Men's Health Forum: This is a discussion on Pregnenolone within the Anabolic Steroids forums, part of the extensive steroid information at MESO-Rx; Rob,
What was the result of your experiment? Were you able to completely refrain from exo Cortisol, and replace your ...
Rob,
What was the result of your experiment? Were you able to completely refrain from exo Cortisol, and replace your endo cortisol level naturally with PREG ?
Quote:
Originally Posted by raw1973
This is what I'm hoping for. I started taking Preg. 20mg and DHEA 25 mg as I weaned off HC.
I'm hoping that the Pregn. will convert into any defficient cortisol because I have the DHEA supplemented already. My libido seems better also.( it had dropped as I dropped HC)
This is the 3rd day off HC and I'm feeling much better than the last time I tried to come off and got shaky,dizzy and had to go back on for a couple weeks. Not sure if it's the supplements but I will continue for a month or so, till natural levels come up. --Rob
Do a test for pregnanediol. It is a metabolite of progesterone that can be tested via bloodtest, and the result can generally be trusted with more confidence vs. the PREG assay. Usually, you can indirectly test for PREG when you do an pregnanediol assay, because if pregnanediol assay returns as high, so too is your PREG high, or in the acceptable range.
Quote:
Originally Posted by clloyd
I know this is an old thread, and I have seen older threads about the benefits of TD Pregnenolone over oral. However, I couldn't tell the difference. I had above average pregnenoone levels before starting TRT and now my pregnenolone assay is below the reference range while using TD pregnenolone. Is the assay worth anything? Should I be concerned? Someone once told me the preg assay is worthless because preg gets converted down the chain so quickly that it doesn't sit as preg too long...anyone?
I use 50mg of pregnenolone daily. It helps with a lot of my chronic fatigue syndrome symptoms; hypoglycemia, joint pain, alcohol intolerance, allergies. It's a wonder drug for somethings but I think I may be taking too high a dose.
On my next order I'm going to grab some 25mg instead. Side effects like bloating and acne regularly occur.
john crisler would attribute the bloating from PREG do to improper adminstration of the incorrect form of the hormone...Chrisler says that TD PREG never causes elevated PROG/e2 levels, but when taken orally, has a penchant for doing so. He recommends 50mg TD PREG ED.
Quote:
Originally Posted by Dopamineloveaffair
I use 50mg of pregnenolone daily. It helps with a lot of my chronic fatigue syndrome symptoms; hypoglycemia, joint pain, alcohol intolerance, allergies. It's a wonder drug for somethings but I think I may be taking too high a dose.
On my next order I'm going to grab some 25mg instead. Side effects like bloating and acne regularly occur.
1cc,
Are you saying that you were able to complete go off HC when you began using PREG, because in your case, PREG was able to increase your cortisol production?
It did seem to be so at the time. I did, however, much later restart using HC because of additional work demands. I have since stopped using pregnenolone, because my DHEA sulfate came back over the top if the range. This was while concurrently taking 25mg DHEA every day with 10mg oral pregnenolone.
Is this adrenal fatigue or suppression of your HPA axis?? You produce 24nM of Cortisol/day that is like a bit lower than the half the actual amount and the starting point of your HPA(AM cortisol) is borderline low.if tests are done properly. But do you have high plasma noradrenaline levels?? Have you checked for ACTH values??
How long did you have this problem for and what is the reason?? How did it start?? Drug abuse/exercise/ physical or mental stress or what?? Viral infection maybe??
Is this adrenal fatigue or suppression of your HPA axis?? You produce 24nM of Cortisol/day that is like a bit lower than the half the actual amount and the starting point of your HPA(AM cortisol) is borderline low.if tests are done properly. But do you have high plasma noradrenaline levels?? Have you checked for ACTH values??
How long did you have this problem for and what is the reason?? How did it start?? Drug abuse/exercise/ physical or mental stress or what?? Viral infection maybe??
Your thyroid is running low which is putting stress on your adrenals..Fix the thyroid and support adrenals then you should feel better. SAlivary is useless for male sex hormones Support with licorace root specific one from metagenics.
__________________
Please keep in mind that this answer is for information purposes only,
and is not intended to diagnose, treat or replace sound medical advice
from your physician or health care provider.
are you taking TD PREG or oral PREG or neither? Some report a PREG TD induced increase in cortisol when they use TD PREG at +/- 50-100mg ED. I have read reports on people who while on HRT and HC, their anxiety goes through the roof as soon as they dump in TD PREG because they feel that it is all going down the mineralcorticoid, and glucocorticoid route.
Quote:
Originally Posted by s0b
My DHEA seems to be fine. Just the cortisol that is low. Of course sex hormones are out of whack but you can't rely on a salival panel for that.
Is this adrenal fatigue or suppression of your HPA axis?? You produce 24nM of Cortisol/day that is like a bit lower than the half the actual amount and the starting point of your HPA(AM cortisol) is borderline low.if tests are done properly. But do you have high plasma noradrenaline levels?? Have you checked for ACTH values??
How long did you have this problem for and what is the reason?? How did it start?? Drug abuse/exercise/ physical or mental stress or what?? Viral infection maybe??
How about this....
High Pregnenolone and its sulfate CAUSE hyperthyroidism...not the other way around. Check out Ray Sahelian's blog/semi formal forum...He cites PREG induced hyperthyroidism based off of reports that when people who might not initially have hyperthyroidism consume PREG, they have actually developed hyperthyroidism...
Quote:
Originally Posted by 1cc
Looks like correcting hypothyroid should correct low pregnenolone.
Serum dehydroepiandrosterone, dehydroepiandrosterone sulfate, and pregnenolone sulfate concentrations in patients with hyperthyroidism and hypothyroidism.
Tagawa N, Tamanaka J, Fujinami A, et al.
Clin Chem. 2000 Apr; 46(4):523-8.
BACKGROUND: Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) have been suggested to have protective effects against cardiovascular disease, cancer, immune-modulated diseases, and aging. We examined serum concentrations of DHEA, DHEA-S, and pregnenolone sulfate (PREG-S) in patients with thyroid dysfunction. METHODS: Steroids extracted with methanol from serum sample were separated into an unconjugated fraction (DHEA) and a monosulfate fraction (DHEA-S and PREG-S), using a solid-phase extraction and an ion-exchange column. After separation of unconjugated steroids by HPLC, the DHEA concentration was measured by enzyme immunoassay. The monosulfate fraction was treated with arylsulfatase, and the freed steroids were separated by HPLC. The DHEA and PREG fractions were determined by gas chromatography-mass spectrometry, and the concentrations were converted into those of DHEA-S and PREG-S. RESULTS: Serum concentrations of DHEA, DHEA-S, and PREG-S were all significantly lower in patients with hypothyroidism (n = 24) than in age- and sex-matched healthy controls (n = 43). By contrast, in patients with hyperthyroidism (n = 22), serum DHEA-S and PREG-S concentrations were significantly higher, but the serum DHEA concentration was within the reference interval. Serum concentrations of these three steroids correlated with serum concentrations of thyroid hormones in these patients. Serum albumin and sex hormone-binding globulin concentrations were not related to these changes in the concentration of steroids. CONCLUSIONS: Serum concentrations of DHEA, DHEA-S, and PREG-S were decreased in hypothyroidism, whereas serum DHEA-S and PREG-S concentrations were increased but DHEA was normal in hyperthyroidism. Thyroid hormone may stimulate the synthesis of these steroids, and DHEA sulfotransferase might be increased in hyperthyroidism
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