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Originally Posted by masterpp i never used to understand why my e2 was so high when i was off gels, ie natural hypergonadal. but from another post, someone explained that excess lh and fsh converts very quickly to estrogen, hence why when i was off trt my e2 was higher than when i was on it.
the second point, i could never understand why my dht was so high, but i had no sex drive. i used to think that it was because e2 was too high, but actually i believe the reverse is true, and that my gels cause dht conversion, and suppress e2 conversion, so im actually lacking e2 and may try rubbing some test on my stomach to see what happens
cheers |
Estradiol is made from testosterone via aromatase enzyme.
Luteinizing hormone increases testicular testosterone production.
Luteinizing hormone also increases aromatase enzyme production, leading to a converstion of testosterone to Estradiol.
Estradiol is as much as 10,000 times more potent than testosterone in its effects. It is a fine balance that needs to be done at small levels, to maintain function with estradiol in men. Too little or too much will impair functioning.
The brain measures how much testosterone (with the help of progesterone) and estradiol to determine how much Luteinizing hormone to produce. This is the negative feedback mechanism. If there is too much testosterone and estradiol together, then LH production is lowered.
Dihydrotestosterone is made from testosterone via the alpha-reductase enzyme.
Dihydrotestosterone is about 7 times more potent than testosterone at testosterone receptors (except in muscle - which is why dihydrotestosterone is not anabolic).
Since Dihydrotestosterone is more potent than testosterone, it can make the brain think there is enough testosterone so that it reduces LH production, leading to a reduction in testosterone production, and hence estradiol production.
Dihydrotestosterone may inhibit the aromatase enzyme - but I am not sure of this point - to reduce estradiol conversion from testosterone.
Dihydrotestosterone can do some things the opposite of testosterone. For example, it can increase abdominal fat - rather than reduce abdominal fat as testosterone does. It can cause scalp hair loss as opposed to hair growth as testosterone can. Dihydrotestosterone can cause insulin resistance as opposed to reducing insulin resistance.
Dihydrotestosterone can either improve function or impair function - it can be a good hormone or bad hormone. Because of this dual nature of
DHT, I prefer to minimize its production to avoid negative side effects.
Having a lot of body hair indicates there is a lot of alpha-reductase in the skin.
DHT does promote body hair growth (not scalp hair growth).
If a reduction in
DHT production is desired, then testosterone injections or pellets are the preferred route of administration.
If
DHT acts as a good hormone, then transdermal gels or creams can be used. It is up to the physician and patien to decide if this is happening.
10-29-2006, 05:23 PM
two interesting things ve learnt 
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