Men's Health Forum: This is a discussion on help for my CFS within the Anabolic Steroids forums, part of the extensive steroid information at MESO-Rx; Originally Posted by hardasnails1973
David,
over 50 % of the population has the gene for genetic polymorphism , but only ...
David,
over 50 % of the population has the gene for genetic polymorphism , but only 10-15% of that population ever havce it triggered. Triggering is usually from intesnse enviormental exposure such as mercury or a bad viral infections, hence the actually foundation for CFS. Stress induced usually from an unresolved issue from child hood that is just barried in side one self and thinking it will go away, but in really when cells are dividing that information is being transported in to the new cells and then over time you have metabolic stress that is just waitng to be triggered by one tramatic event (infection, divorce, ect) and then that is when the mutatuion is exposed. most of the time it comes in the form of the mthfrr gene which leads to undermethyarion of the liver and low sam-e lor gltuhione levels and hence the vicious cycle begins.. Resarch autism methylation and you will find about 80% of your answres to CFS problems in there. I think your copper levels are being stored in your brain and liver causing alot of your problems giving you an excess in tissue and deficeincy in the blood so you have both excess and deficeinct symptoms what makes it hard.. Look into wilson disease and symtoms and you will see a major correlation
Thank you so much for this great advises, what the best way to lower copper in the brain or liver ?
I go the web of Gary Gordon maybe you have a better web ?
YES IT's vicious cycle (virus, bacteries, genes, liver problem, bad methylation... increase pro-inflammatory cytokines that result of too oxidative stress...
"On the other hand, increased levels of T cell activation suggest a pro inflammatory state is present in CFS. Pro-inflammatory cytokines have recently been associated with fatigue and/or other fatiguing diseases such as multiple sclerosis and cholestatic liver diseases. They are also largely believed responsible for producing the symptoms one has when sick. Some studies have suggested tumor necrosis factor alpha (TNF-a) plays a role in CFS. The high levels of oxidative stress present in CFS could be the result of high pro-inflammatory cytokine activity.
Thus there is evidence for the existence of a pro or anti-inflammatory state in CFS. De Meirleir has stated that the immune system in CFS is both under and over activated. This paper does not resolve this issue but it is the first study - surprisingly given a long history of immune research in CFS - to assess whether or not CFS patients have a genetic predisposition towards pro-or anti-inflammatory cytokine activity."
An Autism - Chronic Fatigue Syndrome Connection? - Advances in the understanding of autism are continuing to occur at a rapid pace, and there continues to be more evidence found that autism and CFS have a lot in common, in my opinion. At the 4th International Meeting for Autism Research Boston in April 2005, David Amaral et al. reported finding a 20 percent higher number of B lymphocytes in children with autism, compared to normals. Judy Van de Water et al. reported lower levels of cytokines in children with autism compared to normals, after antigen provocation. I haven't been able to find out yet which cytokineswere obsered to be lower. Combined with earlier research on the immune system and autism, the work of Amaral et al. suggests a Th2 shift and a suppression of cell-mediated immunity in autism, as is frequently found in CFS.
Here are some of the other features that have been reported in the past to be found in autism, which are also found in CFS:
* Oxidative stress
* Toxicity and sensitivity to toxins, especially mercury
* Gastrointestinal problems, including dysbiosis, leaky gut, and problems with casein and gluten.
* Coagulation problems
* Sleep disorders
* HPA axis dysfunction
* Abnormalities in sulfur metabolism
Researchers at UCLA are homing in on gene mutations associated with autism. S. Jill James and colleagues have already reported on some single-nucleotide polymorphisms that are associated with problems in methylation and detox, involving sulfur metabolism.
Thank you so much for this great advises, what the best way to lower copper in the brain or liver ?
I go the web of Gary Gordon maybe you have a better web ?
Rebalance the liver pathway with zinc, NAC, TMG, sam-e, methyl b-12 (might need injection to overide the methione synthase defect), folonic acid. Before anything get a serum b-12/folate test and homocysteine or amino acid urine test to see if you are sulfur resistant and need molybdenum (serum uric acid good indicator of this)
I find some connection : n the case of the autism work of Dr. James and coworkers, they found that increasing the intake of vitamin B12 (methylcobalamin),folinic acid (the active form of folic acid) and trimethyglycine (also known as betaine) was effective in bringing the glutathione level up to normal in children with autism.
Rebalance the liver pathway with zinc, NAC, TMG, sam-e, methyl b-12 (might need injection to overide the methione synthase defect), folonic acid. Before anything get a serum b-12/folate test and homocysteine or amino acid urine test to see if you are sulfur resistant and need molybdenum (serum uric acid good indicator of this)
Great. Many doctor doesn't like sam because when you stop you have more problem for methylation. This doctor prefer TMG. For sam what the best dosage ? 400 is OK ?
Oral B 12 doesn't work in oral form ? Difficult to find in injectable, I live in europe. My serum B12 is not so good, it's too low.
My homocysteine is 8; My uric acid is 40
Do you have a paper on low copper serum with wilson's disease ?
I find some connection : n the case of the autism work of Dr. James and coworkers, they found that increasing the intake of vitamin B12 (methylcobalamin),folinic acid (the active form of folic acid) and trimethyglycine (also known as betaine) was effective in bringing the glutathione level up to normal in children with autism.
Bingo I have researched autism for over 3 years and very well adapt to it as well
another thing you might want to look into is
RBC fatty acid levels some autistic childer have imbalances in AA//EPA ratio which could cause excessive of oxidative stress as well as cell membranes to eventually go into atopsis. Examing the alterations in phospholipids of cell membrane and correcting them will increase the bodys ability to detoxify as well. People sometimes get on the fish oil kick and never test RBC ended up creating the opopsite decreasing AA and actuially inducing a prediabteic state due to adrenal and insulin deficiency.
Bingo I have researched autism for over 3 years and very well adapt to it as well
another thing you might want to look into is
RBC fatty acid levels some autistic childer have imbalances in AA//EPA ratio which could cause excessive of oxidative stress as well as cell membranes to eventually go into atopsis. Examing the alterations in phospholipids of cell membrane and correcting them will increase the bodys ability to detoxify as well. People sometimes get on the fish oil kick and never test RBC ended up creating the opopsite decreasing AA and actuially inducing a prediabteic state due to adrenal and insulin deficiency.
BINGO again. my AA is low, I take at this time more AA.
I don't understand the pathophysiology of inducing a prediabteic state due to adrenal and insulin deficiency
BINGO again. my AA is low, I take at this time more AA.
I don't understand the pathophysiology of inducing a prediabteic state due to adrenal and insulin deficiency
AA is needed to increase insulin production and more so then anything you this is an indicatioin that your cell membranes are beginning to break down and over the peroid of years your body was releasing AA it called you had excessive phospholipase a2 which trigger excessive release of AA from the cell membrane this is prevented by vitamin E and hence indication of excessive lipid periodication in the brain (elevated SOD)
AA is needed to increase insulin production and more so then anything you this is an indicatioin that your cell membranes are beginning to break down and over the peroid of years your body was releasing AA it called you had excessive phospholipase a2 which trigger excessive release of AA from the cell membrane this is prevented by vitamin E and hence indication of excessive lipid periodication in the brain (elevated SOD)
Re: help for my CFS 
Linear Mode
