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Men's Health Forum: This is a discussion on Might epitestosterone be the reason that exogenous testosterone seems better? within the Anabolic Steroids forums, part of the extensive steroid information at MESO-Rx; http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Citation This is old news, but I hadn't done any research on epitestosterone in the past, so it is new ...

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Old 08-25-2005, 02:44 PM
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Default Might epitestosterone be the reason that exogenous testosterone seems better?

http://www.ncbi.nlm.nih.gov/entrez/q...&dopt=Citation

This is old news, but I hadn't done any research on epitestosterone in the past, so it is new to me:

Epitestosterone has been identified as a natural component of biological fluids of several mammals including man. For a long time it was believed that it is a metabolite without any hormonal activity and without any marked relationship to the hormonal state in health and disease. Neither the biosynthetic pathway nor the site of its formation in man have been unequivocally confirmed to date. It apparently parallels the formation of testosterone (T), but on the other hand its concentration is not influenced by exogenous administration of testosterone. This fact creates the basis of the present doping control of testosterone abuse. In 1989 an observation was presented in a dermatological study that epitestosterone exerts an effect counteracting the action of testosterone on flank organ of Syrian hamster. Further studies showed that a complex action consisting of competitive binding of epitestosterone to androgen receptor, of inhibition of testosterone biosynthesis and its reduction to dihydrotestosterone and of antigonadotropic activity could be demonstrated in rat, mice and human tissues. It can be presumed that epitestosterone as a natural hormone can contribute to the regulation of such androgen dependent events as, e.g. the control of prostate growth or body hair distribution.
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Old 08-27-2005, 06:37 PM
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So then in theory one could expereince symptoms of hypogonadism without having low levels of testosterone? Why is epitestosterone not measured?
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Old 08-29-2005, 05:46 AM
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It's news to me as well.
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