Unless a person has a deficiency of IGF-1 (not a low normal value), or a positive
test on GHRH-Arginine
Test, and unless treatment is monitored and treatment adjusted, there are significant risks to Growth Hormone treatment.
Growth Hormone has significant adverse effects which need monitoring, including:
1. It can increase insulin resistance
2. It can reduce thyroid hormone activity
3. It can reduce adrenal cortex activity - essentially causing adrenal fatigue or insufficiency
These changes can themselves cause a chain-reaction and changes in other parts of the neuroendocrine system - e.g. lower testosterone levels and other neurotransmitter and hormone changes.
Other adverse effects include fluid retention, pins-and-needles and other sensory changes, joint stiffness, muscle pains, carpal tunnel syndrome, edema, impaired eyesight (retinopathy), accelerating tumor growth, etc.
Symptoms of excess growth hormone can include anxiety, insomnia, depressed mood, loss of libido, lack of energy, mental clouding, weight gain, hypertension, heart disease, stroke, osteoporosis, etc. These are opposite of what one hopes to obtain from treatment.
It is thus important to have more extensive monitoring and adjustment of the neuroendocrine system, and growth hormone treatment be adjusted (i.e. lowered) when adverse effects occur.
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Originally Posted by bullmastiff I noticed since starting hgh my mood has been brighter. Seems to have a stimulating effect on my moods. However once I reached 1.5 iu a day i seemed to have reached a point where I feel nervous from the effect. I did a 2 iu shot yesterday and felt really jittery and had a hard time sleeping. Has anyone noticed this mental effect from hgh? |