Pregnenolone

[1cc]

For the past 2 days I have tried 10mg of oral pregnenolone in the morning. The results have been really, really good. I have Adrenal Fatigue and take 5mg hydrocortisone in the morning and 25mg DHEA. I was pondering at one time whether it would be better to take pregnenolone which converts into all the Adrenal hormones (Cortisol, DHEA, Aldosterone, Progesterone, Testosterone, Estrogen), or to take the hormones individually because one does not know what pregnenolone is going to convert to, and one relies on the body's wisdom to convert pregnenolone to what it needs. Taking the pregnenolone the past couple days is making me think that it is the better route. I have experienced an even better "feeling of well being" than from using HCG.

Most of the literature discusses the use of oral pregnenolone. There is also no info about how long a single dose will be effective for. I noticed that pregnenolone is also available in a cream which delivers 15mg of pregnenolone, which I believe would be equal to about a 50mg oral dose, which I think may be too much.

Does anyone have any info on oral versus transdermal?

[1cc]

http://www.vitaminusa.com/prbocr2ozbyl.html

[Naturdoc]

You might also consider sublingual drops as a more efficient delivery method.
You can titrate the topical cream dose by how you feel. - Use a1/4 tsp instead of a full pump etc.
The "essential oils" in this product could be problematic if they are lavender or tea tree, both possibly estrogenic.
10-20 mg is a good starting dose orally and give it a week or two to equilibrate in your system.

[pmgamer18]

Originally Posted by 1cc

For the past 2 days I have tried 10mg of oral pregnenolone in the morning. The results have been really, really good. I have Adrenal Fatigue and take 5mg hydrocortisone in the morning and 25mg DHEA. I was pondering at one time whether it would be better to take pregnenolone which converts into all the Adrenal hormones (Cortisol, DHEA, Aldosterone, Progesterone, Testosterone, Estrogen), or to take the hormones individually because one does not know what pregnenolone is going to convert to, and one relies on the body's wisdom to convert pregnenolone to what it needs. Taking the pregnenolone the past couple days is making me think that it is the better route. I have experienced an even better "feeling of well being" than from using HCG.

Most of the literature discusses the use of oral pregnenolone. There is also no info about how long a single dose will be effective for. I noticed that pregnenolone is also available in a cream which delivers 15mg of pregnenolone, which I believe would be equal to about a 50mg oral dose, which I think may be too much.

Does anyone have any info on oral versus transdermal?

I could sware Dr. John said he has all his men on this now. I was going to try it but felt doing Isocort and HCG it would turn to E2. There is time release form of it.
http://search.store.yahoo.com/cgi-bi...lone+&x=21&y=8

[pmgamer18]

Originally Posted by pmgamer18

I could sware Dr. John said he has all his men on this now. I was going to try it but felt doing Isocort and HCG it would turn to E2. There is time release form of it.
http://search.store.yahoo.com/cgi-bi...lone+&x=21&y=8

Here is a cut and paste on what Dr. John said.
I quit running pregnenolone assays--they are ALWAYS low. Dr. Rothenberg made this same comment in one of his lectures.

I use a trandermal cream whihc Signature compounds for us.

I now want all of my guys on TRT to take it, along with DHEA, to help rebalance the pathways.

Pregenenolone is lowered in TRT because the P450scc enzyme (which converts CHOL into pregnenolone) is reduced in activity by lowered gonadotropins, as it is by ACTH. This is also why I always use HCG in every TRT patient.

[1cc]

Originally Posted by Naturdoc

10-20 mg is a good starting dose orally and give it a week or two to equilibrate in your system.

How long does the effect of pregnenolone last when taking a single morning oral dose? Is it necessary to take more than one dose per day in your experience? The cream has the effect of a prolonged release, although I'm not sure if this is necessary.

[1cc]

Originally Posted by pmgamer18

I could sware Dr. John said he has all his men on this now. I was going to try it but felt doing Isocort and HCG it would turn to E2. There is time release form of it.
http://search.store.yahoo.com/cgi-bi...lone+&x=21&y=8

I believe Dr. John has one of his patients take 60mg pregnenolone cream, which is a very high dose for a cream.

Some of what I have read has said that if you take pregnenolone and DHEA, one should reduce the DHEA by the amount of the added pregnenolone. So if one takes 50mg DHEA per day and decides to take 25mg pregnenolone, then the DHEA should be reduced to 25mg per day as well.

[pmgamer18]

Originally Posted by 1cc

I believe Dr. John has one of his patients take 60mg pregnenolone cream, which is a very high dose for a cream.

Some of what I have read has said that if you take pregnenolone and DHEA, one should reduce the DHEA by the amount of the added pregnenolone. So if one takes 50mg DHEA per day and decides to take 25mg pregnenolone, then the DHEA should be reduced to 25mg per day as well.

Good point I believer Dr. Low talks about this I am going to do some searching see what I can find.

[pmgamer18]

There is some talk about Pregnenolone in this link.
http://www.totalityofbeing.com/Archi...eofaPenis.html
I said Dr. Low I ment to say Dr. John Lee.

[pmgamer18]

This has a lot in it.
http://www.tidesoflife.com/pregprodhea.htm
From this seach.
http://www.google.com/search?hl=en&l...2BPregnenolone

[1cc]

Originally Posted by pmgamer18

There is some talk about Pregnenolone in this link.
http://www.totalityofbeing.com/Archi...eofaPenis.html
I said Dr. Low I ment to say Dr. John Lee.

Thanks Phil. Interesting link.

[JanSz]

Pregnenolone (50 mg daily dose)
is contained in Cognitex, one of the top ten supplements (#6)
Cognitex with Pregnenolone & NeuroProtection Complex

http://www.lef.org/newshop/top_products/

http://www.lef.org/newshop/items/item00822.html

[1cc]

Looks like correcting hypothyroid should correct low pregnenolone.

Serum dehydroepiandrosterone, dehydroepiandrosterone sulfate, and pregnenolone sulfate concentrations in patients with hyperthyroidism and hypothyroidism.

Tagawa N, Tamanaka J, Fujinami A, et al.

Clin Chem. 2000 Apr; 46(4):523-8.

BACKGROUND: Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) have been suggested to have protective effects against cardiovascular disease, cancer, immune-modulated diseases, and aging. We examined serum concentrations of DHEA, DHEA-S, and pregnenolone sulfate (PREG-S) in patients with thyroid dysfunction. METHODS: Steroids extracted with methanol from serum sample were separated into an unconjugated fraction (DHEA) and a monosulfate fraction (DHEA-S and PREG-S), using a solid-phase extraction and an ion-exchange column. After separation of unconjugated steroids by HPLC, the DHEA concentration was measured by enzyme immunoassay. The monosulfate fraction was treated with arylsulfatase, and the freed steroids were separated by HPLC. The DHEA and PREG fractions were determined by gas chromatography-mass spectrometry, and the concentrations were converted into those of DHEA-S and PREG-S. RESULTS: Serum concentrations of DHEA, DHEA-S, and PREG-S were all significantly lower in patients with hypothyroidism (n = 24) than in age- and sex-matched healthy controls (n = 43). By contrast, in patients with hyperthyroidism (n = 22), serum DHEA-S and PREG-S concentrations were significantly higher, but the serum DHEA concentration was within the reference interval. Serum concentrations of these three steroids correlated with serum concentrations of thyroid hormones in these patients. Serum albumin and sex hormone-binding globulin concentrations were not related to these changes in the concentration of steroids. CONCLUSIONS: Serum concentrations of DHEA, DHEA-S, and PREG-S were decreased in hypothyroidism, whereas serum DHEA-S and PREG-S concentrations were increased but DHEA was normal in hyperthyroidism. Thyroid hormone may stimulate the synthesis of these steroids, and DHEA sulfotransferase might be increased in hyperthyroidism

[pmgamer18]

Great find.

Originally Posted by 1cc

Looks like correcting hypothyroid should correct low pregnenolone.

Serum dehydroepiandrosterone, dehydroepiandrosterone sulfate, and pregnenolone sulfate concentrations in patients with hyperthyroidism and hypothyroidism.

Tagawa N, Tamanaka J, Fujinami A, et al.

Clin Chem. 2000 Apr; 46(4):523-8.

BACKGROUND: Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) have been suggested to have protective effects against cardiovascular disease, cancer, immune-modulated diseases, and aging. We examined serum concentrations of DHEA, DHEA-S, and pregnenolone sulfate (PREG-S) in patients with thyroid dysfunction. METHODS: Steroids extracted with methanol from serum sample were separated into an unconjugated fraction (DHEA) and a monosulfate fraction (DHEA-S and PREG-S), using a solid-phase extraction and an ion-exchange column. After separation of unconjugated steroids by HPLC, the DHEA concentration was measured by enzyme immunoassay. The monosulfate fraction was treated with arylsulfatase, and the freed steroids were separated by HPLC. The DHEA and PREG fractions were determined by gas chromatography-mass spectrometry, and the concentrations were converted into those of DHEA-S and PREG-S. RESULTS: Serum concentrations of DHEA, DHEA-S, and PREG-S were all significantly lower in patients with hypothyroidism (n = 24) than in age- and sex-matched healthy controls (n = 43). By contrast, in patients with hyperthyroidism (n = 22), serum DHEA-S and PREG-S concentrations were significantly higher, but the serum DHEA concentration was within the reference interval. Serum concentrations of these three steroids correlated with serum concentrations of thyroid hormones in these patients. Serum albumin and sex hormone-binding globulin concentrations were not related to these changes in the concentration of steroids. CONCLUSIONS: Serum concentrations of DHEA, DHEA-S, and PREG-S were decreased in hypothyroidism, whereas serum DHEA-S and PREG-S concentrations were increased but DHEA was normal in hyperthyroidism. Thyroid hormone may stimulate the synthesis of these steroids, and DHEA sulfotransferase might be increased in hyperthyroidism

[Matt Muscle]

Originally Posted by pmgamer18

There is some talk about Pregnenolone in this link.
http://www.totalityofbeing.com/Archi...eofaPenis.html
I said Dr. Low I ment to say Dr. John Lee.

Yes interesting read, but Im sure Dr John was against using progesterone in men full stop?
This Dr Wong seems to think that supplementing with Pregnenolone will convert mostly to estrogen... he also fails to mention that some estrogen is very important to males.