and enhanced protein synthesis, that IGF-1 does.
Best regards,
MaxRep