Hydrocortisone dosing

[zkt]

Those of you on low doses of HC(5mg or so),what time of day do you take it? Seems like it would matter because of the half life nad circadian rythm of cortisol production . 8-12 hrs is the half life. Any thoughts on low dosage scheduling with Medrol whose half life is much shorten 2.5-3.5 hrs. It would be very unfortunate if low doses of Medrol werent doable due to its short half life. Need more research. Anyone know ?

[pmgamer18]

I think you have this wrong HC has a life of about 3 to 4 hrs. Medrol is up to 18 hrs. I guess you did not read where I posted this.
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1mg of Medrol is = to 5mgs of HC. here is a cut and paste from a FAQ's that Bob did at STTM.
from this link.
Stop The Thyroid Madness » ADRENALS FAQ–the most frequently asked questions

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46) The HC doesn’t seem to last long enough - what is Medrol? Dr Peatfield says that HC is “not stored by the body and gets rapidly used; 2 or 3 hours will see it pretty well used up completely.” Some people metabolize HC faster than others. If a person has symptoms of low cortisol despite gradually working up to about 30mg of HC, they may want to talk with their doctor about trying Medrol. Depending on the persons metabolism, the 1/2 life of Medrol can range from 18 to 36 hours.

47) How do I dose Medrol? Conversion tables will tell you that 1mg of Medrol = 5mg of HC. Persons who are already on HC can gradually switch over to Medrol, and typically end up with about 6mg of Medrol spread out through the day. It does not need to be taken every 4 hours like you would with HC, but a typical dosing schedule might be 3 mg at wake, 2mg in the afternoon, and 1mg at bedtime. Further discussion about Medrol can be seen here Stop The Thyroid Madness :: View topic - More info on Medrol
and here Stop The Thyroid Madness :: View topic - Medrol - Dosing & Timing

[The_Skeptic]

Medrol has a much longer half life than hydrocortisone, which lasts about four hours.

[zkt]

I reversed the numbers.