Even though there is no mention of E2 in the article.
NEW YORK (Reuters Health) - Overweight middle-aged adults tend to score more poorly on tests of memory, attention and learning ability than their thinner peers do, researchers reported Monday.
The findings, they say, suggest that a heavier weight in middle age may mean a higher risk of dementia later in life.
Reporting in the journal Neurology, the researchers speculate that higher rates of cardiovascular disease or diabetes might help explain the link. But it's also possible that substances produced by fat cells, such as the hormone leptin, have direct effects on the brain.
Both obesity and dementia, including
Alzheimer's disease, are becoming increasingly common, noted lead study author Dr. Maxime Cournot, of Toulouse University Hospital in France.
http://news.yahoo.com/s/nm/20061009/...ight_mental_dc 
10-10-2006, 05:55 PM
I'm willing to bet E2 plays a role in this (article on obesity and mental function) 
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