Hi there,
I recently tested quite a bit over range for estradiol. I am hypothyroid and have adrenal fatigue, so i am on thyroid and hydrocortisone.
Many sources link high estradiol and high CBG. This article that stated that treatment with estradiol 'resulted in significant increases from baseline in SHBG, TBG and CBG'
Ref ;
Effects of transdermal and oral contraceptives on estrogen-sensitive hepatic proteins Contraception , Volume 74 , Issue 4 , Pages 293 - 296.
Elsevier Article Locator
Also this site (
"High CBG Addison's Disease"Copyright ©2006 Mike Welch ) indicates a link between high Cortisol Binding Globulin and addisons disease!
So basically what im wondering is if the cause for my weak adrenals is my high estradiol?
Once cortisol gets bound to CBG is it rendered completly inactive or is it just in reserve for use when it is needed?
What about SHBG and TBG, do these render
testosterone and thyroid inactive? If they do what is the role of these Binding Globulins in the body?
Thanks...