arimidex dosing

[zkt]

Based on the concentration curve over time of T enanthate IM and the T1/2 of arimidex, it appears that Arimidex EOD might drive E2 levels too low in the latter part of the week. T reaches peak concentration rapidly in about 18 hrs. and begins to drop after 30 hrs. Higher doses would result in higher peaks and longer intervals. E2 peaks in step with T but remains high for about 2 days. This leads me to conlude that the first dose of Arimidex(T1/2=50hrs) is best taken 12 hrs after injection. The concentration curve is unknown but assumed that some time is needed to achieve maximum concentration.
The second dose is taken two days later at half strenght since the T concentration is falling during this time. During the last two days of the week E2 is naturally in the normal range. But his is when many take hcg.
Maximal plasma hCG levels will be reached in males approximately 6 and 16 hours after a single intramuscular or subcutaneous injection of hCG with a T1/2=33hrs. Considering this and assuming that 250iu hcg will result in T levels somewhat less that those achieved with T injectable, 1/2 the initial Arimidex dose seems appropriate on day 5. All things considered. 1/2 mg and 1/4 mg seems about right and I will begin following this regimen.

PREGNYL®
Arimidex (Anastrozole) clinical pharmacology - prescription drugs and medications at RxList
http://forum.mesomorphosis.com/attac...3&d=1139879356

[rick055]

I know this is an old thread (found it searching for arimidex in men), but did you do this?

Why not just .25 eod?

[zkt]

What a happy coincidence! I dont post much anymore but was typing a reply to Phils thread and noticed your reply second on the list and my name.
Yes I still stand behind what I said and even more emphatically now that I understand the biomechanics of arterial stenosis. I an not going to reference studies; they are abundant. suffice to say that low E is related to heart attack. Supressing E2 below normal values is statical suicide for much of the population. And really, who does blood tests that often to really have a handle in their levels?
You dont need a constant seerum level of aromatase inhibitor if you shoot T at a theraputic level. Roll with the punches. The medical profession doesnt utilize dose timing excep[t in the most rudimentary fashion because the public isnt up for it! But we can benefit by understinding the dynamics of the situition. Read, think, ask question, use your head.
I currently take 1/8 of a 2.5 femara tab 12 hrs after a 125mg IM T injection weekly.
Glad you brought this up.
To answer your question: you dont need a constant serum level and it is actually harmful to have one.

[rick055]

Originally Posted by zkt

What a happy coincidence! I dont post much anymore but was typing a reply to Phils thread and noticed your reply second on the list and my name.
Yes I still stand behind what I said and even more emphatically now that I understand the biomechanics of arterial stenosis. I an not going to reference studies; they are abundant. suffice to say that low E is related to heart attack. Supressing E2 below normal values is statical suicide for much of the population. And really, who does blood tests that often to really have a handle in their levels?
You dont need a constant seerum level of aromatase inhibitor if you shoot T at a theraputic level. Roll with the punches. The medical profession doesnt utilize dose timing excep[t in the most rudimentary fashion because the public isnt up for it! But we can benefit by understinding the dynamics of the situition. Read, think, ask question, use your head.
I currently take 1/8 of a 2.5 femara tab 12 hrs after a 125mg IM T injection weekly.
Glad you brought this up.
To answer your question: you dont need a constant serum level and it is actually harmful to have one.

When you say "below normal values", are you talking about below the absolute normal male reference range?

Also, do you do HCG before your T shot?

JOOC, what are your ballpark T / E levels?