Men's Health Forum: This is a discussion on Pregnenolone within the Anabolic Steroids forums, part of the extensive steroid information at MESO-Rx; Originally Posted by pmgamer18
There is some talk about Pregnenolone in this link.
http://www.totalityofbeing.com/Archi...eofaPenis.html
I said Dr. Low I ment ...
Looks like correcting hypothyroid should correct low pregnenolone.
Serum dehydroepiandrosterone, dehydroepiandrosterone sulfate, and pregnenolone sulfate concentrations in patients with hyperthyroidism and hypothyroidism.
Tagawa N, Tamanaka J, Fujinami A, et al.
Clin Chem. 2000 Apr; 46(4):523-8.
BACKGROUND: Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) have been suggested to have protective effects against cardiovascular disease, cancer, immune-modulated diseases, and aging. We examined serum concentrations of DHEA, DHEA-S, and pregnenolone sulfate (PREG-S) in patients with thyroid dysfunction. METHODS: Steroids extracted with methanol from serum sample were separated into an unconjugated fraction (DHEA) and a monosulfate fraction (DHEA-S and PREG-S), using a solid-phase extraction and an ion-exchange column. After separation of unconjugated steroids by HPLC, the DHEA concentration was measured by enzyme immunoassay. The monosulfate fraction was treated with arylsulfatase, and the freed steroids were separated by HPLC. The DHEA and PREG fractions were determined by gas chromatography-mass spectrometry, and the concentrations were converted into those of DHEA-S and PREG-S. RESULTS: Serum concentrations of DHEA, DHEA-S, and PREG-S were all significantly lower in patients with hypothyroidism (n = 24) than in age- and sex-matched healthy controls (n = 43). By contrast, in patients with hyperthyroidism (n = 22), serum DHEA-S and PREG-S concentrations were significantly higher, but the serum DHEA concentration was within the reference interval. Serum concentrations of these three steroids correlated with serum concentrations of thyroid hormones in these patients. Serum albumin and sex hormone-binding globulin concentrations were not related to these changes in the concentration of steroids. CONCLUSIONS: Serum concentrations of DHEA, DHEA-S, and PREG-S were decreased in hypothyroidism, whereas serum DHEA-S and PREG-S concentrations were increased but DHEA was normal in hyperthyroidism. Thyroid hormone may stimulate the synthesis of these steroids, and DHEA sulfotransferase might be increased in hyperthyroidism
Looks like correcting hypothyroid should correct low pregnenolone.
Serum dehydroepiandrosterone, dehydroepiandrosterone sulfate, and pregnenolone sulfate concentrations in patients with hyperthyroidism and hypothyroidism.
Tagawa N, Tamanaka J, Fujinami A, et al.
Clin Chem. 2000 Apr; 46(4):523-8.
BACKGROUND: Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) have been suggested to have protective effects against cardiovascular disease, cancer, immune-modulated diseases, and aging. We examined serum concentrations of DHEA, DHEA-S, and pregnenolone sulfate (PREG-S) in patients with thyroid dysfunction. METHODS: Steroids extracted with methanol from serum sample were separated into an unconjugated fraction (DHEA) and a monosulfate fraction (DHEA-S and PREG-S), using a solid-phase extraction and an ion-exchange column. After separation of unconjugated steroids by HPLC, the DHEA concentration was measured by enzyme immunoassay. The monosulfate fraction was treated with arylsulfatase, and the freed steroids were separated by HPLC. The DHEA and PREG fractions were determined by gas chromatography-mass spectrometry, and the concentrations were converted into those of DHEA-S and PREG-S. RESULTS: Serum concentrations of DHEA, DHEA-S, and PREG-S were all significantly lower in patients with hypothyroidism (n = 24) than in age- and sex-matched healthy controls (n = 43). By contrast, in patients with hyperthyroidism (n = 22), serum DHEA-S and PREG-S concentrations were significantly higher, but the serum DHEA concentration was within the reference interval. Serum concentrations of these three steroids correlated with serum concentrations of thyroid hormones in these patients. Serum albumin and sex hormone-binding globulin concentrations were not related to these changes in the concentration of steroids. CONCLUSIONS: Serum concentrations of DHEA, DHEA-S, and PREG-S were decreased in hypothyroidism, whereas serum DHEA-S and PREG-S concentrations were increased but DHEA was normal in hyperthyroidism. Thyroid hormone may stimulate the synthesis of these steroids, and DHEA sulfotransferase might be increased in hyperthyroidism
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Yes interesting read, but Im sure Dr John was against using progesterone in men full stop?
This Dr Wong seems to think that supplementing with Pregnenolone will convert mostly to estrogen... he also fails to mention that some estrogen is very important to males.
Yes interesting read, but Im sure Dr John was against using progesterone in men full stop?
This Dr Wong seems to think that supplementing with Pregnenolone will convert mostly to estrogen... he also fails to mention that some estrogen is very important to males.
I take 50 mg of Pregnenolone and as you can see in my signature below, my E2 is fine, even with my TT level being over 800.
I consulted with Dr. David Brownstein (very bright, cutting edge fellow) and he recommended that I take 25mg of Pregnenolone and 10mg of DHEA. I already had a bottle of 50mg caps of preg, so that is what I took, and since DHEA comes in 25mg tabs that are scored, I break them in half for 12.5mg per day which is close enough. He felt many people take doses of DHEA that are to high. I personally have observed that when I have taken just 25mg per day in the past, I broke out with acne, so that was indeed to much for me.
I think these hormones have played a large part in me recovering from Adrenal Fatigue.
I take 50 mg of Pregnenolone and as you can see in my signature below, my E2 is fine, even with my TT level being over 800.
Do you feel that the pregnenolone wears off too quick because it's oral. The benefit of transdermal is that it releases over 24 hours, which I don't know if it's better that way or not. Do you have any info on transdermal pregnenolone? Most of the literature I've read talks about oral and not transdermal.
Do you feel that the pregnenolone wears off too quick because it's oral. The benefit of transdermal is that it releases over 24 hours, which I don't know if it's better that way or not. Do you have any info on transdermal pregnenolone? Most of the literature I've read talks about oral and not transdermal.
I don't have any info on transdermal. I just look at it in the same way as I do DHEA, oral seems to get the job done, and it is pretty darn cheap, and that is what Dr. Brownstein uses. I have not had labs however to identify what my levels are.
Here's a few major points, I've taken from the Hormone Book by T Hertoghe. Prinicipal hormones derived from pregnenole include: androgens, progesterones, glucocorticoids, and mineral corticoids. Pregnenolne functions a neurotranmitter in the nervous system particularly in the area of the brain responsible for memory. 50 mg. seems to be the baseline dose for memory effects--it can take a month or more( 3 to 4) of dosing to achieve an adequate memory improvement. It is also useful for anti-rheumatic effects. Normal daily decretions of pregnenolone has not been documented in the literature. Decline of it as a part of agining also parallels the decline of toher hormones. Blood testing is usually done in the AM. 90-100 ng/ml is optimal, 0-70 if probably deficient, reference range 40- 120. The author had no information on the transdermal. Sublingual dose is 5-40 mg per day and oral dose is 10-50 mg per day.
1CC, sorry it took so long to get on this. Pat
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Re: Pregnenolone 
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