Also, in regards to my upcoming trail with baclofen, we only hope that it increases LH. I say that because the main objective is to confirm or deny that baclofen stops or reverses T negative feedback with an added bonus that it also increases LH.
In other words, as long as LH stays the same and doesn't decrease as a result of T negative feedback, that's a major accomplishment. within itself as that would ensure T users that the little guys aren't getting any smaller as a result of T negative feedback.
The majority of the studies do confirm the
GH increase, however, there are conflicting studies regarding the LH attributes of baclofen.
My theory on why this conflict may exist is that some of the older studies were with baclofen before newer delivery methods crossing the BBB were possibly incorporated in the drug. However, in my research of the drug, I must admit that this is highly speculative because I'm still not completely satisfied with some of the answers I've been getting as to how effectively baclofen crosses the BBB.
However, I tend to believe/hope that because it is widely accepted that baclofen increases
GH and
GH is sythesized in the anterior pituitary gland of which, is under the influence of the hypothalamus, that there is a good chance the baclofen studies concluding bac raises LH are correct ,as coincidentally GnRH of which is responsible for releasing FSH and LH is also under the influence of the hypothalamus.
Although there are many more complex factors involved IMO, the aforesaid, lends support to the hypothesis that bac may indeed increase LH and FSH or at the very least it's reasonable to conclude it effectively crosses the BBB otherwise, one would think it would not so effectively increase
GH.
http://en.wikipedia.org/wiki/Blood-brain_barrier http://en.wikipedia.org/wiki/Anterior_pituitary http://en.wikipedia.org/wiki/Growth_hormone http://en.wikipedia.org/wiki/Gnrh