E2 lab results

[Prospero]

My old labs 01/2007 before arimidex (and no TRT or anything)::
E1 300nmol/l (<370)
E2 150pmol/l (40-160)

I've been taking arimidex since then and now tested again 05/2007 and the results are (with stable 0.25mg ed for about three months):
E1 191nmol/l (<370)
E2 100pmol/l (40-160)

Interestingly, even with 0.25mg ED the lowering of the values has not been too dramatic. After starting the arimidex at 0.25mg e2d I felt no difference at all, so after a few weeks I increased to 0.25mg ed. After this, I felt my libido come back for a couple of weeks, but after that it has been gone again. Still, I really feel better.

Significant change has been that I've started getting results at gym - beforehand I'd gone to gym for years with practically no progress. My bench increased more in two months than in the last two years!! My testosterone and free testosterone have always been at middle of reference range, so lack of testosterone can't explain the poor gym results. Interesting!

The values are not that low yet so I'm increasing the arimidex dosage to 0.50mg ed and see what happens. I'd really like to get my libido back! It felt so heavenly for those two weeks to actually lust women and have spontaneous erections from dirty thoughs.

[pmgamer18]

If you got your libido back and then it went away this means your E2 is going to low stop the arimidex until your libido or morning wood comes back then go back on it but do less. I use my wood as a gauge to not go to low. Going to low is just as bad as to high.

Originally Posted by Prospero

My old labs 01/2007 before arimidex (and no TRT or anything)::
E1 300nmol/l (<370)
E2 150pmol/l (40-160)

I've been taking arimidex since then and now tested again 05/2007 and the results are (with stable 0.25mg ed for about three months):
E1 191nmol/l (<370)
E2 100pmol/l (40-160)

Interestingly, even with 0.25mg ED the lowering of the values has not been too dramatic. After starting the arimidex at 0.25mg e2d I felt no difference at all, so after a few weeks I increased to 0.25mg ed. After this, I felt my libido come back for a couple of weeks, but after that it has been gone again. Still, I really feel better.

Significant change has been that I've started getting results at gym - beforehand I'd gone to gym for years with practically no progress. My bench increased more in two months than in the last two years!! My testosterone and free testosterone have always been at middle of reference range, so lack of testosterone can't explain the poor gym results. Interesting!

The values are not that low yet so I'm increasing the arimidex dosage to 0.50mg ed and see what happens. I'd really like to get my libido back! It felt so heavenly for those two weeks to actually lust women and have spontaneous erections from dirty thoughs.

[Prospero]

Originally Posted by pmgamer18

If you got your libido back and then it went away this means your E2 is going to low stop the arimidex until your libido or morning wood comes back then go back on it but do less. I use my wood as a gauge to not go to low. Going to low is just as bad as to high.

I'm afraid it doesn't work that easily for me. I did try that already, and just stopping arimidex didn't help bring back libido. I did take into consideration the half-life of arimidex and waited definitely long enough. If I stop arimidex, I just start feeling worse in a few days. I tried stopping arimidex twice, so I'd consider that definite.

I have, indeed, read the numerous messages here about arimidex and how people can find the optimal dose by increasing dose until E2 goes too low, and then decrease dose until E2 goes too high etc.. Doesn't work for me, unfortunately. It was like something in my body adapted to the lowered E2 in two weeks and "fixed" the change, which caused my libido to return..

It seems my change of E2 is quite modest for 0.25mg ed.. For some, it seems 0.25mg e3d works in lowering e2 much more. The dose 0.25mg ed did only lower my E2 to about half of the original value. Still at about middle of reference range, and I presume too high.

My SHBG has been 30nmol/l (13-62).

[pmgamer18]

You are not all the high 150 pmol/l = 43pg/ml in my units and I try to keep my e2 at 20 pg/ml and I am on TRT. You need to be care full are you doing Arimidex at that does and retesting or going by how you feel to tell if your still to high. I feel some one not on TRT taking .25mgs everyday will fall to low and the longer your to low the longer it takes to get levels back up. Your not on TRT so you don't have anything to dirve it back up it can take you months to get your levels back up. Best thing you can do it test it. I went to low when I first started and I am on TRT it took me 6 weeks to get back up.

[Prospero]

Originally Posted by Prospero

My old labs 01/2007 before arimidex (and no TRT or anything)::
E1 300nmol/l (<370)
E2 150pmol/l (40-160)

I've been taking arimidex since then and now tested again 05/2007 and the results are (with stable 0.25mg ed for about three months):
E1 191nmol/l (<370)
E2 100pmol/l (40-160)

Unit conversion (divide by 3.671 for pmol/l -> pg/ml):
Original E2: 40.9 pg/ml (10.9 - 43.6)
New E2: 27.2 pg/ml (10.9 - 43.6)

It would be interesting to stop arimidex and see from labs how fast E2 rises, but I think I'll try to get E2 first lower and see if my libido gets better. At 27.2 pg/ml I'm still at 50% of the reference range! Much better than at 92% of ref.range I was originally, but not particularly low either. Or is it, really?

Originally Posted by PMGAMER18

I feel some one not on TRT taking .25mgs everyday will fall to low and the longer your to low the longer it takes to get levels back up. Your not on TRT so you don't have anything to dirve it back up it can take you months to get your levels back up. Best thing you can do it test it. I went to low when I first started and I am on TRT it took me 6 weeks to get back up.

I'm surprised you wrote about long time required to make more E2.

I've understood E2 half-life is rather short (less than day) and thus lots of E2 is produced all the time via aromatization to counter the loss from circulation. Arimidex would take around two weeks to totally disappear (half-life 2-3 days), so after two weeks I'd expect arimidex effect to be totally gone and E2 level to be back where I started (or higher). I may be totally wrong, this was just my assumption based on the half-lifes.

From FDA documentation on Arimidex:
"The recommended daily dose, ARIMIDEX 1 mg, reduced estradiol by approximately 70% within 24 hours and by approximately 80% after 14 days of daily dosing. Suppression of serum estradiol was maintained for up to 6 days after cessation of daily dosing with ARIMIDEX 1 mg."

I'm indeed getting myself tested for E1 and E2 to see how they change based on arimidex dose. I now have baseline and .25mg ed levels (stabilized, I presume, in a couple of months). Of course, final judgment is how I feel, and testing serves to check that I don't go too low. After changing dose and waiting a couple of months to stabilize, I'll get myself tested again.

Thanks for your comments!

[cwoody123]

My estrodial was 124 pmol/l a few weeks ago. I feel that since finishing Clomid my nipples have become really flabby. Do you think this is due to my estrodial being slightly elevated or something else?

I have some Arimidex and i am going to see how my body reacts to taking this. Just wondering if you have any negative effects from elevated estrodial?

Have you thought about taking one of the stronger anti-estrogens?

[pmgamer18]

Prospero your not on TRT right do you do SOY any kind I can't see how your E2 is going so high. I was on 200mgs every 2 weeks of Depo T shots and I did .5 mgs of Arimidex everyday to get my E2 down from the 90's pg/ml. I come down after 6 weeks to 24 my libido was better but the best thing was no more ED and I could have sex with my wife with out using a penis pump and cock ring this had to do this for 10 dam yrs and I could not reach an orgasm.

After getting down to 24 we lowed the dose to .5 every other day and in 4 weeks my levels came back below 8 the lab only went down to 8 pg/ml. I stoped the arimidex because I had ED again and taking a pill did not work. It took me 6 week off Arimidex to get my levels back up and the first thing that happened was I got morning wood back my test was 20 pg/ml.

I have never met anyone with E2 as bad as I have it. Your not on TRT and your levels are still high for me 27 what is your SHBG is it's on the low side like mine you can go down to 15 pg/ml my SHBG is 22.

Do .5 mgs every other day and see if this helps and if your doing any kind of SOY stop.

[Prospero]

Originally Posted by pmgamer18

Prospero your not on TRT right do you do SOY any kind I can't see how your E2 is going so high.

No, I don't use soy of any kind.

Indeed, it is a mystery to me why my E2 is so high. Either something is producing too much E2 and E1 (weird as my testosterone and androstenedione levels are ok) or there is something wrong with the removal of E2 from circulation in my body - liver or other part of enterohepatic cycle. The latter is what I'm researching now, and what to measure with labs. My standard liver labs like ALAT have always been ok.

One logical possilibity is that if there is something wrong with my enterohepatic cycle, then perhaps arimidex pharmacokinetics is different too, and I don't get the same concentrations to blood from 0.25mg ED as a healthy person would. Impropable, but a possibility.

[Bayou230]

I’m not a big fan of using libido or wood as a benchmark for assessing E2 levels, Mine have been all over the chart...from above reference range to well below. Now that I’m solidly in the middle, I feel no different than at the high or low points, with the exception of noticing a decreased tendency to retain water.

I’d be interested how this works out for you. Good luck!

Regards,
B230

[mickyblues]

This is interesting, I to have a samiliar problem with E2. I have been taking aromasin though. This is my 3rd run at it since the beginning of the year to keep my estro low and hopefully completely down after cessation. I also tried AIFM which seem to work pretty well, however, after stopping I seem to retain more water again. Not sure if this has to do with to much abdominal fat.

[plymouth city]

Originally Posted by Prospero

No, I don't use soy of any kind.

Indeed, it is a mystery to me why my E2 is so high. Either something is producing too much E2 and E1 (weird as my testosterone and androstenedione levels are ok) or there is something wrong with the removal of E2 from circulation in my body - liver or other part of enterohepatic cycle. The latter is what I'm researching now, and what to measure with labs. My standard liver labs like ALAT have always been ok.

One logical possilibity is that if there is something wrong with my enterohepatic cycle, then perhaps arimidex pharmacokinetics is different too, and I don't get the same concentrations to blood from 0.25mg ED as a healthy person would. Impropable, but a possibility.

Your E levels are fine now
E1 191nmol/l (<370)
E2 100pmol/l (40-160)

What is your DHEA levels? That will aromotize into E as well.

I had issues with normal T and high E as well.
11 - 06 BW
TT - 490
FT - 18.9
E2 - 43
DHEA - 520

Mine was a tripple wammy - DHEA high(good thing, but will jack up E), alcohol use(again, raises E2) and shitty diet. Once I got on a solid diet, started taking the right supplements, and quit drinking, felt better

New BW
TT - 731
FT - 23.9

Don't know my E2 level yet, I will get that checked soon here as I am embarking on a new E management routine.

[Prospero]

Originally Posted by plymouth city

Your E levels are fine now
E1 191nmol/l (<370)
E2 100pmol/l (40-160)

What is your DHEA levels? That will aromotize into E as well.

As far as I understand, DHEA is converted to androstenedione first.. Aromatization happens from testosterone (to E2) or androstenedione (to E1). Other possibilities are androstenedione->testosterone and testosterone->DHT. I think that is the basic hormone synthesis in testicles and adrenal cortex.

Anyway, my labs:
Androstenedione 6.9 nmol/l (2.1 - 10.5)
Progesterone 2.2 pmol/l (0.3 - 3.2)
DHEA 22 nmol/l (7-45)
DHEAS 6.9 umol/l (2.8 - 13.6)
Aldosterone 263 pmol/l (30-450)
Renin 6 pmol/l (10-30)

There were taken at the same time (same blood) as the first E1,E2 labs before starting arimidex.
I have been unable to interpret the low renin - renin was taken just in case aldosterone is not ok, to interpret adrosterone result.

Originally Posted by plymouth city

Mine was a tripple wammy - DHEA high(good thing, but will jack up E), alcohol use(again, raises E2) and shitty diet. Once I got on a solid diet, started taking the right supplements, and quit drinking, felt better

New BW
TT - 731
FT - 23.9

Don't know my E2 level yet, I will get that checked soon here as I am embarking on a new E management routine.

What were your symptoms?