Aromasin for E2 stops aromatase enzyme.

[pmgamer18]

Aromasin here is a post someone did saying it is a non-competitive inhibitor so it disables the aromatase enzyme permanently.

A cut & paste:
John Miller
Apr 24 2003, 4:53 pm show options

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From: sandcarr...@yahoo.com (John Miller) - Find messages by this author
Date: 24 Apr 2003 14:53:28 -0700
Local: Thurs, Apr 24 2003 4:53 pm
Subject: Exemestane(Aromasin) vs Anastrozole(Arimidex)
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There has been lots of talk about Arimidex but almost nothing about
Aromasin. If I understand it correctly Aromasin should be better/more
potent than Arimidex because it is a non-competitive inhibitor so it
disables the aromatase enzyme permanently (your body will keep make
more of course). So is there some reason to favor Arimidex over
Aromasin I'm not aware of?


Thanks, John



Patrick Arnold
Apr 25 2003, 11:38 am show options

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From: "Patrick Arnold" <parno...@ix.netcom.com> - Find messages by this author
Date: Fri, 25 Apr 2003 11:38:37 -0500
Local: Fri, Apr 25 2003 11:38 am
Subject: Re: Exemestane(Aromasin) vs Anastrozole(Arimidex)
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There is no reason to think that competitive is better than non-competitive.



"John Miller" <sandcarr...@yahoo.com> wrote in message


Now as it do more searching one poster says the Dr. Shippen favors Aromasin to combat estradiol.

A cut & paste.
Aromasin is what Shippen now prescribes to combat estradiol, and he is
an expert on the subject.

Here is what the Mayo Clinic say about it for women and men.
http://www.mayoclinic.com/health/can...atment/CA00039
Anyone try this.

[SWALE]

I do not favor the suicide inhibitor Aromasin over Arimidex at this time.

Has anyone heard why Dr. Shippen feels this way?

The notion that one is "more powerful" has no real meaning here, where there is a clear dose-dependen response. In either case, you titrate dose to effect.

[pmgamer18]

Originally Posted by SWALE

I do not favor the suicide inhibitor Aromasin over Arimidex at this time.

Has anyone heard why Dr. Shippen feels this way?

The notion that one is "more powerful" has no real meaning here, where there is a clear dose-dependen response. In either case, you titrate dose to effect.

I will see if I can find out more the post was 2004 a little old.

[SWALE]

Yes, "2004" is OLD in this field of medicine!

[gregxy]

Steroidal AIs like aromasim, ATD, or 6OXO can "fool" the
tests that are run to determine testosterone levels giving abnormally
high readings unless special test methods are used. Some of these compounds also convert into active byproducts (either other estrogens
or androgens). Arimidex should not have the same problems.

[maxzax]

I believe Shippen was still using Aromasin as of March 2005, I asked one Shippen's patients before about this before.

His response was Shippen thinks it's more effective than arimidex and it doesn't stay in your system as long, which he prefers.

I'm assuming that it doesn't stay as long, he means the half life??? but I am entirely sure. I also do not know what he means by it being more effective.

If one of Shippen's patients could find out, please let us know if he still prefers aromasin over arimidex? and why he prefers it if that's the case.

Thanks!

[Motomatt]

aromasim can "fool" the tests that are run to determine testosterone levels giving abnormally high readings

any more info on this ?

[gregxy]

There were a bunch of discussions on this over in the bodybuilding.com
suppliments forum. People use ATD which is closely related to
aromasim and see T levels > 1500. Some of this is caused by
increased T production, but some is due to ATD reacting with
reagents in the T test kit. Further searches for ATD in Pubmed show
that when using ATD reasearches used a chromatographic method
to separate out the ATD before measuring T levels.
ATD = androstatrienedione (with numbers that I forgot)

The same may not happen with aromasim, but it would be good to
keep in mind.

I think aromasim has a 1/2 life of about 8 hrs, but destroies the aromatase
instead of mearly binding to it. It then takes the body about 2 days to
make more aromatase so you should only need to take aromasim every
other day.

[SWALE]

Greg--that is interesting, and I thank you for posting it.

Let's research this important point. If true, it would eliminate Aromasin from consideration for TRT patients unless this issue can be overcome.

I just have not seen anything like that happen in a hundred or so patients on Arimidex. Perhaps it is diferent with other AI's though.

I will discuss this with a Lab Director friend of mine who is pretty darned sharp.

Something that may have happened is that all testosterone assays should be drawn into plain red top tubes. This is important with current assay methodology.

[gregxy]

John,

Another question for your friend the Lab Director is how large is the
variance in T levels from lab to lab. That is if I took the same
sample to all the labs how much woud the results vary.

If the variance were small then it would be possible to compare your
results to the ones in the "Sticky" at the top of the forum which was
taken from healthy individuals as opposed to the lab's reference range
which may include a substantial number of hypogonal patients. Using a
lab reference range only makes sence if the vast majority of patients
taking the test are known to be normal. This is probably not the case
for testosterone testing since doctors only test this on patients that
complain of problems like ED.

Greg