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Old 10-01-2008, 10:16 PM
thenxtgrt1 thenxtgrt1 is offline
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Default Re: [PIC] Steroidogensis Pathway... why am I bottlenecked?

Quote:
Originally Posted by krazy View Post
Ok, last thread on this, I promise. I'm getting treatment in a few weeks but I want to make one last effort before I get chalked up to being idiopathic.

Steroidogensis Pathway (c/o Wikipedia):


Related stats:
Pregnanediol: 500 (32-501) - Progesterone metabolite
DHEA: 3032 (5-1476) (No, I don't supplement DHEA, either)
Androstenedione: 53 (0-50)
Estrone: 2.2 (3-12.0)
Androstanediol: 85 (48-578)
Testosterone: 35 (60-103)
Estradiol: 0.5 (0-7.0)
DHT: 9.4 (0-13)
(This was from a urine test on 08/03)


Interesting numbers from earlier labwork:
04/29: LH: 1.3 (1.5-9.3) - out-of-range low
DHEA-S: 293 (110-510) - now in range??
Estradiol: 31 (<= 29) - now out-of-range high??

03/06: LH 2.4 (1.5-9.3) - now low/mid in-range??
FSH: 4.0 (1.6-8.0)

Other pertinent facts:
-No, I've never done steroids/anabolics.
-My adrenals, though very slightly stressed, aren't in chaos.
-Thyroid looks good, too.
-I'll find out my most recent levels of LH/FSH/Total T next Monday Oct 6th.

WTF is the deal with the bottleneck at Androstenedione? Shit, I'd be happy for a ton of estrogen right now that I could just dial down with some Clomid.

Please provide any input and it is much appreciated.
My numbers are eerily similar to yours. My androstenedione was almost twice the upper limit. Your other results correlate to mine as well. This whole thing has really just confused me even further.

I'm still searching for a clear explanation on how "metabolites" can be in higher range but not T. Marianco's insight and this thread has actually been extremely helpful. I too, was viewing androstenedione as being "bottlenecked". But apparently this is wrong way of looking at it.

What are your symptoms? What initially led you to investigate hrt?
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