How long does a first injection take to work?

[Mrmanguy84]

How long does it take for a first injection to work? What is the longest reasonable time?

My doctor wanted to give me a shot to confirm that my T is low (I've tested anywhere
from 330 to 460 with normal lab ranges of 400-1080). He said if my
testosterone was truly low, I'd notice a difference within a day or
two of getting the shot. It's been almost 48 hours now and I don't
feel anything yet. The does was 200 mg/ml to the butt. I'm 23 and 170 lbs.

How long does it really take? I'm nervous that nothing will happen. I
see the doctor again on Wednesday.

I forgot to add - my symptoms are low libido, fatigue, headaches, low
appetite and erectile dysfunction. I'm especially interested in the
libido and erectile part because it's the most obvious. Whatever it is seems to be getting worse over time.

I'd also like to ask about a weird rush I got when the nurse gave me the shot. I wasn't expecting to feel anything but I had this thing rush to my head. Maybe I was just nervous from having a needle squirting into me so long, or the awkwardness of standing there with my pants halfway down like that. I'm not really concerned about it but I was wondering if anyone else has ever had that. The nurse said she'd never seen it before. I've certainly never felt anything quite like it before.

--John

[JanSz]

Originally Posted by Mrmanguy84

How long does it take for a first injection to work? What is the longest reasonable time?

My doctor wanted to give me a shot to confirm that my T is low (I've tested anywhere
from 330 to 460 with normal lab ranges of 400-1080). He said if my
testosterone was truly low, I'd notice a difference within a day or
two of getting the shot. It's been almost 48 hours now and I don't
feel anything yet. The does was 200 mg/ml to the butt. I'm 23 and 170 lbs.

How long does it really take? I'm nervous that nothing will happen. I
see the doctor again on Wednesday.

I forgot to add - my symptoms are low libido, fatigue, headaches, low
appetite and erectile dysfunction. I'm especially interested in the
libido and erectile part because it's the most obvious. Whatever it is seems to be getting worse over time.

I'd also like to ask about a weird rush I got when the nurse gave me the shot. I wasn't expecting to feel anything but I had this thing rush to my head. Maybe I was just nervous from having a needle squirting into me so long, or the awkwardness of standing there with my pants halfway down like that. I'm not really concerned about it but I was wondering if anyone else has ever had that. The nurse said she'd never seen it before. I've certainly never felt anything quite like it before.

--John

You are very young, god chance is that you are secondary,
HCG alone may work better for you, much more natural.

HCG preserves fertiliy
testosterone will sterilize you

Read my post to livelylady's husband.
http://forum.mesomorphosis.com/586971-post4.html
.

[zkt]

I believe your reaction was psychological. You might have a sore butt for a few days. Thats a common reaction to initial shots. At first my leg was so sore I could barely walk.
You mentioned only the concentration of the shot. But how many ml was in the srynge ? I centainly agree with the doc in that you should feel horney in a day of two- when blood levels reach their maximum concentration. Not so sure I agree with his reasoning that this will prove that youre low. If you had normal levels of say, 600, and shot it up to 1200 you would more than likely, also feel horney as hell.
Jan is right, T will shrink your balls unless used in conjunction with hcg if your problem is secondary. On the other hand, the continued use of hch will supress your pituitary production of LH.
GL

[JanSz]

Originally Posted by zkt

I believe your reaction was psychological. You might have a sore butt for a few days. Thats a common reaction to initial shots. At first my leg was so sore I could barely walk.
You mentioned only the concentration of the shot. But how many ml was in the srynge ? I centainly agree with the doc in that you should feel horney in a day of two- when blood levels reach their maximum concentration. Not so sure I agree with his reasoning that this will prove that youre low. If you had normal levels of say, 600, and shot it up to 1200 you would more than likely, also feel horney as hell.
Jan is right, T will shrink your balls unless used in conjunction with hcg if your problem is secondary. On the other hand, the continued use of hch will supress your pituitary production of LH.GL

If he is seondary, that means
balls are ok
but
not enough LH

so secondaries have already diminished LH production.
Further suppressing it does not mater (or is lesser harm).

Similarly if he uses testosterone he supresses his testicles.

Have to make choice.

Using hcg only would make him more natural, would preserwe more of his body control.

He should still have normal 24 hr testosterone leels (very important), and fertility.
When on T shots, natural 24 hr testosterone level cycling and fertilty is gone.
.
.

[zkt]

I meant primary. Pm me your needle supplier ?

[JanSz]

Originally Posted by zkt

I meant primary. Pm me your needle supplier ?

I can use a reliable supplier, pls send info.

[chap]

blood levels from a shot of testosterone cypionate peak within two days of the injection and then gradually fall from there

[cpeil2]

Originally Posted by Mrmanguy84

He said if my
testosterone was truly low, I'd notice a difference within a day or
two of getting the shot. It's been almost 48 hours now and I don't
feel anything yet. The does was 200 mg/ml to the butt. I'm 23 and 170 lbs.

That is simply incorrect. The response to a single injection of testosterone is extremely variable. Some guys don't notice a thing, others do.


It is a common practice, when initiating TRT with injections, to give an initial loading dose. Even after a loading dose, a lot of guys, expecting that they are going to feel great right away, complain that they felt no effect from the initial shot.

[zkt]

Originally Posted by cpeil2

That is simply incorrect. The response to a single injection of testosterone is extremely variable. Some guys don't notice a thing, others do.


It is a common practice, when initiating TRT with injections, to give an initial loading dose. Even after a loading dose, a lot of guys, expecting that they are going to feel great right away, complain that they felt no effect from the initial shot.

thats because there are other factors involved in determining libido. but given that all of them are ok- t will increase libido.

[Mrmanguy84]

The dose was 1 ml of the 200mg/m. I didn't notice that part.

JanSz- I have no intention of staying on the shots long-term. My doctor only wanted to do this to make sure that low T really was my problem before exploring other avenues of fixing it. He said it would be a one-time thing only and that this wouldn't mess up my pituitary axis or shut down my balls.

I don't know that I'm secondary (if T really is the problem, that is). My FSH has always been near the top of the range. A couple times my LH has looked rather low (as low as 2.8 on a normal range of 2-12) but once it registered at like a 5.6 or so, and I understand it's quite a variable thing depending on when they catch you.

But even if I was, and took Hcg, the benefits would be derived from higher testosterone, and apparently just putting T into me isn't doing anything...

The plan was that if this shot established that I felt better with higher T then we'd operate to take care of my varicocele in the hopes that my body will improve on its own (I've read a couple studies now which suggest this should work). Pmgamer told me Megazoid is the local expert on that which is what lead me to this board. I haven't heard back from him via PM yet, though.

zkt - What are the other factors that can mess up a libido?

cpeil2- You mention a 'loading dose' and that a lot of guys don't feel anything after the first dose. Do they feel something on later doses? Would that mean I would on a second shot? The prescription I filled included another dose so maybe that's what the doctor has in mind.

I'm trying to understand why my symptoms, which correlate so well to a confirmed low T, would not improve with supplementation. Any ideas? Maybe if my body was converting too much to estrogen - would that block the shot from being helpful? I don't have enlarged breasts - is estrogen dominance still a possibility?

We tested my estradiol once, but I am not sure the test was valid as the results looked odd. Should I ask for another one? The results said this:

Estradi <25pg/ml (<78)
INTEPRETATION OF ESTRADIOL TESTING (pg/ml) :\XODOA\ Adult Male...... <=77\XODOA\Adult Female:\XODOA\ Follicular....... 39-189 \XODOA\ Mid-Cycle Peak..... 94-508\XODOA\ Luteal Phase..... 48-309 \XODOA\ Postmenopausal... <=41\XODOA\

"The following non-numeric lab results were dispersed to the flowsheet even though numeric results were expected: Estradi, <25"


I really appreciate any and all help. This all just makes no sense to me. I'm very frightened. I miss feeling like myself!

--John

[zkt]

How bout depression ? It is associated with low libido, self-esteem, joy in being alive.
The wrong sexual situation with the wrong person. Or no partner at all.
Worry. Just off the top of my head.
And, of course, biochemical problems, althou the above may well boil down to biochemistry. Low thyroid or adrenal output, messed up levels of dopamine or seratonin. Many more here too.
I would think that 200mg would override a lot of problems, altho the outcome might be increased aggressive feelings rather than increased libido. T is quite certainly involved in aggression as it is in libido.
Still dont think that manifestation of either is evidence of low T.

[cpeil2]

Originally Posted by zkt

thats because there are other factors involved in determining libido. but given that all of them are ok- t will increase libido.

Agreed, but that's a big "if" - and a further reason why thinking that somebody's response or lack thereof to a single loading dose of T is determinative is just plain wrong.

[zkt]

Only part of the time. No reaction implies nothing. But a positive reaction is an indication of a deficiency in the face of supportive labs. But I totally agree- its a hell of a poor way to diagnose the problem because the doc will probably assume that no reaction means no problem.

[cpeil2]

Originally Posted by zkt

Only part of the time. No reaction implies nothing. But a positive reaction is an indication of a deficiency in the face of supportive labs. But I totally agree- its a hell of a poor way to diagnose the problem because the doc will probably assume that no reaction means no problem.

Right, my assertion was overbroad.

[cpeil2]

Originally Posted by Mrmanguy84

cpeil2- You mention a 'loading dose' and that a lot of guys don't feel anything after the first dose. Do they feel something on later doses? Would that mean I would on a second shot? The prescription I filled included another dose so maybe that's what the doctor has in mind.

It's hard to make a prediction. When I started on shots, my first shot was a loading dose of 200 mg. I had a noticeable, early response to injections - I began to feel an effect within hours after the first shot.

Others don't feel a thing after the first shot, and don't feel much of anything for weeks and sometimes even months after starting shots.

That's why it is so silly for your doc to think that a lack of subjective response to a single dose of T is a determinative indication that your T is not too low.