Men's Health Forum: This is a discussion on Reverse T negative feedback within the Anabolic Steroids forums, part of the extensive steroid information at MESO-Rx; However, remember the aforesaid dosage and administration is probably for the intended purpose of the drug which is Muscle Relaxant-Antispastic. ...
However, remember the aforesaid dosage and administration is probably for the intended purpose of the drug which is Muscle Relaxant-Antispastic. I intend to be much more cautious until optimum effect is achieved. Therefore I will more or less follow the guidelines in the human study link herein this thread effects of baclofen on IGF-I. which is....
"Patients received escalating doses of baclofen for 4 weeks at each dose level (5, 10, and 20 mg/d). "
However, I will make one change....I will do 4 weeks at each dose level but @ 5,10,15,20 mg/d and so on until optimum level is achieved.
I will order my labs every month to monitor my progress. I will use directlabs.com (save about 50-66% on labs and doctor visit) thus, I don't need a script from my doc and they will send the labs directly to me by e-mail.
If you're in the USA and you desire monthly testing as I do, directlabs.com is the only way to go IMHO. Otherwise, it would be cost prohibitive to pay a doctor visit every month plus their markup on the tests. You basically are getting the tests wholesale through DL at the same price the doctor pays.
Also, DL uses LabCorp thus, all you have to do is go to LabCorp web-page and locate a service center near you - third tab from the left at the top of the page. DL has many tests listed on their web page. However, if you don't find a particular test just go to LabCorps page and click on the corresponding first letter of the test you desire and your options will come up. For example, click on L for Luteinizing Hormone. Once you have LabCorps test number of the test you desire (assuming you did not find it on DL's web page) then call Leigh Wilkerson on DL's 800 number. She is a friend of mine and will give you a great price.
"However, remember the aforesaid dosage and administration is probably for the intended purpose of the drug which is Muscle Relaxant-Antispastic. I intend to be much more cautious until optimum effect is achieved. "
Yes- no doubt.
Sounds like a good plan there. Are you currently on trt ?
You got two threads goin on about the sme thing. I post to the other one in the future. Btw, glad to have you aboard.
Hey, thanks for the testing deal. My current plan is to have the VA do the all testing, assuming that my GP is cooperative, which may not be the case. The oneline available testing that I am familiar with isnt exactly cheap.
What other thread? I quit posting on the other threads as I was duplicate posting of which was not efficient use of my time.
As far as my story.... In my late 30's i was concerned over losing my hair. Unfortunately for me, my doc prescribed Propecia (Finasteride) and within a month or two I began having emotionally disturbing side effects. I stopped the drug immediately believing the drug company/doctor that I would return to normal afterward. Instead, my symptoms progressively got worse over the years and a healthy young man turned old with premature Andropause.
I am an inventor,/engineer thus, research is my middle name. Due to experience and some inside scoop on the medical industry through some very good doctor friends, I have learned over the years that many doctors know little more than we do when it comes to matters other than surgical as is the case with my original doctor prescribing Finasteride and not informing me of the potential consequences of same.
Therefore, every time the doc wanted to put me on TRT it just didn't make sense to me. I wanted to find out more about steroid hormones and the negative feedback loop and what exactly could be done to stimulate GnRh to produce LH because I didn't like the fact of using HCG which only mimicked LH which would not allow me to monitor HCG/LH other than a guessing game, etc., etc. If all the questions weren't answered then I was not willing to be a test subject.
Is Baclofen the answer? Too early to tell. But for me, after much research, it is the first drug that I am willing to test on myself and if you knew me...that says a lot . If all goes well, hopefully, my T will be in the optimum range and I won't have to do TRT, if not, I will look forward to TRT for the first time and hopefully without the dreaded fear of T Negative feedback assuming Baclofen does at least that.
To put it in perspective, if all Baclofen does is eliminate the negative feedback of steroid hormones, specifically T, (with no, or minimal, side effects) IMO, it stands to revolutionize anti-aging medicine and bodybuilding assuming the drug companies and/or government doesn't step in and take it off the market because of the competing factor with much more expensive popular drugs and less need for doctor intervention.
Not to imply that doctors don't have their role, but it makes sense to me that the simpler things get the less need for medical care and therefore, the medical establishment has bias to keep it as complex as possible.
My interests range from finding better treatments for andropause and menopause to asthma and memory loss. Which I am treating in myself and my wife- sometimes with MD help and sometimes not. I have had a love of chemistry and drugs since junior high school and have persued both academically and expermentally ina personal manner. Needless to say, I find the biochemistry the most interesting. But medicine ingeneral has a great deal allure.
I confess I havent read all the studies you posted but will soon. I also confess that I dont have a great deal of confidence in baclofen being an alternative to conventional TRT. I think if the effect on T were favorable someone would have been noticed by now. Baclofen has been around a long time. have ever heard any anechdodal evidence fo rit.But Im just playing the devils advocate.
Sorry guys, I could not change the title of the thread as requested. I'm really enjoy what is being said of the baclofen. Never heard of the stuff. I'll have to plug it into PUBMED and see what turns up.
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And we'll collect the moments one by one.
I guess that's how the future's done.
Feist, "Mushaboom", 2005.
I found that this medication is a GABA agonist used to treat spasms. Abrupt withdrawal puts someone at medical risk. Overdose can result in coma. It is chemically similar to Phenibut--another GABA agonist (which is available OTC). I guess we are all looking for one pill does all. My hope is that the end product of a SARM is the answer.
If you are going to do this, please keep us informed. The lab work will help alot. Good luck.
__________________
And we'll collect the moments one by one.
I guess that's how the future's done.
Feist, "Mushaboom", 2005.
The problem with SERMS is that this science is still in its infancy and they have been known to cause impotency. In fact, it is my understanding that Nolvadex has now been discontinued as breast cancer treatment in males due the magnitude of complaints and many women being treated by same also have this complaint. There are some real horror stories out there regarding impotence and the use of SERMs and since many share the same structure I would not be so quick to say this problem is exclusive to Nolvadex.. Hence, I no longer trust SERMS.
Anyway, it seems like all these expensive, complicated, treatments such as SERMs are doing just that...providing expensive, complicated, answers. Where there is complication, there is confusion, with no clear answers and the next drug is produced, then the next one, and so on, and so on. .
I believe the powers to be want it to remain that way as I stated before because they have a vested interest named the almighty dollar. Call it capitalism at its best, or at its worst, but as long as we the people subscribe to that manipulation and keep searching when the answer may be under our nose big pharma will keep on pumping out the propaganda.
Respectfully, lets look at another example of simplicity......
"Following baclofen administration, plasma GH rose in healthy males.....orally 10 mg of baclofen, the direct GABAB agonist which freely crosses the blood-brain barrier"
So far this boring, cheap, drug that has been around for such a long time that all anti-aging docs have forgotten about it, by accident, or by design, has proven in scientific studies to be......
1) safe with no, to minimal, side effects when taken in proper dosage as advised
2) raise LH which we know raises T
3) reverse T negative feedback which helps us utilize T more effectively
4) increase IGF-I (do you know how much people pay for this stuff when this pill provides it for pennies?)
5) increase GH ( do you know how much people pay for GH when again this pill provides it for pennies)
and much more to come...stay tuned
I don't mind a devil's advocate because it brings balance to evaluation. However, respectfully, an informed mind makes a better devil's advocate which is why I post the links.
PS: In regards to your prior comment on baclofen and TRT. I'm not saying it will replace TRT because the verdict is still out. However, common sense based on studies would lead one to believe that this indeed could be the "magic pill" and revolutionize TRT and change it as we know it today. Here's why......
Many of the same protocols that anti-aging medicine subscribes to, this one little pill provides according to the scientific studies. Also, keep in mind the main difference between body building T utilization and anti-aging T utilization is the amount of T desired to achieve a satisfactory goal. Hence, those interested in anti-aging typically require only a nominal amount of T because they typically desire to be in the upper range of test results while those in bodybuilding are competitors/athletes desiring to push the envelope for that competitive edge.
Thus I submit, that it is logical to assume based on the studies that there is a chance that the male anti-aging candidate may indeed reach his T goal with the use of baclofen whereas, it is less likely the body builder will because his/her requirements are typically much higher. Even so, if baclofen does what the studies show it will do, do you know what that will mean to the body building regime. It will be revolutionary eg.,.....no more worry about the cycle as it relates to HCG and T because HCG will be obsolete, no more worry about testicular or penile shrinkage, etc., etc., etc.
Re: Reverse T negative feedback 
Re: Reverse T negative feedback 
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