Shbg?

[saldivar]

What does SHBG in simplest terms do and why is it important or not?

Thanks

[chap]

...and where in the body is shbg produced, is it in a gland? and what modulates it's production?

[wildfox]

It binds T and makes un unusable in the body.

You might use google.com to learn more about it.

WF

[MANWHORE]

yeah do a simple search but lowering it can help results .. It's there for a purpose so you wouldn't want to lower it too much .. there are many things that lower it too or just bind it up .. Progest,DHT, .. many types of AAS

[cpeil2]

Originally Posted by chap

...and where in the body is shbg produced...

Liver.

[MANWHORE]

Originally Posted by cpeil2

Liver.

yes and probably why orals are so good at lowering it,like Anabolics 2005 says

[chap]

interesting thread here that shows that clomid raises free test well in younger men, but in older men it appears that most of the test ends up bound by SHBG, is there yet discovered a very effective way to combat SHBG binding?

http://forum.mesomorphosis.com/showt...d=1#post464839

[jboldman]

you need to be careful when making assumptions about shbg, it also acts as a resevoir for test. btw. it is a myth that shbg is responsible for decreasing test and increasing estro in older men.

jb

[MANWHORE]

SHBG doesn't decrease Test,it decreases FREE test and yes it does in older men because SHBG levels raise as we get older. SHBG wouldn't increase estrogen it would lower it but estrogen will increase SHBG so Estrogen increasing as we get older increases SHBG therefore decreasing FREE test .. So high Estrogen levels are a problem as we get older

[jboldman]

What you say seems to follow the local wisdom regrding shbg but it is a very complex subject. What you are saying is that as we get older, shbg acts as an estrogen "amplifier" taking free test out of circulation and increasing levels on non-bound estrogen. Please read this abstart and let me know what you think.

jb

===================

Associations of Sex-Hormone-Binding Globulin (SHBG) with Non-SHBG-Bound Levels of Testosterone and Estradiol in Independently Living Men
Willem de Ronde, Yvonne T. van der Schouw, Majon Muller, Diederick E. Grobbee, Louis J. G. Gooren, Huibert A. P. Pols and Frank H. de Jong
Department of Internal Medicine (W.d.R., H.A.P.P., F.H.d.J.), Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands; Julius Center for Health Sciences and
Results of in vitro experiments indicate that with increasing concentrations of SHBG, testosterone (T) is preferentially bound to SHBG in comparison with estradiol (E2). In these studies, the ratio of non-SHBG-bound E2 (non-SHBG-E2) to non-SHBG-T increased with increasing levels of SHBG. SHBG has consequently been regarded as an estrogen amplifier. In this cross-sectional study in 399 men aged between 40 and 80 yr we tested whether higher levels of SHBG are associated with a higher estrogen/androgen ratio in vivo. The mean T level of these men was in the eugonadal range [536 ± 152 ng/dl (18.6 ± 5.26 nmol/liter), mean ± SD]. With increasing SHBG levels the non-SHBG-bound fraction of T decreased from 80 to 36% and that of E2 from 89 to 53%. Higher levels of SHBG were associated with higher levels of both total T [regression coefficient (ß) after adjustment for age and body mass index, 286 ± 15.8; P < 0.001] and total E2 (ß = 4.47 ± 0.90; P < 0.001). However, SHBG levels were negatively related with levels of non-SHBG-E2 (ß = –1.78 ± 0.69; P < 0.001), whereas there was a positive association between levels of SHBG and non-SHBG-T (ß = 32.0 ± 9.78; P = 0.001). Furthermore, we observed a negative relationship between SHBG levels and the E2/T ratio of either total (ß = –0.016 ± 0.002; P < 0.001) or non-SHBG-bound (ß = –0.011 ± 0.002; P < 0.001) hormone. Therefore, we conclude that in eugonadal men, higher SHBG levels are associated with lower levels of non-SHBG-E2 but slightly higher levels of non-SHBG-T. This means that SHBG cannot be regarded as an estrogen amplifier in eugonadal men.

[pmgamer18]

Well in my case my Free T was always very low normal this was on going for a good 18 yrs. Four yrs. ago I read about high E2 Estradiol and had it tested I was up in the 90's what a Total T of 850. I went on Arimidex got my E2 down to 24 and my Free T shot up over the high normal. At the time I was 58 yrs. old.

[jboldman]

wouldn't that be consistent with arimidex inhibiting aromatase thus increasing levels of test?

[foreverstrong37]

Exactly what I was asking for. My total test is 937 but I still have symptoms of low test. Im suspecting estradiol is high. Im going to try arimidex also. However, Im going to at least ask my doctor for a estradiol test to see for sure before I take it. I hope he will at least check it.

[foreverstrong37]

PHIL, thanks for the post. 2 Questions for you.

1. Before you took arimidex and for those 18 years of low free test, did you have any signs of gyno (fat around your nipples), fluid retention, or low libido?

2. Did your libido improve when you took arimidex? and your free test shot up over 24?

Thanks

[pmgamer18]

Originally Posted by jboldman

wouldn't that be consistent with arimidex inhibiting aromatase thus increasing levels of test?

Not sure but I do know that E2 takes up the space in the cells and the T meds can't get in so your levels say low or your not able to use the T that is in your blood.