Men's Health Forum: This is a discussion on GABA deficiencies and hypopituitary within the Anabolic Steroids forums, part of the extensive steroid information at MESO-Rx; Could there be a relation between the 2?
TIA,
JH...
I don't know for sure, but this is something I've wondered about too. What causes me to think there might be some connection between the two is that my sex drive is very low (testo is too), and when I take Valerian it goes up. Unless Valerian has some DA activity that I'm not aware of. I wouldn't be surprised if GABA had some effect on the pituitary cause it can control the firing of DA and 5-HT neurons, but overall I know it's effect is that of a balancer of excitatory neurotransmitters. Also since neurotransmission, immune cytokines and hormones are tightly interlocked, it may very well have an effect.
I think Dr. Marianco is not here these times--he would provide a much better reply that I did.
I don't know for sure, but this is something I've wondered about too. What causes me to think there might be some connection between the two is that my sex drive is very low (testo is too), and when I take Valerian it goes up. Unless Valerian has some DA activity that I'm not aware of. I wouldn't be surprised if GABA had some effect on the pituitary cause it can control the firing of DA and 5-HT neurons, but overall I know it's effect is that of a balancer of excitatory neurotransmitters. Also since neurotransmission, immune cytokines and hormones are tightly interlocked, it may very well have an effect.
I think Dr. Marianco is not here these times--he would provide a much better reply that I did.
Yeah, I thought you might since we share so many symptoms.
I seem to have low pituitary function as well as low GABA. But I have a theory that the low pituitary function could be caused by low GABA, but it would be nice to have Dr. Marianco or another one to confirm that this could happen.
The Valerian is supposed to raise GABA activity, which reduces anxiety and I think thats why your sex drive increases. But maybe it could be that your pituitary releases more LH and thereby increases testosterone...
BTW. From your recent posts it seems like you and your doc are suspecting your pituitary are faulty. Be sure to mail me whatever you guys find out. And if you want me to look over your bloodtests just let me know.
The Valerian is supposed to raise GABA activity, which reduces anxiety and I think thats why your sex drive increases. But maybe it could be that your pituitary releases more LH and thereby increases testosterone...
BTW. From your recent posts it seems like you and your doc are suspecting your pituitary are faulty. Be sure to mail me whatever you guys find out. And if you want me to look over your bloodtests just let me know.JH
With regards to GABA possibly increasing LH, this is a tantative reasoning I've had too, as Valerian is not know as a libido booster, unless through reduction of anxiety like you said. I wonder if the effect of anxiety has been measured on LH ?
Yes, I want to keep you posted as to what me and my pcp find--however with the many things I have on my mind, I'm not sure this will happen.
I'm not sure but I think I know who you are, you may be in the address book, but I'm not sure--I know a few people by their real names, but have forgotten their nick on the board
In either case, would you send me a PM, then I'll provide you with my email addy then, so I can remember to let you know what develops at my end.
I don't know for sure, but this is something I've wondered about too. What causes me to think there might be some connection between the two is that my sex drive is very low (testo is too), and when I take Valerian it goes up. Unless Valerian has some DA activity that I'm not aware of. I wouldn't be surprised if GABA had some effect on the pituitary cause it can control the firing of DA and 5-HT neurons, but overall I know it's effect is that of a balancer of excitatory neurotransmitters. Also since neurotransmission, immune cytokines and hormones are tightly interlocked, it may very well have an effect.
I think Dr. Marianco is not here these times--he would provide a much better reply that I did.
Valerian has some 5-HTP properties as well.
Also DA acts as an excitatory somewhere and as an inhibitory elsewhere.
Excitatory are NE/Epinephrine,Glutamate,ACH IIRC.
I'm not sure but I think I know who you are, you may be in the address book, but I'm not sure--I know a few people by their real names, but have forgotten their nick on the board
In either case, would you send me a PM, then I'll provide you with my email addy then, so I can remember to let you know what develops at my end.
Cheers
Yeah, its hard to keep track of all those nicks and real names. Im Jimmy, and I have your email addy, but I have just been to bussy to write you lately.
Since you suspect pituitary problems, I would very much like to see the result of your synacten stim test, and also your atch(corticotropin) baseline before the stim. However from your saliva test, and your high DHEA scores, I doubt you suffer from hypopituitary. At least it dosnt seem like your HPA is affected...
You could suffer from hypothyroid, a TSH at 2.8 could mean trouble. Whats your Free T4 and Free T3?
Yeah, its hard to keep track of all those nicks and real names. Im Jimmy, and I have your email addy, but I have just been to bussy to write you lately.
Since you suspect pituitary problems, I would very much like to see the result of your synacten stim test, and also your atch(corticotropin) baseline before the stim. However from your saliva test, and your high DHEA scores, I doubt you suffer from hypopituitary. At least it dosnt seem like your HPA is affected...
You could suffer from hypothyroid, a TSH at 2.8 could mean trouble. Whats your Free T4 and Free T3?
JH
When I said I had a feeling I had you in my address book, I thought that you were Jimmy, but didn't want to use your real name on the board--some don't mind and others do--I for one don't mind people using my real name here.
I'll definately let you know about the Synacthen test results--I'm anxious to be run the test......Friday of this week. I'm kinda tired of getting blood draws and injections now though.
I got some things to finish here at work, but later on, I'll post my latest FT4 TSH labs in this thread.
When I said I had a feeling I had you in my address book, I thought that you were Jimmy, but didn't want to use your real name on the board--some don't mind and others do--I for one don't mind people using my real name here.
I'll definately let you know about the Synacthen test results--I'm anxious to be run the test......Friday of this week. I'm kinda tired of getting blood draws and injections now though.
I got some things to finish here at work, but later on, I'll post my latest FT4 TSH labs in this thread.
Later
Gaba defieincy result of lack of GAD enzyme due to hypothyroid,P5P defieincy, zinc defeincy. possible glutamine defeincyy but usually resulting in excessive glutamine to glutamate conversion in the brain activating NDMA exctirory receptors causing hyperativity in the brain and imbalances in the hypothalamus. Your gase pedal is down but you aint got no breaks and eventually you CRASH
Theanine is good because it crosses blood brain barrier but if you are serotonin defiency then it can also lower serotonin but studies are inconclusive
When I said I had a feeling I had you in my address book, I thought that you were Jimmy, but didn't want to use your real name on the board--some don't mind and others do--I for one don't mind people using my real name here.
I'll definately let you know about the Synacthen test results--I'm anxious to be run the test......Friday of this week. I'm kinda tired of getting blood draws and injections now though.
I got some things to finish here at work, but later on, I'll post my latest FT4 TSH labs in this thread.
GABA deficiencies and hypopituitary 
Re: GABA deficiencies and hypopituitary 
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