Seleginline + l-phenyalanine for Libido

[bullmastiff]

I am currently taking 5 milligrams of selegiline. I have found when I added
500 to 1000 milligrams of l-phenyalanine that I get in a powdered formula
from Life Extension my libido picks up quite a bit. The combination is better
than either is alone. I am having my testosterone tested tomorrow to see
if that has picked up my T levels. Will post the results.

[androjello]

Yes, do keep us updated.

[James]

I tried that and it didn't work at all.

Better note -- you need HIGH doses of vitamin B and C for the phenylalanine to metabolize in any siginificant way.

[bullmastiff]

I use a powdered drink made by Life Extension that has all the co-factors
that you need.

[bullmastiff]

blood test results

before levels 320 total testosterone (241-827)
36 free testosterone (34 - 194)

current levels 432 total testosterone
91 free testosterone

This was after being on the selegiline 5 mg for about a month. I believe
you can go as high as 10 mg a day. I'll have to see if Dr. Shippen has
a protocol for the use of this med. Also even though numbers are not that
high libido is as high or higher than when I was on androgel 5 grams and my
total test was 610 and free test was well over 100.

[frankwhardy]

Originally Posted by bullmastiff

blood test results

before levels 320 total testosterone (241-827)
36 free testosterone (34 - 194)

current levels 432 total testosterone
91 free testosterone

This was after being on the selegiline 5 mg for about a month. I believe
you can go as high as 10 mg a day. I'll have to see if Dr. Shippen has
a protocol for the use of this med. Also even though numbers are not that
high libido is as high or higher than when I was on androgel 5 grams and my
total test was 610 and free test was well over 100.

That's a very impressive percentage increase in free T. Since total T didn't go up nearly as much (%-wise), the implication is that SHBG dropped substantially. I'm wondering if the mechanism is that the selegiline increased IGF-1 (by improving sleep or whatever), since IGF-1 is known to exhibit an inverse relationship with SHBG. Does anyone have any before and after data while using selegiline for their IGF-1 levels (or even SHBG)? I'm trying to come up with a way, other than using HGH (expensive) or Danazol (dangerous), to lower my SHBG level (it consistently runs at 60-65 nmol/L), and finding a way to increase my low-normal IGF-1 (other than using HGH) looks like a theoretical possibility. Thanks,
Frank

[Matt Muscle]

Originally Posted by bullmastiff

I am currently taking 5 milligrams of selegiline. I have found when I added
500 to 1000 milligrams of l-phenyalanine that I get in a powdered formula
from Life Extension my libido picks up quite a bit. The combination is better
than either is alone. I am having my testosterone tested tomorrow to see
if that has picked up my T levels. Will post the results.

Hey Mate... interesting post.. I have tried some selegiline, initially I felt some boost to libido, but it wasnt very consistent... I did not however try it with l-phenyalanine.
Exactly what has it done to your libido... improved sensitivity? erection quality? how often you want to masturbate/have sex?

When I did try the selegiline, I found it quite speedy and it also brought on some anxiety... have you found any of this? Perhaps this dissipates with continued usage.
thanks.

[1cc]

[quote=Matt Muscle]
When I did try the selegiline, I found it quite speedy and it also brought on some anxiety... have you found any of this? QUOTE]

I had the same experience.

[Vforcer2]

Originally Posted by frankwhardy

That's a very impressive percentage increase in free T. Since total T didn't go up nearly as much (%-wise), the implication is that SHBG dropped substantially. I'm wondering if the mechanism is that the selegiline increased IGF-1 (by improving sleep or whatever), since IGF-1 is known to exhibit an inverse relationship with SHBG. Does anyone have any before and after data while using selegiline for their IGF-1 levels (or even SHBG)? I'm trying to come up with a way, other than using HGH (expensive) or Danazol (dangerous), to lower my SHBG level (it consistently runs at 60-65 nmol/L), and finding a way to increase my low-normal IGF-1 (other than using HGH) looks like a theoretical possibility. Thanks,
Frank

A Herb called Stinging Nettle Root has been shown to have a very positive effect on raising Free T levels. I can't remeber if it is thru binding itself to exisiting SHBG or if it actually lowers SHBG. There the supplement company that is developing a potent extract of this herb called Divanil. Stinging Nettle has a number of positive benefits besides raising Free T levels. Here is the link to the new product, which is still in beta phase right now(finished product available in about a month):
http://www.designersupps.com/static_site/activate.php

Here is an excellent description and properties of Stinging Nettle Root:
http://www.rain-tree.com/nettles.htm

I have been testing this product for about two weeks with no adverse side effects. My workouts have new life, and my night and morning erections have increased quite a bit. I am excited about the possibilities of using with HCG for HRT as a Protocol. I have tried Selegnine, without any adverse effects, but am a little leary of using a drug like that for prolong periods of time. When I used it, I only used 5mg EOD.

I am fairly certain I can create a nice and easy protocol to follow with the HCG and Nettle Root extract, that would yeild awesome results...the only thing that I am really missing is a
product to keep E2 under control. I have used Dimm and had not real benefit. It is my understanding that non steriodal AI like A-dex will shred my already poor Lipid profile.

If anyone has any ideas, please pass them on to me as I would prefer to not go back to the Test Cyp, especially for the rest of my life.

[frankwhardy]

Hi Vforcer2,

I've tried nettle extract before and I felt worse on it. I think (emphasis on "think") the problem for me is that while it apparently can increase free-T, either by lowering SHBG and/or blocking the T-receptors on the SHBG (I can't remember either), it also lowers estrogens. My baseline estrogens, including E2, are already lower-normal, so the nettle wasn't good for me. (The possibility exists, too, that I may just need to try another brand of nettle extract.) But you, on the other hand, may have inadvertently found yourself a good controller of E2. Your pickup in erections may be indicative of that (Phil and others have found a direct correlation between their E2 levels and erection facility; when E2 is either too high or too low, they have a problem). Here's an article from an herbal guy who talks more about nettle and its anti-estrogen potential: http://www.geocities.com/bill3320/hormones.html

Are you actually using the RainTree brand of nettle extract? Thanks,
Frank

[Vforcer2]

Hi Frank,

I am actually using the Activate Beta version from Designer Supplements, which is just nettle root right now, at 20 caps per day. When the final version is released, it is supposed to be more effective, and only require 4 caps per day or so.

I have experimented with some other products, that were steroidal compounds, that took my Total T to 902 (241-827), Free T to 45.9 (8.7-25.1), but pulled my E2 down to 17 (0-53), so my E2 was way to low and my libido was pretty much gone. I have never had ED problems, so that was not an issue. So, I went off the stuff, and at the end of week two my libido was coming back, and at week 3 and 4 was climbing quite a bit a I am sure my E2 was climbing back to normal.

I am going to take another blood test in a week or so to see how much the Nettle Root product has freed up my T, and where it puts my E2 as well.

When I first started TRT, my baseline E2 was high, and then after starting TRT my E2 went even higher. I have lost quite a bit of weight since then, so hopefully with less adipose tissue, I will not have E2 soar quite as high.

Thanks for the link, I will check it out. Nettle does have a powerfully positive effect on the prostate, which is a nice benefit.

[1cc]

Originally Posted by frankwhardy

I've tried nettle extract before and I felt worse on it.

Nettle also reduces DHT.

[frankwhardy]

Thanks Vforcer2 and 1cc,

I think you're right about the nettle reducing DHT, but I was eliminating that possibility because my baseline DHT is at the very upper end of normal (even though my baseline free-T is at the very lower end of normal, go figure; my baseline % free-T is actually well below normal). That seemed to only leave the possibility that the nettle lowered an already marginally low E2 (and total estrogens) as the reason it had a negative impact on me. Maybe I should give another brand a shot, though.
Frank