Progesterone to reduce estrogen with TRT

[HeadDoc]

Originally Posted by DuncanWA

Saw my doc yesterday. We're keeping the T cream at 100mg but we're separating it out from the rest of the cocktail due to some anecdotal evidence of T being hampered by the other ingredients. We're also cutting out the HCG completely in part due to skyrocketing DHT and E2.

New regimen is:
100mg of compounded T cream
25mg of progesterone and 10mg of DHEA compounded cream. Thinking is progesterone can inhibit DHT and some E2 formation.
50mcg (micrograms) of Arimidex daily for high E2. There are some reports of daily small amounts being very effective and my new pharm can compound the Arimidex.

We're also changing compounding pharms from one here in Spokane to a Calif outfit. My doc has had some patients that have had less than predicted results w/some of the elixirs coming from there. Full retest in 3 weeks.

Duncan you and your doc could be onto some new protocol or at least some major changes in the protocols that we are very familiar with. Please keep this post alive with followups. Or start a new thread. Additional information that might help is: diet and exercise, current weight, and of course labs.

[JanSz]

Originally Posted by DuncanWA

So you're saying preg cream could be an alternative to something like Arimidex?

I have top of the charts free T (154 on scale of 35-155 Quest), middle of the road total T (494 on scale of 250-1100), increasing DHT (96 scale of 25-75) and increasing E2 (41 scale of 13-54). Progesterone is .6 on scale of .1 - 1.2.

My treatment is 100mg of compounded T cream with 25mg preg and 5mg DHEA compounded in as well. If I INCREASE my preg to 50mg, you think I could lower my DHT and my E2?

Something is not right, something is as expected.
Summary, you do not have nearly enough T.

Transdermal T application increases DHT, that is what happened to you.

You have most likely did the less desirable testosterone test.
Next time do this:

Testosterone, Free, Bio/Total (LC/MS/MS)
Quest Diagnostics: Test Menu

that test have ranges
(46-224) pg/mL Testosterone Free
(110-575) ng/dL Testosterone Bioavailable

and you want to look at
BAT~575

=======================================
Your estrodial is very high.
next time test it using Quest
Estradiol, Free, LC/MS/MS (36169X)

I adjust FreeE2 (0.45 - 0.6)
check Quest's comments in the link why freeE2 is better than E2

Quest Diagnostics: Test Menu

================================================== =======
Use LiquiDex rather than Arimidex to control E2.
Sold by sponsor of this board.
I measure dose precisely using (small) insuline syringe with cut out needle.
================================================== ========
Compounded Tcream or any other transdermal t delivery is desirable only as a means of raising DHT that is use it if one have very low DHT.
Others should use T shots.
T shots increase E2, but that is manageable using Arimidex.

[beez721]

Originally Posted by JanSz

I can get Arimidex prescription but I use Liquidex.
I use insuline syringe with cut out needle to measure the dose exactly.
I use it E2D, every other day.

Sponsor of this site is selling it.
Get LiqidCia while you there.

AG-Guys & Affiliates :: Aromatase Inhibitors :: LiquiDex

I use this Quest Diagnostic test to adjust my Estrodial:

Estradiol, Free, LC/MS/MS (36169X)

I look at and adjust

FreeE2 (0.45 -0.6)

==========================
Quest Diagnostics: Test Menu


Clinical Significance:
Much of Estradiol is bound to proteins. The unbound
portion and Estradiol bound to proteins with low affinity
reflect the Free concentration. The Free Estradiol may
better correlate with medical conditions than the Total
Estradiol concentrations.

thanks for the info

[DuncanWA]

Originally Posted by JanSz

Something is not right, something is as expected.
Summary, you do not have nearly enough T.

Transdermal T application increases DHT, that is what happened to you.

You have most likely did the less desirable testosterone test.
Next time do this:

Testosterone, Free, Bio/Total (LC/MS/MS)
Quest Diagnostics: Test Menu

that test have ranges
(46-224) pg/mL Testosterone Free
(110-575) ng/dL Testosterone Bioavailable

and you want to look at
BAT~575

=======================================
Your estrodial is very high.
next time test it using Quest
Estradiol, Free, LC/MS/MS (36169X)

I adjust FreeE2 (0.45 - 0.6)
check Quest's comments in the link why freeE2 is better than E2

Quest Diagnostics: Test Menu

================================================== =======
Use LiquiDex rather than Arimidex to control E2.
Sold by sponsor of this board.
I measure dose precisely using (small) insuline syringe with cut out needle.
================================================== ========
Compounded Tcream or any other transdermal t delivery is desirable only as a means of raising DHT that is use it if one have very low DHT.
Others should use T shots.
T shots increase E2, but that is manageable using Arimidex.

All my testing has been done at Quest but I'll note those test codes and see if they coorelate to the testing ordered.

[plymouth city]

Originally Posted by DuncanWA

So you're saying preg cream could be an alternative to something like Arimidex?

I have top of the charts free T (154 on scale of 35-155 Quest), middle of the road total T (494 on scale of 250-1100), increasing DHT (96 scale of 25-75) and increasing E2 (41 scale of 13-54). Progesterone is .6 on scale of .1 - 1.2.

My treatment is 100mg of compounded T cream with 25mg preg and 5mg DHEA compounded in as well. If I INCREASE my preg to 50mg, you think I could lower my DHT and my E2?

Nope. It counteracts DHT but not E2

Rremember that DHT itself protects against E2

[plymouth city]

Originally Posted by DuncanWA

Saw my doc yesterday. We're keeping the T cream at 100mg but we're separating it out from the rest of the cocktail due to some anecdotal evidence of T being hampered by the other ingredients. We're also cutting out the HCG completely in part due to skyrocketing DHT and E2.

New regimen is:
100mg of compounded T cream
25mg of progesterone and 10mg of DHEA compounded cream. Thinking is progesterone can inhibit DHT and some E2 formation.
50mcg (micrograms) of Arimidex daily for high E2. There are some reports of daily small amounts being very effective and my new pharm can compound the Arimidex.

We're also changing compounding pharms from one here in Spokane to a Calif outfit. My doc has had some patients that have had less than predicted results w/some of the elixirs coming from there. Full retest in 3 weeks.

I wouldn't advise being on HRT without hcG

[hardasnails1973]

Originally Posted by plymouth city

You can always count on Nails.....

Pregnenolone cream is a much safer route that straight progesterone.....It causes a mild rise in progesterone, enough to counterattack the rise in DHT from T.

Plus, it boosts neural steroid production

If it counteracts tht plymouth then would that mean that your free T would actually possible raise as well as your TT level as well. Since it is preventing T converting to DHT? just currious

[plymouth city]

Originally Posted by hardasnails1973

If it counteracts tht plymouth then would that mean that your free T would actually possible raise as well as your TT level as well. Since it is preventing T converting to DHT? just currious

Yes, there is such thing as DHT dominance - The brain is tricked into thinking the body as enough Testosterone when it has very high DHT, so the HTPA spits out less LH, and in a case with high DHT you can possibly lower T. In such a case where very high DHT is present, adding Pregnenolone will boost T due to the feedback loop.

[hardasnails1973]

Originally Posted by plymouth city

Yes, there is such thing as DHT dominance - The brain is tricked into thinking the body as enough Testosterone when it has very high DHT, so the HTPA spits out less LH, and in a case with high DHT you can possibly lower T. In such a case where very high DHT is present, adding Pregnenolone will boost T due to the feedback loop.

Thank you bro that would involve my case of 3 times the high end of dht levels. !!
Now do you know where to get 50 mgs pregnolone creame LOL. I wish eeric would come out with TRT formula
40 mgs preg and 15 mgs DHEA with dim, reservatrol.. That would be the bomb with there delivry system

[JanSz]

Originally Posted by hardasnails1973

Thank you bro that would involve my case of 3 times the high end of dht levels. !!
Now do you know where to get 50 mgs pregnolone creame LOL. I wish eeric would come out with TRT formula
40 mgs preg and 15 mgs DHEA with dim, reservatrol.. That would be the bomb with there delivry system

Call womens intntnl
They can definitely mix
preg
dhea
T
Chrysin

in any desirable proportion.
They may have other ingredients.

I am expecting my compounded preg gel to arrive any day.
Switched to gel after I heard that sometimes it makes a diference.

Wonder if it will pay out, gel is more expensive and thinner,
instead of 100mg/mL it comes as 50mg/mL
plus it have a little larger spoon to get 1gram.