Quote:
Originally Posted by zkt  " Is it true that ejaculation converts Dopamine to NE? Sex without ejaculation would
increase DA without increasing NE? "
Not sure if ejaculationn converts DA to Norepi but the PRL surge inhibits DA synthesis. Tanatric Buddists would practice sex without ejaculation for months at a time as have I in the past. It does tend to energise one. |
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It seems too suggest below for POIS sufferers that there is an exccessive conversion of DA too NE+NOE and many other things..Although Iam not sure how accurate the articles below are but it be very good if Dr Marianco could have a look at it.
Only 5 years of POIS for me since age 19 plus Peyronies Disease since 15-16 young. Iam not able physically too have sex ever from the severe PD that I have and if I do ejaculate it causes POIS symptoms for days. Although not as bad as some people which can last 30 days.
It is amazing how all of my supposely prime years are really wasted away due to this POIS. I would pay all my money too cure this POIS and take out big loans if need be, dont care how much it cost and if I would have too spend the rest of my life financially poor , it would be very much worth it.
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Destruction of Excessive Orgasms
After you enjoyed too many sexual orgasms and/or too much pleasure, you have likely blown your brain/nervous bioelectric circuit breaker, and may have started to deal with the Sexual Exhaustion Symptoms - the exhaustion of the hypothalamus-pituitary-adrenal/-testicular axis, very possibly or likely including the hypothalamus-pituitary-thyroid dysfunction, and deducing/downgrading or desensitization of the androgen hormonal receptors in the hypothalamus, hippocampus and pituitary, resulting from the Nervous Excitotoxicity and Inflammation induced by excessive norepinephrine, epinephrine and glutamate (& other excitory neurohormones, for a short-term pleasure reward and the long-term dopamine depletion), long-term excessive elevation of prolactin ( to inhibit GnRH release from the hypothalamus and therefore LH and FSH secretion from the pituitary and to directly desensitize pituitary gonadotropic cells and the Leydig cells of the testes) , and Prostaglandin E2 (the brain heater for the core temperature rise!) At the sexual exhaustion state, the constant elevation of excessive prolactin (mimics Hyperprolactinaemia) suppress sensitivity of prolactin-negative feedback on hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons for persistently low dopamine synthesis, blocks the beta-adrenergic receptors and nitric oxide nervous mechanisms and promotes norepinphrine and epinpehrine binding to the alpha-adrenergic receptors for vasoconstriction and restriction of blood flow to the brain and genitals, and destroys or desensitizes the hypothalamic androgen receptors, as described in
Mechanisms underlying {beta}2-adrenoceptor-mediated nitric oxide generation by human umbilical vein endothelial cells -- Queen et al. 576 (2): 585 -- The Journal of Physiology Online 16-kDa Prolactin Down-Regulates Inducible Nitric Oxide Synthase Expression through Inhibition of the Signal Transducer and Activator of Transcription 1/IFN Regulatory Factor-1 Pathway -- Lee et al. 65 (17): 7984 -- Cancer Research 16K-Prolactin Inhibits Activation of Endothelial Nitric Oxide Synthase, Intracellular Calcium Mobilization, and Endothelium-Dependent Vasorelaxation -- Gonzalez et al. 145 (12): 5714 -- Endocrinology Prolactin Induces Regional Vasoconstriction through the {beta}2-Adrenergic and Nitric Oxide Mechanisms -- Molinari et al. 148 (8): 4080 -- Endocrinology Wiley InterScience :: Session Cookies http://www.psy.fsu.edu/faculty/hull/D&H_review.pdf The role of nitric oxide in the peripheral vasoconstriction caused by human placental lactogen in anaesthetized pigs -- Molinari et al. 91 (3): 603 -- Experimental Physiology The effect of dehydroepiandrosterone on regional blood flow in prepubertal anaesthetized pigs -- Molinari et al. 557 (1): 307 -- The Journal of Physiology Online Mechanisms Underlying the Diminished Sensitivity to Prolactin Negative Feedback during Lactation: Reduced STAT5 Signaling and Up-Regulation of Cytokine-Inducible SH2 Domain-Containing Protein (CIS) Expression in Tuberoinfundibular Dopaminergic Neuron
Cutting down the brain and genital blood circulation naturally alternates the neurotransmitters and hormonal syntheses, the major brain nervous function including the dopamine, acetylcholine, serotonin, GABA, noradrenergic, adrenergic, glutamate, oxytocin, nitric-oxide(NO), vagal and autonomic nerves functions, and the hypothalamus-pituitary-adrenal and -testicular(-ovarian) function.
The Traditional Chinese Medicine has termed the hypothalamus-pituitary-adrenal (HPA) exhaustion as "Kidney Deficiency", since the classic Chinese anatomy text assumed the tiny adrenal gland, sitting on the top of the kidney, is a part of the kidney about 2000 years ago. The HPA exhaustion results in the erratic release of CRH (corticotropin releasing hormone), POMC (proopinomelanocortin), ACTH (adrenocorticotropc hormone), ß-lipotropic hormone, ß-endorphin, α-melanocyte-stimulating hormone (α-MSH), ß-MSH, CA (catecholamines) and TSH (thyroid stimulation hormone), in response to stress, sex and environmental/dyshomeostatic stimuli. Since skin and hair follicles also display a functional equivalent of the HPA axis, sexual exhaustion will also extensively affect your skin (for examples: darkening skins in certain areas such as eye cycles, nips, labia minors, foreskin, perineum and groins, due to excessive release or trapping of the POMC peptide α-MSH which is also an anti-inflammatory and immunomodulating hormone - anti-tissue abrasion!) and the hair (for examples: hair loss in the scalp and gray hair, but it won't grow hair in your palms although it will destroy your HPA axis.) The explanation of the HPA, skin and hair connection are given in the following links:
Neuroendocrinology of the Skin -- Slominski and Wortsman 21 (5): 457 -- Endocrine Reviews,
http://www.pubmedcentral.nih.gov/pic...6&blobtype=pdf ,
http://www.fasebj.org/cgi/reprint/04-1968fjev1.pdf,
http://www.tufts.edu/sackler/pharmac...brain-skin.pdf ,
Corticotropin Releasing Hormone and Proopiomelanocortin Involvement in the Cutaneous Response to Stress -- Slominski et al. 80 (3): 979 -- Physiological Reviews ,
{alpha}-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs -- Luger and Brzoska 66 (3): iii52 -- Annals of the Rheumatic Diseases ,
Alterations in hypothalamic-pituitary-adrenal axis...[Brain Res. 2003] - PubMed Result ,
http://www.fasebj.org/cgi/reprint/19/10/1332.pdf,
The Skin POMC System (SPS): Leads and Lessons from the Hair Follicle -- PAUS et al. 885 (1): 350 -- Annals of the New York Academy of Sciences , and
JCI - A nervous breakdown in the skin: stress and the epidermal barrier
As a result, sex is like a good investment with a bad return. When you reach the neuro-endocrine breaking point, it is like the stoke market cash leading to the great depression!! Yes, excessive sex induces psychological and physiological disorders.