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Old 01-09-2006, 09:01 PM
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Default Anyone ever find more than 1mg arimidex...

Anyone here ever find that more than 1mg per day of arimidex ends up being their optimum dosage? I have found that for me 1 mg is much better than .5 mg per day, and wonder if I should be experimenting with 1.5 mg /day to see if that might work even better still?

For some reason I believe I have extremely high aromatase levels, and arimidex really does the trick for me.
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Old 01-09-2006, 09:04 PM
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It may be. I have seen it. For you, it is especially important to monitor estrogen levels. I would use 24 hour urinary testing, and also keep track of the estrogen metabolites.

But yours, if that is truly how much it takes, is a very high dose compared to most. In fact, I would hazard a guess only 1/5th (maybe even less) of my TRT patients need any E control.
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Old 01-09-2006, 09:26 PM
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Thanks Swale, I had used steroids for many years and didn't do proper pct many times and for some reason I think that upregulated my aromatase production permanently?

It seems any exogenous test I take in is aromatized if I don't take AI, and that coupled with the fact that I am on a fairly high test dosage regimen (over 200mg a week) probably explains why the arimidex dosage is noticeably more effective at the higher dose compared to a more "normal" dosage.

I am glad to hear you have seen it, and I have learned something new again from you in that urinary estrogen testing would be an option. Need to look into some labs (I am not in USA).

Thanks again.
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Old 01-09-2006, 09:47 PM
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"I had used steroids for many years and didn't do proper pct many times and for some reason I think that upregulated my aromatase production permanently?"

I think there is something to that. I wish I understood why.
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Old 01-09-2006, 10:15 PM
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I was surprised to discover that 1mg of Arimidex in men only reduces estradiol by perhaps 50% on average. This is a good bit less than it is for postmenopausal women. Of course, women and men are very different.

Also of note is that .5mg/day and 1mg/day give similar results in this study.

http://jcem.endojournals.org/cgi/content/full/85/7/2370
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Old 01-10-2006, 02:42 AM
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nice abstract!

So the conclusion is that .5 mg and 1 mg per day are nearly the same, and there was no difference between 1mg and 3 mg per day, and only 50% or so estrogen suppression was able to take place with arimidex.

So those that are struggling so hard here to 'dial in' an exact arimidex dose may be way off the mark and stressing themselves out for nothing.
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Old 01-10-2006, 11:24 AM
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Quote:
Originally Posted by chap
nice abstract!

So the conclusion is that .5 mg and 1 mg per day are nearly the same, and there was no difference between 1mg and 3 mg per day, and only 50% or so estrogen suppression was able to take place with arimidex.

So those that are struggling so hard here to 'dial in' an exact arimidex dose may be way off the mark and stressing themselves out for nothing.
I think this is why my Dr. has me doing both Arimidex .5 mgs. morning and night and Indolplex/DIM with TMG. Doing this one blocks E2 and the other converts what does not get blocked. Still I feel it is a small price to pay to feel this good. I am hoping the new shot my DR. wants to try will help.
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Old 01-10-2006, 11:51 AM
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Quote:
Originally Posted by pmgamer18
I think this is why my Dr. has me doing both Arimidex .5 mgs. morning and night and Indolplex/DIM with TMG. Doing this one blocks E2 and the other converts what does not get blocked. Still I feel it is a small price to pay to feel this good. I am hoping the new shot my DR. wants to try will help.
http://www.astrazeneca-us.com/module...lay.asp?id=284
I wouldn't try the FASLODEX Phil. If it acts over such a long period, then it will be difficult to adjust the dose easily. Also, Rachel from the hypo group said that it is a suicide inhibitor like Aromasin, which means it permanently reduces Estrogen to an extent, even after you stop the drug. I don't think it is a good idea to take anything that makes irreversible changes.
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Old 01-11-2006, 02:31 PM
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Quote:
Originally Posted by mranak
I was surprised to discover that 1mg of Arimidex in men only reduces estradiol by perhaps 50% on average. This is a good bit less than it is for postmenopausal women. Of course, women and men are very different.

Also of note is that .5mg/day and 1mg/day give similar results in this study.

http://jcem.endojournals.org/cgi/content/full/85/7/2370
Thats a good one. It's in my Arimidex profile on steroid.com, but I mentioned it several years ago in an article I wrote called "ancillaries" which was (years) later posted on SynergyMuscle under "ABC's of Anti-E's"

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Originally Posted by SWALE
It may be. I have seen it.
Reputable medical journals apparently haven't seen it, as the study above, in men, elucidates.

Seen anything else that is clearly refuted by medical studies lately? Other than your writings?
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Old 01-11-2006, 04:54 PM
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Quote:
Originally Posted by 1cc
I wouldn't try the FASLODEX Phil. If it acts over such a long period, then it will be difficult to adjust the dose easily. Also, Rachel from the hypo group said that it is a suicide inhibitor like Aromasin, which means it permanently reduces Estrogen to an extent, even after you stop the drug. I don't think it is a good idea to take anything that makes irreversible changes.
I believe she is right buy it does not kill E's is kills aromatase enzyme and it is not perment the aromatase enzyme is replaced all the time. The dose I will start on will in most cases not be enough so testing one a month will tell how well it is working. Once we have the right dose. My E2 and Total E will be good for a month on the shot. So not the same as Aromasin Aromasin kills all he aromatase enzyme. Faslodex by dose kills some of them but now all.
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