Selegeline

[Weatherlite]

Hope I didn't spell that wrong!

Been doing a bit of research into things which will actually help with sex drive as I really haven't had any results with regards to sex drive with my TRT. The Selegeline looks promising but I have a question about it. The research states that its effects are not reversible. Does this mean the effects are permanent? I know it is an MAOb inhibitor but if I stop taking it will the MAOb always be reduced or is it only short lived? These kinds of things I couldn't find and I would like to know as much as possible before I approach my doc about it.

thanks!

[The_Skeptic]

From what I understand, which is not saying much, it reverses itself in about two weeks.

[zkt]

The irreversiblity refers to the fact that the enzymes that bind to selegiline cannot be unbound. But since they are constantly produced the effect is apparent only while the selegiline is active. Th half life is 2 hrs. So if youre wondering if it makes a permanant change- no.

[engival]

been on it for 2 weeks, nothing yet!

[Vforcer2]

You may want to consider Test Pellet therapy since regular T therapy has not worked. Pellets IMHO is the best of the best in T therapy for sex drive restoration. However everyone responds differently.

[Weatherlite]

Well, for me it's not a matter of sex drive restoration but a matter of creating one in the first place. I have been hypogonadal my whole life but couldn't get a doc to even consider checking it til I was 26 and then they said nope because I was above the lower end of the range....by like 30 points! So anyway, I've never really had a sex drive...least not like normal men. I figure something didn't develop the way it was supposed to because of the low T during my teen years. Kinda hoping since TRT didn't work all that great that maybe the Selegline or Cabergoline might be an avenue to try.

[novice]

it increases mental energy, improves my memory, and puts me in a good mood. been taking just one mg transdermal for about 2 weeks now. i have not noticed an increase in libido or any improvement in sexual function from it.

[zkt]

Selegiline transdermal ? How do you do that ?

[engival]

hmm im hoping sele increases erection strength and libido

not sure if thats gonna happen though

[novice]

its in a alcohol based gel similar to angrogel and a compounding pharmacy is able to make it whatever dose desired.

[engival]

Selegiline, also known as l-deprenyl, is an irreversible and (relatively) selective MAO-B inhibitor.


1. What do they mean by Irreverisble, can someone explain this in easy text.

[zkt]

I was clinically brain dead when I asked that question.
And I thought I explained the irreversability befor. Maybe anoher thread. If I recall, all it means is that the biochemical bonds it causes cannot be broken. That is the reaction is not reversible as many are. Reactions causing vaso dialation and contraction, for instance. Not that it makes a permanant change in your biochemistry. The chemical bonds do fall apart over time and that is where the half life fits in. And besides MAO A and B is constant ly produced by I dont remember what.

Originally Posted by novice

its in a alcohol based gel similar to angrogel and a compounding pharmacy is able to make it whatever dose desired.

[engival]

hmm is that a good thing or bad thing???

i been on the stuff 2 weeks now, dont see a dam thing, but i havent gotten up to my maxium dosage of 1 cc

[zkt]

If it aint broke you cant fix it. Maybe you`re fine already ?

[engival]

no, i got bad fatigue, bad eD, and real bad PE