[Jtay]

Known Baclofen Drug Interactions:

"Increased sedation may occur if baclofen is taken with agents acting on the central nervous system, alcohol or synthetic opiates. The risk of respiratory depression is also increased.

Combined treatment with baclofen and antihypertensives is likely to increase the fall in blood pressure; therefore the dosage of antihypertensive medication should be adjusted accordingly.

The concomitant administration of baclofen and tricyclic antidepressants may potentiate the pharmacological effects of baclofen resulting in pronounced muscular hypotonia.

In patients with Parkinsons disease receiving treatment with baclofen and levodopa plus carbidopa there have been several reports of mental confusion, hallucinations, headaches, nausea and agitation.

The concurrent use of MAO inhibitors and baclofen may result in increased CNS depressant effects. Caution is advised and the dosage of one or both agents should be adjusted accordingly.

Caution should be exercised when administering baclofen and magnesium sulphate or other neuromuscular blocking agents since a synergistic effect may theoretically occur."