Men's Health Forum: This is a discussion on Daily Fluctuations in HCG Response Normal?? within the Anabolic Steroids forums, part of the extensive steroid information at MESO-Rx; Recently I noted something happening upon using a large dose of HCG . I am sure even you guys that ...
Recently I noted something happening upon using a large dose of HCG. I am sure even you guys that use if regularly and at small doses may have done a large jolt once or twice right? So maybe you know.
I pinned the HCG. For the sake of the argument it was a 2500 iu dose. IM or Sub-q same repsonse. The day after the injection, the holy nut explosion occurs and they are large, plump, and tender. BUT this response is cycling. Meaning that during the day my boys start to blow up around 10am and stay excessively plump till about 7pm. Then they subside down to a healthy and full size with little soreness. Then day two and again, 10am to 7pm they are monsters that feel like 16 year old blue balls, and gone at night. This will go on for as much as 4 days total post injection before this cycling of excessive swelling ends for good. There was no dosing in between and the only other drug being used is T-Cyp on 400mg/week basis. What gives? It sounds like Natural LH and FSH is signalling on top of the HCG, which should not happen while supping testosterone. More importantly, shouldn't LH and FSH rise in the night time is the body is cycling correctly, or is that not right? Help and thoughts please..
If you are pinning 400mg/week fo test I sincerely doubt it is FSH and LH causing the fluctuations.
I have ntoiced the same thing but with much smaller doses of hcg. I think alot of it has to do with time of day, temperature, environment, hcg half life, thyroid, etc.
I dont know. But I am pretty sure its not LH or FSH causing the issue.
I will go ahead and further note that I do take presciption amphetamines (Adderall) in the morning only. I am suspicious this activity is causing this but have not tested theory yet.
Well the adderall would explain some of your entertaining rants, but not the size fluctuations.
Yea, I thought that would mean something to a few of ya.... But what about night time rants?? Oh yea, alchohol.
Seriously, I am pretty sure that the use of amphetamines is completely underrated in our society due to that fact that all the ADD meds are exactly that. Amphetamines work on the kidneys and more relevant, the adrenals pretty hard. Thus completely skewing cortisol, DHEA, and probably our fundamental internal clocks!! Amphetamines drastically stimulate Norepinephrine, and Dopamine, and I have read some things lately being indicative of this having a strong effect on LH.. Just wondering if anyone else was looking at this and has some more to add.
And Rick, I am starting to think there is a direct corrolation of my ranting with Adderall use!! If I dont bugger off this forum and shut the hell up soon, I am going to have to flush them all....
The pituitary releases LH and FSH in pulses very similar to the release of ACTH but at several times thurout the day. It would appear that you are timing the hcg to act in sync with pituitary. It also appears that you are using too much hcg. Pretty sure problem will go away if you stop hcg. The half life of hcg is ~30 hrs: you dont need to do it every day. The standard guideline is more like 500iu at the end of the T IM cycle, on day 6 for instance and take it from there is needed.
But 400 mg TC/w and 2500iu/ed ? You might as well do AS. You will drive you E thru the roof, down regulate the LH receptors, atrophy the LH and FSH secreting cells in the anterior pituitary (shut down the HPT axis) eventually. How long you been on this regimin?
Yea the amphetamins throws everything into high gear.
Ya might wanna take stock of the situation and consider some serious readjustment of the drugs.
Quote:
Originally Posted by BBC3
Recently I noted something happening upon using a large dose of HCG. I am sure even you guys that use if regularly and at small doses may have done a large jolt once or twice right? So maybe you know.
I pinned the HCG. For the sake of the argument it was a 2500 iu dose. IM or Sub-q same repsonse. The day after the injection, the holy nut explosion occurs and they are large, plump, and tender. BUT this response is cycling. Meaning that during the day my boys start to blow up around 10am and stay excessively plump till about 7pm. Then they subside down to a healthy and full size with little soreness. Then day two and again, 10am to 7pm they are monsters that feel like 16 year old blue balls, and gone at night. This will go on for as much as 4 days total post injection before this cycling of excessive swelling ends for good. There was no dosing in between and the only other drug being used is T-Cyp on 400mg/week basis. What gives? It sounds like Natural LH and FSH is signalling on top of the HCG, which should not happen while supping testosterone. More importantly, shouldn't LH and FSH rise in the night time is the body is cycling correctly, or is that not right? Help and thoughts please..
__________________
Better Living Thru Understanding Biochemistry
I swear I have read HCG half-life is 3-4 days, but again I learn something...
PREGNYL®
RA 2400 ZA S1 (ref 1.0).
SCHEDULING STATUS:
S4
PROPRIETARY NAME
(and dosage form):
PREGNYL®
Pregnyl® 1 500 IU powder for solution for injection, provided with Solvent for Pregnyl
Pregnyl® 5 000 IU powder for solution for injection, provided with Solvent for Pregnyl
COMPOSITION
PREGNYL contains 1 500 and 5 000 I.U. Chorionic Gonadotrophin per ampoule
Each 1 mL ampoule of Solvent for Pregnyl contains 0,9% m/v sodium chloride in water for injection
PHARMACOLOGICAL ACTION
Pharmacodynamics
Pregnyl contains human Chorionic Gonadotrophin (hCG) which has luteotrophic (LH) activity.
In the female Pregnyl substitutes the endogenous mid-cycle LH surge to induce the final phase of follicular maturation, leading to ovulation.
In the male Pregnyl stimulates Leydig cells to promote the production of testosterone.
Pharmacokinetics
Maximal plasma hCG levels will be reached in males approximately 6 and 16 hours after a single intramuscular or subcutaneous injection of hCG, respectively and in females after approximately 20 hours. HCG is approximately 80 per cent metabolized, predominantly in the kidneys. Intramuscular and subcutaneous administration of hCG were found to be bioequivalent regarding the extent of absorption and the apparent elimination half-lives of approximately 33 hours. On basis of the recommended dose regimens and elimination half-life, cumulation is not expected to occur.
Preclinical safety data
No particulars.
the "Pulsing" action I was definitely suspect of and would agree for sure. I am also thinking that my circadium rythym is screwed beyond believe as shouldn't these pulses be occurring at night. It would tend to be explained by the fact that my optimal sleeping hours are 6am - 2pm.... I AM FINDING THIS INTERESTING BECAUSE I KNOW my LH & FSH is at the bottom of the scale (<1). So when boosted by the HCG, we can see the effect of the body's levels of LH & FSH. Does anyone else here find it amazing that levels that low can take testicles from full to SWOLLEN???!!!! I can rule out any injection delivery problems as the 5000ius was dispersed in (2) fatty sub-qs and (1) IM injection of equal proportion. The IM injection was last in the series of (3) injections all 3 days apart. There was not effect or testicular response until 12 hours after the last injection... Then the 3-4 days of cyclical swelling ensued, normalizing by day 5 with no extraordinary response notable. Go figure.....
As I mentioned before. I only go above 500ius and use that 5000iu protocol every 3-4 months as I build up that need to "feel alive" and be sure they still have life. Probably not the best idea, but I like to shake things up....
Yes I am worried about pituitary downregulation and I am wondering if there is any evidence that long term low dose usage will cause irreparable damage??
My regimen is spontaneous to say the least as I am an "enthusiast", in that I like to find the limits so that I will know what I am working with.. I usually hold a TRT regimen 10-16 weeks tops and then get antsy for a while.
I personally believe that the scope and depth of the effects of amphetamines on the HPTA are incredibly underrated!! The most amazing thing about amphetamines is that it is not that difficult to become immuned to them. And I have realized that what this means is that I have maxed my body's capabiility, and then ceased my body's capability, to respond to them. My adrenals are SMOKE. I am certain that parts of my body are now broken due to amphetamine use, as this would be the only way to explain how effects are now so minimized, even at doses that would send three people to the hospital!!!
I am currently taking stock. The fiddler is on standby and he brought the whole band, all with their hands out....
Quote:
Originally Posted by zkt
The pituitary releases LH and FSH in pulses very similar to the release of ACTH but at several times thurout the day. It would appear that you are timing the hcg to act in sync with pituitary. It also appears that you are using too much hcg. Pretty sure problem will go away if you stop hcg. The half life of hcg is ~30 hrs: you dont need to do it every day. The standard guideline is more like 500iu at the end of the T IM cycle, on day 6 for instance and take it from there is needed.
But 400 mg TC/w and 2500iu/ed ? You might as well do AS. You will drive you E thru the roof, down regulate the LH receptors, atrophy the LH and FSH secreting cells in the anterior pituitary (shut down the HPT axis) eventually. How long you been on this regimin?
Yea the amphetamins throws everything into high gear.
Ya might wanna take stock of the situation and consider some serious readjustment of the drugs.
Daily Fluctuations in HCG Response Normal?? 
But what about night time rants?? Oh yea, alchohol.
Linear Mode
