DHT as an anti Estrogen

[1cc]

Anti-Estrogen Effects Of DHT

One important function of DHT in the body that does not get much discussion is its antagonism of estrogen. Some men that take Proscar learn this the hard way—by developing a case of gynecomastia. By reducing DHT's protection against estrogen in the body, these men have fallen victim to its most dreaded ramification-bitch tits.

How does DHT protect against estrogen? There are at least three ways that this likely occurs. First of all, DHT directly inhibits estrogens activity on tissues. It either does this by acting as a competitive antagonist to the estrogen receptor or by decreasing estrogen-induced RNA transcription at a point subsequent to estrogen receptor binding.

Second of all, DHT and its metabolites have been shown to directly block the production of estrogens from androgens by inhibiting the activity of the aromatase enzyme. The studies done in breast tissue showed that DHT, androsterone, and 5alpha-androstandione are potent inhibitors of the formation of estrone from androstenedione. 5alpha-androstandione was shown to be the most potent, while androsterone was the least.

Lastly, DHT acts on the hypothalamus/pituitary to decrease the secretion of gonadotropins. By decreasing the secretion of gonadotropins you decrease the production of the raw materials for estrogen production testosterone and androstenedione (DHT itself cannot aromatize into estrogens). This property of DHT comes into particular utility when it is administered exogenously, and this is to be discussed in further detail in the next section.


Web link: http://www.bodybuilding.com/fun/reform8.htm

Does anyone have any more information about this?

[SPE]

To kinda go along with this, if DHT is elevated more so on Androgel than on Test injections, why is E2 also higher? I'd think the DHT would lower it?

[pmgamer18]

I had very high DHT levels and high E2 levels to anser this it is all about what your taking for TRT and how much. I was doing 10 grams of Testim and getting a 200 mg. Depo T shot evey other week. To much T means to high an E2 level.
Phil

[1cc]

swale,

Have you ever used DHT as an anti-estrogen or have you ever thought of using it in this way.

[SWALE]

Transdermals can elevate estrogens through direct conversion within the tissue underneath the application site.

IMPO, DHT has no place in TRT medicine.

[DavidZ]

Originally Posted by SWALE

IMPO, DHT has no place in TRT medicine.

Why not?

[HeadDoc]

BPH and hair loss in males who have virilized during adolesence. This not to say that DHT alone has not been used for trt. It's the risk of the former that would be most problematic. Futher, I don't think that there is any research to indicate that DHT alone produces the range of health benefits that testosterone replacement accomplishes, even with the increase in DHT that trt will bring with it.

[SWALE]

Right. Plus it induces the formation of intra-abdominal fat--increasing the risk of cardiovascular disease.

DHT also short-circuits the feedback mechanisms I rely upon to induce the most natural relationship between hormones possible under TRT.

[DavidZ]

Originally Posted by HeadDoc

BPH and hair loss in males who have virilized during adolesence. This not to say that DHT alone has not been used for trt. It's the risk of the former that would be most problematic. Futher, I don't think that there is any research to indicate that DHT alone produces the range of health benefits that testosterone replacement accomplishes, even with the increase in DHT that trt will bring with it.

I agree that DHT alone is not an appropriate form of TRT. But that wasn't the question.

The original contention was that "DHT has no place in TRT medicine." That was the premise I questioned.

Further, although the predominant view about benign prostatic hyperplasia or BPH is that it is due to a buildup of DHT, this hypothesis is far from proven. Much of what I've read (and experienced) indicates that elevated E2 and decreased T/E2 ratio (rather than elevated DHT) cause BPH and perhaps even prostate cancer.

[SWALE]

Yes, DHT and BPH are only loosely associaed. Fir if you have BPH, and I give ypou DHT, your prostate gets better, not worse. Estrogen is the true culprit in prostate morbidity.

I'm not going to delve into semantics. Were DHT of any use in TRT, I would be prescribing it.