Non responder to TRT

[jaydee]

If you are a non responder to TRT, will the health risks of having low T still apply to you? Or is it that if you show on blood tests or urines that your T is at the appropriate level, the testosterone must be doing its job. What if there is a receptor problem or somthing?

Surely for the depression that comes with having no libido and ED, there must be a way mother nature balances this out so you dont have to live depressed for the next 50 odd years of your life. Im talking more about young guys who are in their 20's. It sounds morbid but I hope im not around for another 50 years in the state I am in. This post is a little bit of a vent I guess. I took finasteride and am so far totally refractory to any treatment. Total ED, Peyronnies Disease, shrinkage, zero libido.....baah!!!..... Relationships are crumbling around me and im over it. Screw putting up with this for the next 40 years.

[JanSz]

Originally Posted by jaydee

If you are a non responder to TRT, will the health risks of having low T still apply to you? Or is it that if you show on blood tests or urines that your T is at the appropriate level, the testosterone must be doing its job. What if there is a receptor problem or somthing?

Surely for the depression that comes with having no libido and ED, there must be a way mother nature balances this out so you dont have to live depressed for the next 50 odd years of your life. Im talking more about young guys who are in their 20's. It sounds morbid but I hope im not around for another 50 years in the state I am in. This post is a little bit of a vent I guess. I took finasteride and am so far totally refractory to any treatment. Total ED, Peyronnies Disease, shrinkage, zero libido.....baah!!!..... Relationships are crumbling around me and im over it. Screw putting up with this for the next 40 years.

What you just posted sounds to me like depression that should be much easier to deal with or would disapper all together after you keep your T, E and FreeT3 levels in check for 6 months to a year.
Do not set a goal about ED, in my case that is another problem that is much easier to deal with whem a mill stone of depression is off the chest.

[Megazoid]

Jaydee, please check out my reply in your other thread. You will beat this, trust me.

[Sunkist]

Originally Posted by jaydee

If you are a non responder to TRT, will the health risks of having low T still apply to you? Or is it that if you show on blood tests or urines that your T is at the appropriate level, the testosterone must be doing its job. What if there is a receptor problem or somthing?

Surely for the depression that comes with having no libido and ED, there must be a way mother nature balances this out so you dont have to live depressed for the next 50 odd years of your life. Im talking more about young guys who are in their 20's. It sounds morbid but I hope im not around for another 50 years in the state I am in. This post is a little bit of a vent I guess. I took finasteride and am so far totally refractory to any treatment. Total ED, Peyronnies Disease, shrinkage, zero libido.....baah!!!..... Relationships are crumbling around me and im over it. Screw putting up with this for the next 40 years.

I am trying to make sense of this. Are you saying that you have normal levels of Testosterone, but have libido and ED problems, or are your T levels low for your age.

Anyway T has no DIRECT influence on what you seek. The problem is vastly more complex and you need to reread some of Marianco's stuff on brain chemistry. T is the foundation, but not the solution.

[jaydee]

Originally Posted by Sunkist

Anyway T has no DIRECT influence on what you seek. The problem is vastly more complex and you need to reread some of Marianco's stuff on brain chemistry. T is the foundation, but not the solution.

Can you please elaborate on this?

My T level is very high, yet E seems to be in check and I still have no libido and ED...at all.

[jaydee]

Sunkist is there any particular thread that you can point to that on this topic of brain chemistry by Dr Marianco? I am looking through myself, but it could take me forever to find it.

[zkt]

This is not the one Sunkist refered to, but still a good reference on the subject.
http://www.benbest.com/science/anatmind/anatmd10.html
and maybe this:
http://www.fi.edu/brain/stress.htm#top

[JanSz]

Originally Posted by jaydee

Sunkist is there any particular thread that you can point to that on this topic of brain chemistry by Dr Marianco? I am looking through myself, but it could take me forever to find it.

I am guessing that when Dr Marianco made the list below, he did that in sequence of how often each item appeared in his practice.

http://forum.mesomorphosis.com/522135-post3.html
The hormones that can influence libido directly or indirectly include:
Testosterone
Dihydrotestosterone
Estradiol and other estrogens
Progesterone
DHEA
Cortisol
Aldosterone
Pregnenolone
Thyroid Hormones
Insulin
Glucagon
IGF-1
Growth Hormone
Melatonin
Vasopressin
Calcitonin
TSH
LH
FSH
GHRH
Prolactin
CRH
ACTH
TRH
Epinephrine
Norepinephrine
Dopamine
Serotonin
Oxytocin
Endorphins
Somatostatin
Renin
EPO
Angiotensins
etc.etc. (practically every hormone)

Of course, some have greater influence than others. But all are involved in a tight mesh of function. Abnormalities in one can permeate the entire system, causing problems with the others.
__________________

[jaydee]

Thanks for those links zkt, some interesting stuff in there.

Janz that is quite a list. It would cost a fortune...lol....cheers. He is very comprehensive.

[JanSz]

Originally Posted by jaydee

Thanks for those links zkt, some interesting stuff in there.

Janz that is quite a list. It would cost a fortune...lol....cheers. He is very comprehensive.

It cost $3500
all paid by insurance.