Importance of estrone (E1)?

[hippii]

Hi,

I'm wondering whether E1 levels have influence on my hypogonadal symptoms (low libido etc.). I guess I may be a primary hypogonadal, since my blood results before treatments were:

Total T 22 nmol/l (range 10-38)
SHBG 70 nmol/L (13-71)
free T 220 pmol/l (150-500)
estradiol 90 pmol/l (<160)
prolactin 289 (70-300)
TSH 1.8 (0.3-4.5)
fT4 17 (10-21)
LH 11
FSH 20
iron, ferritin etc. okay

At the moment I'm on trial of sustanon shots, and soon going to lab tests to see how my T and fT have improved and whether they have something to do with my symptoms.

I was wondering since my E2 is okay (well, my fT is low due to high SHBG so there is not much to convert to E2), can E1 still be high, and causing the symptoms? is E1 as potent as E2? I have not seen many hypogonadal diagnosis articles which say that measurement of E1 is important.. they all are talking about E2.

Thanks for your answers and help

[JanSz]

Originally Posted by hippii

Hi,

I'm wondering whether E1 levels have influence on my hypogonadal symptoms (low libido etc.). I guess I may be a primary hypogonadal, since my blood results before treatments were:

Total T 22 nmol/l (range 10-38)
SHBG 70 nmol/L (13-71)
free T 220 pmol/l (150-500)
estradiol 90 pmol/l (<160)
prolactin 289 (70-300)
TSH 1.8 (0.3-4.5)
fT4 17 (10-21)
LH 11
FSH 20
iron, ferritin etc. okay

At the moment I'm on trial of sustanon shots, and soon going to lab tests to see how my T and fT have improved and whether they have something to do with my symptoms.

I was wondering since my E2 is okay (well, my fT is low due to high SHBG so there is not much to convert to E2), can E1 still be high, and causing the symptoms? is E1 as potent as E2? I have not seen many hypogonadal diagnosis articles which say that measurement of E1 is important.. they all are talking about E2.

Thanks for your answers and help

SHBG 70 nmol/L

is no joke, indicate some metabolic disrurbance elsewere..

I suggest NutrEval test
from Genaova Diagnostics.

Also good general blood test at Quest Diagnostics.
My list is on post #44
Jan's BloodTest April13/2007 - Page 2

[hippii]

Originally Posted by JanSz

SHBG 70 nmol/L

is no joke, indicate some metabolic disrurbance elsewere..

I suggest NutrEval test
from Genaova Diagnostics.

Also good general blood test at Quest Diagnostics.
My list is on post #44
Jan's BloodTest April13/2007 - Page 2

Thanks JanSz for your reply. Yeah, it's a mystery for me why my SHBG is so elevated. My TSH and T3 will be tested also in the next lab test. My prolactin is on the upper range, but actually prolactin is a SHBG-lowering protein.. on the other hand, high prolactin has been known for the libido-lowering effects.

so I'm wondering the E1-SHBG connection, if there is one. Regarding those hormone panels, I guess those are not available in Scandinavia, so I would like to discuss the needed tests with my doctor. Nevertheless, the sustanon shots are not working like I was hoping, so I'm hoping that I will get a trial of Dostinex.

But as the title was regarding the importance of E1, has anyone comment on that?

[JanSz]

Originally Posted by hippii

Thanks JanSz for your reply. Yeah, it's a mystery for me why my SHBG is so elevated. My TSH and T3 will be tested also in the next lab test. My prolactin is on the upper range, but actually prolactin is a SHBG-lowering protein.. on the other hand, high prolactin has been known for the libido-lowering effects.

so I'm wondering the E1-SHBG connection, if there is one. Regarding those hormone panels, I guess those are not available in Scandinavia, so I would like to discuss the needed tests with my doctor. Nevertheless, the sustanon shots are not working like I was hoping, so I'm hoping that I will get a trial of Dostinex.

But as the title was regarding the importance of E1, has anyone comment on that?

I do not know where you are located, but Genova is international, have a presence in

Finland
Norway
Sweden

check the map:

Genova Diagnostics - International Overview

[thenxtgrt1]

Originally Posted by hippii

Thanks JanSz for your reply. Yeah, it's a mystery for me why my SHBG is so elevated. My TSH and T3 will be tested also in the next lab test. My prolactin is on the upper range, but actually prolactin is a SHBG-lowering protein.. on the other hand, high prolactin has been known for the libido-lowering effects.

so I'm wondering the E1-SHBG connection, if there is one. Regarding those hormone panels, I guess those are not available in Scandinavia, so I would like to discuss the needed tests with my doctor. Nevertheless, the sustanon shots are not working like I was hoping, so I'm hoping that I will get a trial of Dostinex.

But as the title was regarding the importance of E1, has anyone comment on that?

hippii...I just had labwork completed and estrone came back above the range. Test was urine analysis. The majority of what I've read seems to indicate that the pathway between E1 and E2 work both ways. Thus if E1 is high, E2 will be as well.

I work quite a bit. But any good info I find will be posted.

[Fraggle]

How old are you? SHBG and age are directly correlated.

E2(estradiol) has much greater activity at the receptor then E1(estrone). Generally, if E2 is high, then E1 will be similarly high.

The clinical method for approaching this would be to reduce aromatase activity and shift in favor of 5-alpha reductase. This would occur if you switch from IM injections to androgel or testim.

You can also use an aromatase inhibitor. If you don't want to use a pharmaceutical AI, you can try anything with large quantities of resveratrol -- the compound found naturally in red wine. This should reduce your conversion to E2 and can potentially reduce SHBG.

Ultimately, high E2 is going to decrease libido and have an impact on erectile function. If E2 moves to far in the other direction, then cardiovascular health, bone mineral density and libido will all be effected.

[thenxtgrt1]

Originally Posted by Fraggle

How old are you? SHBG and age are directly correlated.

E2(estradiol) has much greater activity at the receptor then E1(estrone). Generally, if E2 is high, then E1 will be similarly high.

The clinical method for approaching this would be to reduce aromatase activity and shift in favor of 5-alpha reductase. This would occur if you switch from IM injections to androgel or testim.

You can also use an aromatase inhibitor. If you don't want to use a pharmaceutical AI, you can try anything with large quantities of resveratrol -- the compound found naturally in red wine. This should reduce your conversion to E2 and can potentially reduce SHBG.

Ultimately, high E2 is going to decrease libido and have an impact on erectile function. If E2 moves to far in the other direction, then cardiovascular health, bone mineral density and libido will all be effected.

Fraggle...I'm only early 30s. Test did not include SHBG. But total estrogens were way too high. The range is 4-22. Mine was at 27

Although this is not the case with me, Is it possible to have high E1 and low E2? Doc has me on arimidex. Not on anything else at the moment. Do you have any experience with Arimidex or any other anti-estrogens?

Not really sure why this is happening. Never used AAS. BTW, this test was done after a month of HCG at only 200 iu / EOD. The way I "felt" when I took the test is how I usually feel. I believe estrogen has been a problem for awhile now.

I've been researching resveratrol and definitely will be trying it soon.