Reverse T negative feedback

[zkt]

Since pregnenolone is the adrenal precursor of testosterone, seems to me you are contaminating the results of your test by taking both Baclofen and pregnenolone during the test.

[zumper]

Just take only the Bac.In these doses won't be such sedating.
You have to see the results with the Bac only.
Preg is an hormone and the bet here is a restart without hormones.

[gwynnsh]

Have you heard of a product called AIFM (Aromatase Inhibator for men) that's a natural (non-prescription inhibitor? The details: AI for Men uses ATD, a natural steroidal aromatase inhibitor, that is better suited for men than the most commonly used AI’s like arimidex and letrozole which were designed for women. It provides adrenal and immune supports as well as cortisol suppression through the addition of Dehydroepiandrosterone. This product is designed for men only.
Sounds like it may actually help with my situation.

[eeso]

i agree - u should only take bac. Leave the preg alone. If u take anything other than bac then the entire experiment is contaminated and no one will give it much credit. If this works I want my doctor to see it and not see a massive flaw in the trial.

[Jtay]

ZKT, Zumper, EESO,

Yes, I realize my personal trial would be better served with a Bac only baseline test result before proceeding with the Bac/T (or other steroid hormone such as Preg) test.

However, as I stated in a prior post, my time is limited as I will leave for Brazil the first week in October and I hope to have a protocol of which I will follow during my 6-8 months there. That means I have less than tow months to try and sort this out. Therefore, I had to consider the most important thing to me which is...can I take exogenous T, Preg, Estrogen, or other steroid hormones without the typical negative feedback of same which is why I decided to go ahead and include Preg in my initial trial.

If Bac fails to prevent Preg negative feedback, then I will try T, then estrogen (my estrogen is also low) to see if Bac prevents negative feedback regarding same.

Rest assured, i feel the same as you. However, I see no way around it. Unlike a preliminary trial with Bac only, it should not take long to determine if Bac does, or does not, prevent or reverse T (steroid hormone) negative feedback.

Regards,

[zumper]

Originally Posted by Jtay

ZKT, Zumper, EESO,

Yes, I realize my personal trial would be better served with a Bac only baseline test result before proceeding with the Bac/T (or other steroid hormone such as Preg) test.

However, as I stated in a prior post, my time is limited as I will leave for Brazil the first week in October and I hope to have a protocol of which I will follow during my 6-8 months there. That means I have less than tow months to try and sort this out. Therefore, I had to consider the most important thing to me which is...can I take exogenous T, Preg, Estrogen, or other steroid hormones without the typical negative feedback of same which is why I decided to go ahead and include Preg in my initial trial.

If Bac fails to prevent Preg negative feedback, then I will try T, then estrogen (my estrogen is also low) to see if Bac prevents negative feedback regarding same.

Rest assured, i feel the same as you. However, I see no way around it. Unlike a preliminary trial with Bac only, it should not take long to determine if Bac does, or does not, prevent or reverse T (steroid hormone) negative feedback.

Regards,

It's simple my man.You should try the Bac only to see LH,FSH And your T values.So you can know, and be able to speak, about what this medication can do clearly.
Then..go to see about the negative feedback issues and such.
All of us wait for this.If is there a chance, for a medicine like Bac ,to replace the well-known used till now medicines and not just to be able take exogenous T and have a healthy LH.
The key is to have all our hormones natural.LH,FSH,GNRH And Testosterone..

[eeso]

Yes, I eagerly await this because I am borderline low test. I could potentially just take bac (if it works) and not even need to take anything else. All I need is a bit of a boost, but currently my only option is full on TRT.

Could u not take bac on its own for 1 month then have labs done, then take preg from then on?

[zkt]

You are shooting yourself in the foot bro. Your tests will be contaminated and no one will give your results credence. Get a baseline T, FSH, LH the best way you can- do the Baclofen and retest. Anyone who has taken statistics 101 knows not to mix up variables as you are intending to do.

[Jtay]

I wished it were as simple as I hoped it would be, but I should have known better. Actually, there is a more in-depth reason for my madness of which I'm not sure can be overcome within my short time-frame left here in the States.

As I have stated before, I and many scientists believe that an anti-aging medicine breakthrough will occur in the areas I have discussed here on this thread. In fact, a partial breakthrough has already occurred of which most here are unaware of with the opioid antagonist drugs, Naloxone, Naltrexone and Nalmefene which share commonality with Bac:

Most of hese drugs have already shown in numerous studies to increase LH and T: Here is a link to one such study:

http://humrep.oxfordjournals.org/cgi...ract/8/10/1598

Therefore, the breakthrough that has occurred is that there are indeed drugs available that can naturally increase LH and T levels. However, the reason this is not widely publicized or known in the medical establishment is there is one piece of the puzzle that remains unsolved...and it's a big one that also many negatively effect Bac use.

The problem is, just about all of the drugs including Bac, decrease the body's ability to utilize dopamine. For those that don't know, dopamine is the main culprit pertaining to Ed/libido. As your body ability to process or manufacture dopamine diminishes thus so does your libido.

All one has to do is google dopamine and Bac and you will see that Bac increases dopamine in the brain because it diminishes effective utilization of same. Not unlike when your body becomes insulin resistant you have an increased amount of insulin in your system because your body has quit utilizing insulin effectively.

Therefore, with no intent to undermine the importance of a non-corrupted baseline test, I knew going into my personal Bac trial that I would have to overcome the aforementioned dopamine negative. My excitement that I had found an inexpensive drug that may mimic the effects of the much more expensive drugs named herein resulted in my posting prematurly certain aspects of my trial.

There currently is a race on with several scientists doing various studies trying to unlock this missing link as the LH/T link has already been unlocked. I am one such person in this race to find the missing link. Just about all agree that the missing link will probably be a result of combining several drugs, however, the naltrexone study suggest that it may be a time/dosing issue .

Therefore, my decision not to try Bac alone was knowing that yes, we stood a decent chance of success in raising LH/T but possibly at the expense of something much more important to me, libido. A combination of Bac and Preg seemed to be a good choice as Preg has been shown in some tests to mediate dopamine. However, to no surprise, while I can already see and feel a positive difference, my libido has indeed been diminished but still too early for definite conclusion.

One of the things that is now being tested in naltrexone is the dosing. If you take it as I am now raking Bac is has a negative effect on endorphines and Dopamine. However, if you take it in low doses at night then it has a complete opposite effect.

http://www.lowdosenaltrexone.org/index.htm.

Therefore, there is a chance that my spreading Bac throughout the day is actually encouraging the negative dopamone utilization (reduced libido) whereas, if I were to take it only one time at night, then it may give the body time to utilize the extra dopamine in my brain during the day which may actually increase libido. Yes, I know that the low dose naltrexone is mainly referring to endophines. However, if you study endorphines you will see that there is relation to dopamine as well.

So where do I go from here?

I will let you know. I am studying night and day to try and determine my next move. There are some very interesting things that I am considering.

Regards,

[Jtay]

Originally Posted by gwynnsh

Have you heard of a product called AIFM (Aromatase Inhibator for men) that's a natural (non-prescription inhibitor? The details: AI for Men uses ATD, a natural steroidal aromatase inhibitor, that is better suited for men than the most commonly used AI’s like arimidex and letrozole which were designed for women. It provides adrenal and immune supports as well as cortisol suppression through the addition of Dehydroepiandrosterone. This product is designed for men only.
Sounds like it may actually help with my situation.

I have not forgotten about you. I will post answer this week. My schedule is hectic right now.

[Jtay]

PS: One of my considerations is trying the low dose naltrexone as I happen to have a prescription of the 50mg tabs here with me. However, I would have to figure out a way to make 10-5mg portions out of each tab.

Endorphines (and dopamine) have long correlated to sexual performance. Naltrexone is already known to increase LH and T thus, it makes one wonder if you could get that benefit at night while asleep and the increased b endorphine (libido) benefit while awake. The best of both worlds maybe.

These docs/scientists may have come up with the anti-aging missing link without fully realizing it yet. It may be worth a try as when I tried Naltrexone before at recommended does it diminsihed my libido just as Bac seems to be doing now.

For those interested in anti-aging medicine, you really should read the link in my prior post on low dose Naltrexone as you will better understand just how close science really is to finding that missing link.

[Jtay]

Interesting article:

Look out, men: Testosterone is under attack

http://www.msnbc.msn.com/id/20302363/

[Jtay]

Note:The below para states B-Endorphins can stimulate dopamine by inhibiting production of GABA because GABA normally inhibits dopamine. Remember, Baclofen is a GABA B receptor agonist which basically means it mimics GABA's actions in the B receptor. Remember, we had talked about GHB when I first began this thread? The beauty of GHB was that it did all the great things Bac can do and also stimulated dopamine, in lieu of reducing dopamine like Bac, which is why it became a drug of choice. People liked the results! Anyway, when you read the below para, it may very well be that the doctors/scientists in the link I gave you before regarding low dose naltrexone may have discovered the missing link to anti-aging. Hmmmmm....Take low dose Naltrexone at night to increase LH and T while you sleep, by the time you wake up the Naltrexone has worn off and you get a huge upregulation of B-Endorphine and resulting dopamine. If true, sounds like they in a way have duplicated the good results of GHB. I'll post the link again at the end of this post FYI. Open for discussion....Man is this stuff interesting!!!!


"Dopamine is a brain chemical (i.e., neurotransmitter) involved in reward and reinforcement processes, and the NAc is a brain region involved in mediating alcohol's positive reinforcing effects. β-Endorphine (B-EP) is produced in the arcuate nucleus of the hypothalamus (ArcN) by nerve cells (i.e., neurons) that extend to other brain regions, including the ventral tegmental area (VTA) and the NAc. β-EP can stimulate dopamine release in the NAc through two mechanisms. First, it can interfere with (i.e., inhibit) neurons in the VTA that produce gamma-aminobutyric acid (GABA), a neurotransmitter that normally inhibits the dopamine-producing neurons in the VTA. Inhibition of GABA production leads to increased dopamine production and release in the NAc. Second, β-EP can directly stimulate (i.e., excite) dopamine-producing neurons in the NAc. Alcohol stimulates β-EP release in both the VTA and NAc. Purple structures indicate excitatory mechanisms, and gold structures indicate inhibitory mechanisms."

SOURCE: Adapted from Jamensky and Gianoulakis 1997.

Source: Gianoulakis, C. Alcohol-seeking behavior: The roles of the hypothalamic-pituitary-adrenal axis and the endogenous opioid system. Alcohol Health & Research World 22(3):202–210, 1998.

http://www.lowdosenaltrexone.org/index.htm

http://209.85.165.104/search?q=cache...lnk&cd=1&gl=us

[Jtay]

If you have not looked at my recent prior posts, you need to!

The more I study this, the more I believe that the doctors/scientists involved in low dose naltrexone (LDN) may have cracked the nut, I've been trying to crack here on this thread.

As I stated in a prior post, although the average person/doctor was unaware, science figured out a long time ago how to increase LH/T naturally via opioid antagonists. However, what they could not figure out was how to do it without resulting in loss of libido. If the LDN works as their studies indicate it does, they hvae not only figured out how to increase LH and T but also a big increase in libido, via dopamine, via B-endorphine. Wow!!! Lets hope it's true. I may be trying to reinvent the wheel here...Lol!

[Jtay]

I forgot to provide a link which makes all of this easy to understand:

http://links.jstor.org/sici?sici=002...ePage#abstract

Here it is in a nutshell:

1) Low Dose Naltrexone as you sleep:

B-Endorphins inhibit LH release and Naltrexone inhibits B-Endorphines which increases LH and Testosterone

2) Low Dose Naltrexone when it wears off by morning:

A huge upregulation in B-Endorphines which stimulate dopamine production which increases libido and may heal many diseases as noted on their web page:

* Bladder Cancer
* Breast Cancer
* Carcinoid
* Colon & Rectal Cancer
* Glioblastoma
* Liver Cancer
* Lung Cancer (Non-Small Cell)
* Lymphocytic Leukemia (chronic)
* Lymphoma (Hodgkin's and Non-Hodgkin's)
* Malignant Melanoma
* Multiple Myeloma
* Neuroblastoma
* Ovarian Cancer
* Pancreatic Cancer
* Prostate Cancer (untreated)
* Renal Cell Carcinoma
* Throat Cancer
* Uterine Cancer
* ALS (Lou Gehrig's Disease)
* Alzheimer's Disease
* Autism Spectrum Disorders
* Behcet's Disease
* Celiac Disease
* Chronic Fatigue Syndrome
* CREST syndrome
* Crohn's Disease
* Emphysema (COPD)
* Endometriosis
* Fibromyalgia
* HIV/AIDS
* Irritable Bowel Syndrome (IBS)
* Multiple Sclerosis (MS)
* Parkinson's Disease
* Pemphigoid
* Primary Lateral Sclerosis (PLS)
* Psoriasis
* Rheumatoid Arthritis
* Sarcoidosis
* Scleroderma
* Systemic Lupus (SLE)
* Transverse Myelitis
* Ulcerative Colitis
* Wegener's Granulomatosis