SWALE on new E2 drug.

[pmgamer18]

SWALE checked my Dr.'s office today and it is Faslodex a shot you get once a month to keep E down.
http://www.astrazeneca-us.com/module...lay.asp?id=284
One of the guys found this link yesterday.
Phil

[SWALE]

Thank you.

I'll be watching...

[stat1951]

Originally Posted by SWALE

Thank you.

I'll be watching...

SWALE,

Check Message 23 at this link for more info on Faslodex. Over on that thread, Phil refers to a study either being done or recently done here in the Cleveland area, a study that was conducted with this drug using males (hypogonadal males? males with gyno? males with breast cancer? males with prostate cancer?), however I can find absolutely no information on such a study.

Anyway, the link to the message with the info on Faslodex:

A New Type of Arimidex Coming out.

Here's one of the tests involving Faslodex (Fulvestrant) in the Cleveland area and it closed back in Dec., 2002:

http://www.clevelandclinic.org/cance...p?IDTrial=2765

Phase III Randomized Trial of Anastrozole vs Anastrozole and Fulvestrant as First Line Therapy for Post-Menopausal Women with Metastatic Breast Cancer...

Current testing around here all involve "menopausal women with breast cancer type situations:

At Cleveland Clinic,

"A Randomized, Open Label, Multicenter, Phase II Study Comparing the Effects of Proliferation and the Efficacy and Tolerability of Fulvestrant (FASLODEX) 500 mg with Fulvestrant (FASLODEX) 250 mg when given as Neoadjuvant Treatment in Postmenopausal Women with Estrogen Receptor Positive Breast Cancer"...

http://www.irelandcancercenter.org/C...ast-trials.htm

In Canton (south of Akron which is south of Cleveland), there's a research study going on to compare the efficacy of Faslodex (fulvestrant) to Aromasin (exemestane) in hormone receptor positive postmenopausal women with advanced breast cancer.

http://www.centerwatch.com/cgi-bin/c...&f=amcfoot.txt

The same study is also going on in Columbus:

http://www.centerwatch.com/cgi-bin/c...&f=amcfoot.txt

And in "various Ohio cities", a study to evaluate fulvestrant in the preliminary stage of breast cancer treatment and assess the relationship between dose, exposure, degree of reduction in tumor markers, and efficacy in postmenopausal women with estrogen receptor positive disease...

http://www.centerwatch.com/cgi-bin/c...&f=amcfoot.txt

But alas, nothing on a study involving males (actually not in the Cleveland area - or elsewhere that I could find offhand).

Can you check with your medical sources - or possibly Dr. Stevens direct (248-377-0600) - and ascertain more information on this study? The studies that I have located have dealt with menopausal women / women with breast cancer situations and all seem to indicate that Faslodex works on estrogen receptor sites and does not directly lower estrogen levels (though may have a positive effect obviously in reducing estrogenic activities).

It is obviously enticing that there "could" be an effective anti E medication that could be used once monthly via IM shot - but this also could simply be something of a wild goose chase in that it has certain benefits - even exceptional benefits in the right circumstances, but not necessarily what is needed for TRT cases in general (there always being the individual exceptions of course).

Larry

[stat1951]

Originally Posted by SWALE

Thank you.

I'll be watching...

Might want to check out this site also....

http://www.bodybuilderselite.com/Kno...ow/kid=10.html

Use/Dosing

Fulvestrant is administered using intramuscular injections. For the most part the full effects of the drug can be achieved using 250 milligrams per injection. Due to the active life of the compound these injections only have to be administered approximately once every four to five weeks. This is obviously a benefit when compared to the frequent dosing schedule that is required with aromatase inhibitors or selective estrogen receptor modulators.

At doses of 250 milligrams per month it has been shown that fulvestrant is just as effective as one milligram per day of anastrozole (3) or 2.5 milligrams per day of letrozole (4) at reducing estrogen in the body. It has also been demonstrated in clinical research that fulvestrant can be effective in the treatment of some estrogen-dependent breast cancers where tamoxifen citrate has failed (4, 5). This should indicate how powerful the compound truly is.

Risks/Side Effects

As is the case with most aromatase inhibitors, by effecting the action of estrogen is nearly all of the tissues of the body fulvestrant can have a negative effect on a user’s immune system in general and specifically, users will no doubt notice a detrimental effect on both their HDL and LDL cholesterol levels with this drug. So while it is true that fulvestrant does not eliminate estrogen from the body, or eliminate aromatization, it is true that it in fact stops most of its effects in the body, both positive and negative.

It is also true that this elimination of the estrogenic action in the body could lower a user’s libido, as is the case with some aromatase inhibitors. This obviously brings up a negative aspect of the extremely long active life of the compound. If one begins to experience any of the possible negative side effects associated with fulvestrant a user will not be able to adjust their dosages or cease administering the compound until it clears their system. This can take weeks depending at what time the last injection was done. Obviously this is something that should be taken into consideration when determining whether or not to use this compound.

Larry

[pmgamer18]

Good point and is just what I asked my Dr. about he feels that the way the study was going this will not be a problem. I do know of men taking one mg of Arimidex a day and I have been for some time now. I try lowering to .5 but end up back on one mg. So now doing shots every 3 days IM we will see if E2 gets better.