Dopamine Norepinephrine conversion

[cortguy]

I have a severe Dopamine deficiency where I get symptoms like Bradykinesia, Akinesia where
sometimes I can barely move all day. Weak voice, stiff muscles, mask face, no muscle strength,
sleep problems, memory, sex, motivation problems. My condition is from birth but too mild to
be considered a disease. I try Wellbutrin. It helps immensely the first 3 days. Then later on it
causes bad anxiety. I attribute this to Wellbutrin also increasing Norepinephrine. Is it possible
that the first few days I have a good amount of Dopamine but later on I have more NE than
Dopamine? Is there a way to slow down the DA to NE conversion? I think that might be the
problem. Is it true that ejaculation converts Dopamine to NE? Sex without ejaculation would
increase DA without increasing NE? How can I keep the balance of DA to NE favoring the
Dopamine? Or maybe take something that just increases Dopamine, like Selegiline. I also tried
Vitex+ Dl-Phenylalanine, it worked just like Wellbutrin. Maybe only take Vitex. (Works very
well to increase dopamine, it reduced my refractory period to nothing) I'm considering trying
Deprenyl, Levodopa, Imipramine, Moclobemide, Bromocriptine. Can I offset the anxiety
producing effect of Wellbutrin with 5-htp? I will not take an SSRI. I tried Zoloft once and it put
me in a coma. I could not move at all for a looooong time yet unable to sleep. Marianco or
anybody input please! Thanks.

[DAVID]

Originally Posted by cortguy

I have a severe Dopamine deficiency where I get symptoms like Bradykinesia, Akinesia where
sometimes I can barely move all day. Weak voice, stiff muscles, mask face, no muscle strength,
sleep problems, memory, sex, motivation problems. My condition is from birth but too mild to
be considered a disease. I try Wellbutrin. It helps immensely the first 3 days. Then later on it
causes bad anxiety. I attribute this to Wellbutrin also increasing Norepinephrine. Is it possible
that the first few days I have a good amount of Dopamine but later on I have more NE than
Dopamine? Is there a way to slow down the DA to NE conversion? I think that might be the
problem. Is it true that ejaculation converts Dopamine to NE? Sex without ejaculation would
increase DA without increasing NE? How can I keep the balance of DA to NE favoring the
Dopamine? Or maybe take something that just increases Dopamine, like Selegiline. I also tried
Vitex+ Dl-Phenylalanine, it worked just like Wellbutrin. Maybe only take Vitex. (Works very
well to increase dopamine, it reduced my refractory period to nothing) I'm considering trying
Deprenyl, Levodopa, Imipramine, Moclobemide, Bromocriptine. Can I offset the anxiety
producing effect of Wellbutrin with 5-htp? I will not take an SSRI. I tried Zoloft once and it put
me in a coma. I could not move at all for a looooong time yet unable to sleep. Marianco or
anybody input please! Thanks.

May be you can try dopamine agonist

[Naturdoc]

I don't know if you can or would want to slow down dopamine to NE conversion. I do know that increasing the conversion rate of NE to Epi can take a long time (months) as your body adjusts to higher NE levels. Have you looked at MAcuna for raising dopamine. The Chaste tree/Vitex was a good choice to try.

[MacDonnell]

You could always titrate the Wellbutrin with a SMALL dosage of Xanax (extended release), until your body gets used to the Wellbutrin. Eventually, the anxiety (caused by the Wellbutrin) should go away on its own. (Pardon me for sounding like my shrink!) :-)

[pmgamer18]

Originally Posted by MacDonnell

You could always titrate the Wellbutrin with a SMALL dosage of Xanax (extended release), until your body gets used to the Wellbutrin. Eventually, the anxiety (caused by the Wellbutrin) should go away on its own. (Pardon me for sounding like my shrink!) :-)

Yrs ago this is how my Dr. put me on Wellbutrin but in them days we did not know I had a pituitary problem. I don't do any of this stuff now.

[cortguy]

Thanks for the info guys. I tried Mucuna Pruriens and had a bad reaction to it. Chaste tree/Vitex is one of the best supplements I've taken. I tried TRT hoping it'll raise dopamine but I couldn't handle any amount of testosterone in any form. Occasional use of hydrocortisone is very good for me, it helps me sleep, although long term use makes me worse. Thyroid supplementation didn't help. I started Selegiline today. Hope it works.

[chip douglas]

Originally Posted by cortguy

Thanks for the info guys. I tried Mucuna Pruriens and had a bad reaction to it. Chaste tree/Vitex is one of the best supplements I've taken. I tried TRT hoping it'll raise dopamine but I couldn't handle any amount of testosterone in any form. Occasional use of hydrocortisone is very good for me, it helps me sleep, although long term use makes me worse. Thyroid supplementation didn't help. I started Selegiline today. Hope it works.

Be careful with Selegiline hydrochloride--If you're not prone to anxiety, it's probably not so bad, but I ended with panic attacks from 3 weeks on Selegiline Hydrochloride (Jumex), and that low on low dose.

[cortguy]

I am prone to anxiety. And you might be right. I took 2.5mg Selegiline 8 hours ago, now I have anxiety pretty bad. My hearing got ultra sensitive, heart palpitations and being easily startled. Something similar once happened when I tried thyroid meds. But I'll give Deprenyl some time. Maybe sides will go away. I want something to work.

[cortguy]

Selegiline I took shot up my blood pressure to 145/90! I've never had this high BP before. Never higher than 120/80. Is this dangerous? I just took 5mg Inderal (Beta Blocker) to lower it. I think it's working. Is this high BP on this drug common?

[pmgamer18]

Originally Posted by cortguy

Selegiline I took shot up my blood pressure to 145/90! I've never had this high BP before. Never higher than 120/80. Is this dangerous? I just took 5mg Inderal (Beta Blocker) to lower it. I think it's working. Is this high BP on this drug common?

Have you ever tested your cortisol levels sounds to me like your low.

[cortguy]

Here's my canary club saliva test results:
12PM(wake): 44 nM Elevated (13-24)
3:30: 13 nM Elevated (5-10)
8PM: 3 nM Normal (3-8)
12:30A: 6nM Elevated (1-4)

It's high, but successful antidepressant therapy could change all that. My second day on Selegiline (2.5mg) and I feel wonderful. And my libido is through the roof. My BP normalized, no anxiety, no palpitaions. I hope this drug works in the long term. Pmgamer in your opinion what kind of issues can I run into taking Selegiline in the long term?

[wildfox]

What about DL Phenylalanine (a precursor to L-tyrosine and PEA, and your body gets to decide which. Also, L-tyrosine is a precursor to dopamine and is available as a supplement as well. I'm glad you're feeling better on Selegiline. Inositol for anxiety.

....things to discuss with your doctor. You might throw out a post here to marianco (Dr. Marianco, that is). He's the neurotransmitter specialist.

[pmgamer18]

Originally Posted by cortguy

Here's my canary club saliva test results:
12PM(wake): 44 nM Elevated (13-24)
3:30: 13 nM Elevated (5-10)
8PM: 3 nM Normal (3-8)
12:30A: 6nM Elevated (1-4)

It's high, but successful antidepressant therapy could change all that. My second day on Selegiline (2.5mg) and I feel wonderful. And my libido is through the roof. My BP normalized, no anxiety, no palpitaions. I hope this drug works in the long term. Pmgamer in your opinion what kind of issues can I run into taking Selegiline in the long term?

Looks like your in stage 2 for Adrenal Fatigue.
http://www.chronicfatigue.org/DiagTech%201%262.html
http://www.chronicfatigue.org/ASI%202.html

[cortguy]

It does seem like stage 2 adrenal fatigue. So what do I do about it? How is it treated? Tried Phosphatidyl Serine. It was mildly effective, relaxed me a little bit. Is Hydrocortisone recommended for this stage?

[pmgamer18]

Originally Posted by cortguy

It does seem like stage 2 adrenal fatigue. So what do I do about it? How is it treated? Tried Phosphatidyl Serine. It was mildly effective, relaxed me a little bit. Is Hydrocortisone recommended for this stage?

My levels were low I am up on this but in your case go to this link and post to Val. she is dam good on this post your tests.
http://www.stopthethyroidmadness.com...4d2e0f2478e3f7

[DanielS3368]

This may be helpful :

Disulfiram has been found to inhibit the enzyme dopamine-beta-hydroxylase, blocking the metabolism of dopamine into norepinephrine. Combined with the dopamine agonist and/or reuptake effect of stimulants, this can cause a dramatic rise in synaptic dopamine levels, resulting in sleeplessness, paranoia, and, in extreme cases, stimulant psychosis.

Disulfiram - Wikipedia, the free encyclopedia

Anyone tried Disulfiram ?

[zkt]

" Is it true that ejaculation converts Dopamine to NE? Sex without ejaculation would
increase DA without increasing NE? "

Not sure if ejaculationn converts DA to Norepi but the PRL surge inhibits DA synthesis. Tanatric Buddists would practice sex without ejaculation for months at a time as have I in the past. It does tend to energise one.

[zkt]

Originally Posted by DanielS3368

This may be helpful :

Disulfiram has been found to inhibit the enzyme dopamine-beta-hydroxylase, blocking the metabolism of dopamine into norepinephrine. Combined with the dopamine agonist and/or reuptake effect of stimulants, this can cause a dramatic rise in synaptic dopamine levels, resulting in sleeplessness, paranoia, and, in extreme cases, stimulant psychosis.

Disulfiram - Wikipedia, the free encyclopedia

Anyone tried Disulfiram ?

Does Naltrexone have the same effect ?

Naltrexone - Wikipedia, the free encyclopedia

This bears looking into

[DanielS3368]

Originally Posted by zkt

" Is it true that ejaculation converts Dopamine to NE? Sex without ejaculation would
increase DA without increasing NE? "

Not sure if ejaculationn converts DA to Norepi but the PRL surge inhibits DA synthesis. Tanatric Buddists would practice sex without ejaculation for months at a time as have I in the past. It does tend to energise one.

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It seems too suggest below for POIS sufferers that there is an exccessive conversion of DA too NE+NOE and many other things..Although Iam not sure how accurate the articles below are but it be very good if Dr Marianco could have a look at it.

Only 5 years of POIS for me since age 19 plus Peyronies Disease since 15-16 young. Iam not able physically too have sex ever from the severe PD that I have and if I do ejaculate it causes POIS symptoms for days. Although not as bad as some people which can last 30 days.

It is amazing how all of my supposely prime years are really wasted away due to this POIS. I would pay all my money too cure this POIS and take out big loans if need be, dont care how much it cost and if I would have too spend the rest of my life financially poor , it would be very much worth it.

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Destruction of Excessive Orgasms
After you enjoyed too many sexual orgasms and/or too much pleasure, you have likely blown your brain/nervous bioelectric circuit breaker, and may have started to deal with the Sexual Exhaustion Symptoms - the exhaustion of the hypothalamus-pituitary-adrenal/-testicular axis, very possibly or likely including the hypothalamus-pituitary-thyroid dysfunction, and deducing/downgrading or desensitization of the androgen hormonal receptors in the hypothalamus, hippocampus and pituitary, resulting from the Nervous Excitotoxicity and Inflammation induced by excessive norepinephrine, epinephrine and glutamate (& other excitory neurohormones, for a short-term pleasure reward and the long-term dopamine depletion), long-term excessive elevation of prolactin ( to inhibit GnRH release from the hypothalamus and therefore LH and FSH secretion from the pituitary and to directly desensitize pituitary gonadotropic cells and the Leydig cells of the testes) , and Prostaglandin E2 (the brain heater for the core temperature rise!) At the sexual exhaustion state, the constant elevation of excessive prolactin (mimics Hyperprolactinaemia) suppress sensitivity of prolactin-negative feedback on hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons for persistently low dopamine synthesis, blocks the beta-adrenergic receptors and nitric oxide nervous mechanisms and promotes norepinphrine and epinpehrine binding to the alpha-adrenergic receptors for vasoconstriction and restriction of blood flow to the brain and genitals, and destroys or desensitizes the hypothalamic androgen receptors, as described in
Mechanisms underlying {beta}2-adrenoceptor-mediated nitric oxide generation by human umbilical vein endothelial cells -- Queen et al. 576 (2): 585 -- The Journal of Physiology Online
16-kDa Prolactin Down-Regulates Inducible Nitric Oxide Synthase Expression through Inhibition of the Signal Transducer and Activator of Transcription 1/IFN Regulatory Factor-1 Pathway -- Lee et al. 65 (17): 7984 -- Cancer Research
16K-Prolactin Inhibits Activation of Endothelial Nitric Oxide Synthase, Intracellular Calcium Mobilization, and Endothelium-Dependent Vasorelaxation -- Gonzalez et al. 145 (12): 5714 -- Endocrinology
Prolactin Induces Regional Vasoconstriction through the {beta}2-Adrenergic and Nitric Oxide Mechanisms -- Molinari et al. 148 (8): 4080 -- Endocrinology
Wiley InterScience :: Session Cookies
http://www.psy.fsu.edu/faculty/hull/D&H_review.pdf
The role of nitric oxide in the peripheral vasoconstriction caused by human placental lactogen in anaesthetized pigs -- Molinari et al. 91 (3): 603 -- Experimental Physiology
The effect of dehydroepiandrosterone on regional blood flow in prepubertal anaesthetized pigs -- Molinari et al. 557 (1): 307 -- The Journal of Physiology Online
Mechanisms Underlying the Diminished Sensitivity to Prolactin Negative Feedback during Lactation: Reduced STAT5 Signaling and Up-Regulation of Cytokine-Inducible SH2 Domain-Containing Protein (CIS) Expression in Tuberoinfundibular Dopaminergic Neuron
Cutting down the brain and genital blood circulation naturally alternates the neurotransmitters and hormonal syntheses, the major brain nervous function including the dopamine, acetylcholine, serotonin, GABA, noradrenergic, adrenergic, glutamate, oxytocin, nitric-oxide(NO), vagal and autonomic nerves functions, and the hypothalamus-pituitary-adrenal and -testicular(-ovarian) function.
The Traditional Chinese Medicine has termed the hypothalamus-pituitary-adrenal (HPA) exhaustion as "Kidney Deficiency", since the classic Chinese anatomy text assumed the tiny adrenal gland, sitting on the top of the kidney, is a part of the kidney about 2000 years ago. The HPA exhaustion results in the erratic release of CRH (corticotropin releasing hormone), POMC (proopinomelanocortin), ACTH (adrenocorticotropc hormone), ß-lipotropic hormone, ß-endorphin, α-melanocyte-stimulating hormone (α-MSH), ß-MSH, CA (catecholamines) and TSH (thyroid stimulation hormone), in response to stress, sex and environmental/dyshomeostatic stimuli. Since skin and hair follicles also display a functional equivalent of the HPA axis, sexual exhaustion will also extensively affect your skin (for examples: darkening skins in certain areas such as eye cycles, nips, labia minors, foreskin, perineum and groins, due to excessive release or trapping of the POMC peptide α-MSH which is also an anti-inflammatory and immunomodulating hormone - anti-tissue abrasion!) and the hair (for examples: hair loss in the scalp and gray hair, but it won't grow hair in your palms although it will destroy your HPA axis.) The explanation of the HPA, skin and hair connection are given in the following links: Neuroendocrinology of the Skin -- Slominski and Wortsman 21 (5): 457 -- Endocrine Reviews, http://www.pubmedcentral.nih.gov/pic...6&blobtype=pdf , http://www.fasebj.org/cgi/reprint/04-1968fjev1.pdf, http://www.tufts.edu/sackler/pharmac...brain-skin.pdf , Corticotropin Releasing Hormone and Proopiomelanocortin Involvement in the Cutaneous Response to Stress -- Slominski et al. 80 (3): 979 -- Physiological Reviews , {alpha}-MSH related peptides: a new class of anti-inflammatory and immunomodulating drugs -- Luger and Brzoska 66 (3): iii52 -- Annals of the Rheumatic Diseases , Alterations in hypothalamic-pituitary-adrenal axis...[Brain Res. 2003] - PubMed Result , http://www.fasebj.org/cgi/reprint/19/10/1332.pdf, The Skin POMC System (SPS): Leads and Lessons from the Hair Follicle -- PAUS et al. 885 (1): 350 -- Annals of the New York Academy of Sciences , and JCI - A nervous breakdown in the skin: stress and the epidermal barrier
As a result, sex is like a good investment with a bad return. When you reach the neuro-endocrine breaking point, it is like the stoke market cash leading to the great depression!! Yes, excessive sex induces psychological and physiological disorders.