Men's Health Forum: This is a discussion on help for my CFS within the Anabolic Steroids forums, part of the extensive steroid information at MESO-Rx; I have CFS since 7 year's, I feel better now with thyroid/adrenal/Testosterone replacement therapy.
But some days I feel very ...
I have CFS since 7 year's, I feel better now with thyroid/adrenal/Testosterone replacement therapy.
But some days I feel very very bad. Headache, night sweeting, cramp in the legs and brain fog.
When I have this I take more vitamins B, vit C, omega 3 and probiotics.
I think my headache come from high glutamate/NO connection.
I speak with a doctor about neurontin for this glutamate antagonist but when I take it the result is poor.
In fact, I change test gel from test injectable. When I take 200 mg of testosterone undecanoate injectable I feel bad for three or for day depiste normal testosterone level. My estradiol is 20 is not so much. Marianco said that high testosterone make people worse.
May be for some people injectable is to much depiste I think that I take small dose like 200 mg nebido every two week or enanthate 50 2 time a week
Thank for advises
In fact, I think to possibility : my liver is doesn't like anymore injectable (17 year's of hypoganadism with injectable) or the HIGH from testosterone make me sick because it lower so much my adrenal
I don't think the second one because I take the day I feel bad more hydrocortisone.
How are you LFT's? Any gilberts syndrome or high billirubin? What makes you say your liver isnt handling the test?
I would check your gut flora through a stool sample and heavy metal toxicity by doing a Hair Mineral Analysis. Also a food allergy panel blood test. If youve got CFS, theres somthing causing it. Obviously though, if youve already got a viral thing going on, then that would probably need to be treated first.
How are you LFT's? Any gilberts syndrome or high billirubin? What makes you say your liver isnt handling the test?
I would check your gut flora through a stool sample and heavy metal toxicity by doing a Hair Mineral Analysis. Also a food allergy panel blood test. If youve got CFS, theres somthing causing it. Obviously though, if youve already got a viral thing going on, then that would probably need to be treated first.
THank you for answer; I don't understand "I don't How are you LFT's?" I do some test about food allergies, gut flora, heavy metal and viral...
THank you for answer; I don't understand "I don't How are you LFT's?" I do some test about food allergies, gut flora, heavy metal and viral...
Check for hidden underlying infections(candida, parsite, bactterial)
also if you NO is high then your cortisol levels are low and could be in adrenal fatigue this can be checked with cortisol salvia test. What was your lastest thyroid, testtosterone blood test results. you may have elevated reverse t-3 which could be blocking the receptor sites at the cell levels. Hair, stool, would be first place to begin as previously mentioned next liver detoxification or organic acid testing to se where metabolic road blocks could be hidden from standard blood testing. I have an idea your liver pathways are altered and Liver detoxifcation test would show these imbalances (gluthione, conjugation, sulfur oxidation, glucorication, ect)
Check for hidden underlying infections(candida, parsite, bactterial)
also if you NO is high then your cortisol levels are low and could be in adrenal fatigue this can be checked with cortisol salvia test. What was your lastest thyroid, testtosterone blood test results. you may have elevated reverse t-3 which could be blocking the receptor sites at the cell levels. Hair, stool, would be first place to begin as previously mentioned next liver detoxification or organic acid testing to se where metabolic road blocks could be hidden from standard blood testing. I have an idea your liver pathways are altered and Liver detoxifcation test would show these imbalances (gluthione, conjugation, sulfur oxidation, glucorication, ect)
yes you are right, I have problem with my liver detoxication, I do some genetic test and I have some problems with some hepatic gene for detox.
I take for many year's test injectable for HRT and my doctor put me on test gel; I begin now inj test undecanoate but after one day I have a pain in my liver. May be I come back with gel.
I take for my liver TMG and immunocal (undenatured protein) to increase my glutathion level and some curcumin for my enzyme detox phase 2. I take 10 gr of vict C ascorbate for detox too
But with that my liver doesn't support anymore injectable. It's bad for me because depiste my liver pain I prefer injectable for body composition and mood.
yes you are right, I have problem with my liver detoxication, I do some genetic test and I have some problems with some hepatic gene for detox.
I take for many year's test injectable for HRT and my doctor put me on test gel; I begin now inj test undecanoate but after one day I have a pain in my liver. May be I come back with gel.
I take for my liver TMG and immunocal (undenatured protein) to increase my glutathion level and some curcumin for my enzyme detox phase 2. I take 10 gr of vict C ascorbate for detox too
But with that my liver doesn't support anymore injectable. It's bad for me because depiste my liver pain I prefer injectable for body composition and mood.
You probablyu hae a disurption in the mthfrr gene similar to that of an austistic child which means you are undermethylated and need methy b-12, and foloninc acid to override it. Get an amino acid urinalysis done and see where your highest at. you are probably pising out taurine like crazy incidating you have an over active CBS pathway as well as molydebum deficeincy as well as gluthione deficiency which is very common in CFS. Add some glycine, pantheinet, it will help open up liver pathway 2. you are probably lacking coenyzme q10, and coenzyme A as well.
You probablyu hae a disurption in the mthfrr gene similar to that of an austistic child which means you are undermethylated and need methy b-12, and foloninc acid to override it. Get an amino acid urinalysis done and see where your highest at. you are probably pising out taurine like crazy incidating you have an over active CBS pathway as well as molydebum deficeincy as well as gluthione deficiency which is very common in CFS. Add some glycine, pantheinet, it will help open up liver pathway 2. you are probably lacking coenyzme q10, and coenzyme A as well.
Are you senitive to sulfur foods at all?
I don't known what the symptom ? Yes my docor said that I need more B12 selenium and zinc. What the name of coenzyme A ?I have very high SOD in the brain. It's a good antixoxydant but some physician's said that it's not so good. BUT AT THIS TIME I HAVE NO EXPLICATION WHY MY BRAIN SOD IS HIGH; I don't take deprenyl.
Thank for your answer
I don't known what the symptom ? Yes my docor said that I need more B12 selenium and zinc. What the name of coenzyme A ?I have very high SOD in the brain. It's a good antixoxydant but some physician's said that it's not so good. BUT AT THIS TIME I HAVE NO EXPLICATION WHY MY BRAIN SOD IS HIGH; I don't take deprenyl.
Thank for your answer
SOD is composed of copper/ zinc /mangaese so has your dr looked into possible estrogen imbalance as well as copper imbalnces? Copper can cause excitory action in the brain and may explain your high SOD , actually answer is pretty easy you have excessive oxidative stress in the brain. Do you get slight sligh seizures or spacial memory lapses?
You also need more vitamin E to prevent oxidative stress in the brain ,. if your zinc is low your vitamin e is low and so coenyzme q 10 and these all protect you from estrogen nasty side effects and also depelted in excessive estrogen, Yoour estrogen levels may be fine but you just might not be able to detoxify it
You need more methyl b-12 not normal -12
copper can depelte selenium because it is essential to activate its enzyme..
zinc is antagonistic to copper
Check your serum copper, ceruoplasm, uric acid levels and that may shed more light on the subject.
Last edited by hardasnails1973; 02-23-2007 at 10:46 AM.
SOD is composed of copper/ zinc /mangaese so has your dr looked into possible estrogen imbalance as well as copper imbalnces? Copper can cause excitory action in the brain and may explain your high SOD , actually answer is pretty easy you have excessive oxidative stress in the brain. Do you get slight sligh seizures or spacial memory lapses?
You also need more vitamin E to prevent oxidative stress in the brain ,. if your zinc is low your vitamin e is low and so coenyzme q 10 and these all protect you from estrogen nasty side effects and also depelted in excessive estrogen, Yoour estrogen levels may be fine but you just might not be able to detoxify it
You need more methyl b-12 not normal -12
copper can depelte selenium because it is essential to activate its enzyme..
zinc is antagonistic to copper
Check your serum copper, ceruoplasm, uric acid levels and that may shed more light on the subject.
Ho men .YOU ARE GOOD. I've slight sligh seizures or spacial memory lapses. But My vit E is too high . I dont known for my CoQ10 but my zinc,selenium, and copper too is not optimum. Before I've high estradiol level 60 ng but at this time my estradiol is 20 ng with arimidex . I think it's a correct. I buy some methyl B12 and zinc too.
I think my problem come from my liver. I don't feel bad but at this week I feel tired and seek because I change my HRT from test gel to inj test undecanoate (low dose 200 mg).
Do you think that injectable can have a bad action in the liver ?
My liver genetic test is not so good to.
Regarding the question on detoxification, let
me make the following comments:
This was my statement:
A genetic predisposition for a reduced enzymatic capacity for exotoxin
detoxification and an increased capacity for procarcinogen activation was
detected in two of the investigated genetic loci (GSTM1, CYP1B1).
Prophylactic measures such as exposure prophylaxis, smoking abstinence,
and the supplementation of antioxidants are therefore recommended.
CYP1B1 is a gain of function mutation and thus, the enzyme is working at
an increased intensity. Therefore, activation of procarcinogens is also
increased. The consequence is - in my opinion - that exposure to
procarcinogens should be minimized.
Secondly, detoxification due to the null mutation in GSTM1 is limited.
I think that nutritional interventions and antioxidants can be
recommended. Grapefruit consummation targeted at CYP1B1 is a good idea.
Another intervention might be the use of broccoli. This intervention,
however, has been clinically tested. It has been shown, that in only works
in individuals with a functional GSTM. For example, a diet rich in
cruciferous vegetables such as broccoli is sufficient to significantly
reduce the risk of lung cancer in the presence of a functional
glutathione-S-transferase M1 (GSTM1). This has been demonstrated in a
series of 1655 Caucasians (Wang et al. 2004). In addition, a diet rich in
cruciferous vergetables also significantly reduces the risk of prostate
cancer in men with a functional GSTM1 enzyme (Joseph et al. 2004).
THANK YOU GUY ON THIS BOARD because I KNOWN A LOT FROM YOU
Ho men .YOU ARE GOOD. I've slight sligh seizures or spacial memory lapses. But My vit E is too high . I dont known for my CoQ10 but my zinc,selenium, and copper too is not optimum. Before I've high estradiol level 60 ng but at this time my estradiol is 20 ng with arimidex . I think it's a correct. I buy some methyl B12 and zinc too.
I think my problem come from my liver. I don't feel bad but at this week I feel tired and seek because I change my HRT from test gel to inj test undecanoate (low dose 200 mg).
Do you think that injectable can have a bad action in the liver ?
My liver genetic test is not so good to.
Regarding the question on detoxification, let
me make the following comments:
This was my statement:
A genetic predisposition for a reduced enzymatic capacity for exotoxin
detoxification and an increased capacity for procarcinogen activation was
detected in two of the investigated genetic loci (GSTM1, CYP1B1).
Prophylactic measures such as exposure prophylaxis, smoking abstinence,
and the supplementation of antioxidants are therefore recommended.
CYP1B1 is a gain of function mutation and thus, the enzyme is working at
an increased intensity. Therefore, activation of procarcinogens is also
increased. The consequence is - in my opinion - that exposure to
procarcinogens should be minimized.
Secondly, detoxification due to the null mutation in GSTM1 is limited.
I think that nutritional interventions and antioxidants can be
recommended. Grapefruit consummation targeted at CYP1B1 is a good idea.
Another intervention might be the use of broccoli. This intervention,
however, has been clinically tested. It has been shown, that in only works
in individuals with a functional GSTM. For example, a diet rich in
cruciferous vegetables such as broccoli is sufficient to significantly
reduce the risk of lung cancer in the presence of a functional
glutathione-S-transferase M1 (GSTM1). This has been demonstrated in a
series of 1655 Caucasians (Wang et al. 2004). In addition, a diet rich in
cruciferous vergetables also significantly reduces the risk of prostate
cancer in men with a functional GSTM1 enzyme (Joseph et al. 2004).
THANK YOU GUY ON THIS BOARD because I KNOWN A LOT FROM YOU
_________________________________________
G
David,
over 50 % of the population has the gene for genetic polymorphism , but only 10-15% of that population ever havce it triggered. Triggering is usually from intesnse enviormental exposure such as mercury or a bad viral infections, hence the actually foundation for CFS. Stress induced usually from an unresolved issue from child hood that is just barried in side one self and thinking it will go away, but in really when cells are dividing that information is being transported in to the new cells and then over time you have metabolic stress that is just waitng to be triggered by one tramatic event (infection, divorce, ect) and then that is when the mutatuion is exposed. most of the time it comes in the form of the mthfrr gene which leads to undermethyarion of the liver and low sam-e lor gltuhione levels and hence the vicious cycle begins.. Resarch autism methylation and you will find about 80% of your answres to CFS problems in there. I think your copper levels are being stored in your brain and liver causing alot of your problems giving you an excess in tissue and deficeincy in the blood so you have both excess and deficeinct symptoms what makes it hard.. Look into wilson disease and symtoms and you will see a major correlation
help for my CFS 
Linear Mode
