Adrenal Fatigue and Wilson's Glandular Extracts

[cjones]

Isocort is tiny pellets 90% for cortisone and the rest is trace amount to make it up as a "suppliment" while the glandulars idea is to support general adrenal function for all the other hormones (androstenedione, aldosterone, corticosterone, progesterone etc) There are so many that I couldn't list them all without doing a search... Aldosterone and Cortisol are the key players you always need - Adrenal Extra (whole bovine glandular) for example provides all the enzymes and hormones to support your own adrenal function

Another thing is high DHEA and low cortisol being a bad sign and that taking cortisol suppresses dhea so people seem to suppliment this. Not an ideal situation but cortisol is essential for life

I guess its going for better and not perfect with severely depleted adrenal function for a better quality of life. When something isn't working properly or is already suppressed you have to lose some of the anxietys with taking cortisone.

It is interesting Nutri-meds now also do an adrenal cortex glandular were all the different steroids are secreted... Some interesting info at the website below

Adrenal Steroids

[pmgamer18]

The thing I don't like about adrenal glandulars is you have no idea what is in them they can be full of Adenine and God knows what else. I tried them for 6 months the stopped and I felt they did more harm then good. I then did Isocort you would save your self a lot of time trying to get better if you tried this. I later went to HC Cortef wow it was like day and night I felt so much better. And that feeling you had that put you in the ER if you had some HC and stress dosed it your would have got past this. I must stress does when I over do it or I would be in the ER. Also I don't get bronchitis anymore and when I feel ike I am comming down with something I stress dose my HC and get passed it. You have the book read it it's dam good. As long as you don't do more the 30mgs of HC your will not do any harm most do good on 20 mgs. I do 25 mgs.

Originally Posted by s0b

I started on the adrenal glandulars 3 days ago, along with the Adrenal C Formula and Panothenic Acid and Vitamin B12 some times because i am very low on that.

I gave it a lot of thought, and considering the fact that i tried one steroid before and it messed me up severely (finasteride) i hesitated to start on hydrocortisone right away.

Yet i bought some hydrocortisone and also ordered the safe uses of cortisol book, in case those glandulars dont help at all.

I guess i will go ahead and keep on them glandulars for 2-3 months at the most and see how it goes.

Yesterday i returned to the basketball court after 8 months. I managed to play for about 15-20 minutes, my breathing was ok, no bronchitis, but temperature was very low and i was not being able to sweat at all despite all the running around i did. I understand its a long process to get back in track.

Deep inside me i think that the worst period of adrenal fatigue has subsided, i dont have any pupil problems any longer, last time a had a serious hypoglycemia was about 3-4 weeks ago and i sort of feel excited sometimes during the day for things that all those 8 months were totally forbidden, like going out and having some sip with friends and a long conversation, all these things were very hard for me to do before, i felt so ill and weak to even listen to people talking.

I also dont spend most of my day in bed, rather walk around my house and play with my comp or read a book now and then. I also drive around more.

I dont feel the glandulars have done anything till now, i think the vitamins help more, but this improvement can also be due to the long rest in bed (8 months is not a small period of time)- sometime my body had to start showing some improvement. The only thing that worries me is whether i will be able to lift weights again or not, the one part of my body that has been seriously damaged all this time are my arm muscles, some of them have atrophied and i feel that my grasping and lifting strength has is very low. Maybe when my metabolism gets better and i feel my overall body strength to increase i will try doing minor weight lifting ( i expect that in 3-4 months at the soonest).

*Last time i tried lifting weights 3-4 months ago i ended up in hospital crying for help. I got shaky, trembling and so insomnic. I barely slept 2-3 hours a day and my sensitivity to sounds and frustration was so terrible. I didnt know of adrenal fatigue back then, thought it was all due to overtraining. Nor did my doctros know of anything related to that, they thought i was neurasthenic and kept me in neurology clinic with antidepressants and anholytics. Now i look back at this time and laugh some times.

I feel sorry for all these people that develop metabolic issues but dont know whats wrong with them and end up in neurology clinics. Its spectacular how adrenal fatigue or other metabolic/hormonal issues can manifest themselves as neurasthenia or depression and confuse the average doctor

[pmgamer18]

Originally Posted by Megazoid

Chris, what other hormones do the adrenals produce?

Here read this it helped me to find out my Adosterone levels were low.
Adrenal Glands
Also STTM's did a FAQ's on Adrenals full of links.
Stop The Thyroid Madness » ADRENALS FAQ–the most frequently asked questions

[cjones]

Originally Posted by pmgamer18

The thing I don't like about adrenal glandulars is you have no idea what is in them they can be full of Adenine and God knows what else. I tried them for 6 months the stopped and I felt they did more harm then good. I then did Isocort you would save your self a lot of time trying to get better if you tried this.

Phil this is why I said about Nutri-meds now having a freeze dried adrenal cortex glandular that is not were adrenaline is made. The explanation of the adrenal cortex below says a lot about the effect cortisol has on your mental health

Adrenal medulla
As its name suggests, the adrenal medulla is the central core of the adrenal gland, surrounded by the adrenal cortex. The chromaffin cells of the medulla are the body's main source of the catecholamine hormones adrenaline (epinephrine) and noradrenaline (norepinephrine). These water-soluble hormones, derived from the amino acid tyrosine, are part of the fight-or-flight response initiated by the sympathetic nervous system. The adrenal medulla can be considered specialized ganglia of the sympathetic nervous system, lacking distinct synapses, instead releasing secretions directly into the blood.

Adrenal cortex

By contrast, the adrenal cortex is devoted to the synthesis of corticosteroid hormones from cholesterol. Some cells belong to the hypothalamic-pituitary-adrenal axis and are the source of cortisol synthesis. Other cortical cells produce androgens such as testosterone, while some regulate water and electrolyte concentrations by secreting aldosterone. In contrast to the direct innervation of the medulla, the cortex is regulated by neuroendocrine hormones secreted by the pituitary gland and hypothalamus, as well as by the renin-angiotensin system.

Adrenal gland - Wikipedia, the free encyclopedia

[pmgamer18]

I believe I read this on a post by Dr. M most don't say there supplement is made from adrenal they just say glandular there was one my wifes Dr. gave here was full of adrenaline.

Originally Posted by cjones

Phil this is why I said about Nutri-meds now having a freeze dried adrenal cortex glandular that is not were adrenaline is made. The explanation of the adrenal cortex below says a lot about the effect cortisol has on your mental health

Adrenal medulla
As its name suggests, the adrenal medulla is the central core of the adrenal gland, surrounded by the adrenal cortex. The chromaffin cells of the medulla are the body's main source of the catecholamine hormones adrenaline (epinephrine) and noradrenaline (norepinephrine). These water-soluble hormones, derived from the amino acid tyrosine, are part of the fight-or-flight response initiated by the sympathetic nervous system. The adrenal medulla can be considered specialized ganglia of the sympathetic nervous system, lacking distinct synapses, instead releasing secretions directly into the blood.

Adrenal cortex

By contrast, the adrenal cortex is devoted to the synthesis of corticosteroid hormones from cholesterol. Some cells belong to the hypothalamic-pituitary-adrenal axis and are the source of cortisol synthesis. Other cortical cells produce androgens such as testosterone, while some regulate water and electrolyte concentrations by secreting aldosterone. In contrast to the direct innervation of the medulla, the cortex is regulated by neuroendocrine hormones secreted by the pituitary gland and hypothalamus, as well as by the renin-angiotensin system.

Adrenal gland - Wikipedia, the free encyclopedia

[s0b]

Thanks pmgamer, I will look at this Isocort definately, as i dont want to interfere with my adrenal medulla synthesis.

As i have stated majority of my problems are due to excess sympathetic activity and high norepinephrine synthesis and release. Yet i dont know what should adrenaline do in my case, whether it should rise or fall.
The doctors who tested me for this failed to do the tests correctly and the only thing i have is the supine hormone levels at rest and then supine hormone levels after exercise(which was not that precise of measurment either-but yet it shows how some hormones react). Yet i lack the 10 minute standing blood catecholamine testing which is crucial for people who suffer from overtraining or adrenal fatigue due to excess chronic physical stress

Thus most of the protocol was wrong. In order for proper catecholamine testing one needs to lie in bed for 20 minutes (relax) then get blood drawn for adr/noradrenaline test then stand up and at about 10-12 minutes get blood drawn and retested again. Then you can repeat that testing after mild running and then after some resistance exercise, or some chinups.

It is also very important to have your blood drawn by a safety butterfly needle inserted some time ahead of testing instead of getting poked each and everytime which desensitizes the hormone level measurement more.

Anyways, if i could find a place to get ideally tested i would know exactly what supplement and how much to take, whether it could be hydrocortisone or isocort of whatever.

Concerning the adrenal extracts (i m currently taking wilsons -1 to 2 caps per day-). I was in a dillema initially but then thought i would just go ahead and use them (since i bought them) and see how it goes. I will have the cortisol book by two-three weeks time and decide whether i should jump to something else or not. TIll now however i havent noticed any adverse results-or positive either.
On the other hand when i tried using some siberian ginseng(which is suggested for adrenal fatigue users along with licorice) i got fired up so much, my pulse rate started going mad and i had a headache for three days. I felt my temperature rise seriously and the feeling of well being was there for sure but i had such a strong headache that i had to quit it. Thus i feel i will come to know if those adrenal extracts promote at least noradrenaline synthesis, since i am very sensitive to even slight level increases. (dont forget my resting levels are way above normal)

Really marianco would be of a great help if he could post here.
I have spend 450-500USD on neuroendocrinology and sport endocrinology books just to find and read three or four pages for them hormones and how they react in the overtrained individual. Its just so sad that there has been so limited research on this subject

[eeso]

Fatigued to Fantastic: Adrenal Stress End is pretty good.

But for actually treatment go for isocort - I have some on the way now!

[pmgamer18]

One problem we all have is getting the right tests and see the right Dr. it looks to me if you have a problem out of the main stream you in for a hard way to go and a long way to get there.

[cjones]

Phil before your accident did you feel perfectly ok? I find it hard figuring how I ended up like this other than maybe being born with "weak adrenals" that may have give way as soon as life really started. I am scared of being alone and this is a really lonely illness

[pmgamer18]

I was an animal at age 39 worked 58 hrs a week then come home and worked around the house I was allways doing something at my house or my familys house's. Went to the gym 5 days a week but the gym was at work I went at lunch time. Never would I come home and watch TV like I do now. I would jump my wife 5 days a week.

After the auto accident first thing that went wrong was I started losing my balance and in time like 4 months I started falling down. Went from Dr. to Dr. had all kinds of tests told every dam Dr. I hit my head hard in the roof of the car no seat belt law in them days. Dr.'s told me I had Ménière’s disease. Later that yr. I had pneumonia and I lost the feeling and use of my left side of my body. See a brain Dr. he told me I had inflammation of the brain and my Antibodies were keeping the inflammation in check but coming down with pneumonia was to much. He said I was lucky I seen him I could have died my brain was swelling he treated it with some steroides. I was fine in 2 weeks and back to work. But little by little I was becoming more and more fatigued and feeling stressed out unable to sleep and started having panic attacks. I pushed my self until I could not get out of bed. Back to more Dr.'s and they never got it right. I never stoped telling them this stated after a bad auto accident. Here I am on sick leave from work and the dam Dr.'s tell me they can't find anything wrong and told my I am suffering from major Depression so for the next 5 yrs I was all doped up on AD drugs never getting better. Then after all this my BCBS wanted to know why I was not getting better the dam Dr. tells them I don't want to get better I like being depressed will this put me in trouble with my Job and my Wife.

Just when everything was coming down on me a Dr. found me to have low testosterone I still have a copy of the tests. And still they did not get it right he said I had Primary low T. I mean WTF you can now look back at my labs and they were screaming Secondary low T a pituitary probelm.

Originally Posted by cjones

Phil before your accident did you feel perfectly ok? I find it hard figuring how I ended up like this other than maybe being born with "weak adrenals" that may have give way as soon as life really started. I am scared of being alone and this is a really lonely illness