Reverse T negative feedback

[zkt]

The reason for exploring the effects of Gabapentin on LH was to gain insite into the mechanism of Bclofens action. Most of the research involving Gabapentin concerns epylipsy and menopausal hot flashes. LH seems to be involved in the proceses abut I didnt find any direct evidence that Gabapentin increases LH.

[zkt]

Originally Posted by Jtay

ZKT,

I just read about your circumstance. How have you been testing your cortisol? Have you ever done a diurnal cortisol saliva test? It would be interesting knowing the results. Also, would like to know your cholesterol test results and pregnenelone if you have it. Cholesterol is the first step in bio-sythesis of steroid hormones. High cholesterol, low preg may tell us something about your P450.

Ever read the book our stolen future? A good read and the authors make a valid case as to why Andropuase is at record levels and rapidly progressing. Also, take a fasting insulin test if you haven't already. This will indicate whether or not your insulin resistant .

Also, I'm sure you have a blood glucose monitor. Take your levels when you wake, when you go to sleep, before you eat, and 30 minutes and 1-hour after you eat and let me know.

I am not giving medical advice here as I am not a doctor. However, I may have some interesting observations.

Yes Preg, Progest, DHEA and a four point cortisol test on my list and are waiting for approval from the VA. My glucose has always been normal but thats a good idea to check the fasting level. Thanks, will add it. LDL total cholesterol(C) and HDL are tested frequently will have latest results soon. I`ll keep you informed. Re. the C situation; currently on Crestor and Zetia and Gemfiprozil 600mg/D for triglycerides. I am launching an all out attack of the LDL-HDL ratio by increasing the Gem to 600Mg/2XD and starting niacin 400mg/D at bedtime and titrating up to 1g/D.Studies haave found that this regimine can increase HDL by almost 50%.
Betrter living thru modern chemistry !

[Jtay]

Originally Posted by Matt Muscle

Well, Baclofen sounds similar in some respects to GHB, in regard to it also being a GABA agonist and that it has Growth Hormone releasing properties. Interesting.

"GHB and related compounds continue to be abused, although the effects of these compounds are different from previously characterized drugs of abuse. A rapidly growing literature, including data obtained in this newly developed drug discrimination procedure with baclofen, strongly implicates GABAB mechanisms in the behavioral actions of GHB. That baclofen is not abused (like GHB) could be due to differential effects of these compounds at GABAB receptor subtypes, to different mechanisms (direct versus modulation) of action at the same GABAB receptors, to actions on non-GABAergic systems, or to nonpharmacologic factors (availability) that can dramatically influence recreational drug use."

Here is the full scoop comparing GHB with Baclofen. For those that don't want to be bored with the science just go direct to the "Discussion".

http://jpet.aspetjournals.org/cgi/co...full/309/2/540

[Jtay]

This is important to note now that the discussion of Baclofen and GHB is taking place:

FOR THOSE THINKING THAT BACLOFEN CAN BE SUBSTITUTED FOR GHB FOR THE PURPOSE OF RECREATIONAL DRUG USE/ABUSE, THINK AGAIN.

Another reason why Baclofen may indeed be the "Magic Pill". It provides all the benefits of GHB without the addictive traits which means you wont get the same addictive stimulation/euphoria as with GHB although you will get the same heath benefits and even better. I have another study of which I have to locate that shows Baclofen as 60% more effective that GHB in this regard if my memory serves me correct.

It is important to note that GHB has much history of helping people and is still used in medicine in this regard. It was not until GHB became a recreational drug of choice that it gained a darkened reputation.

[Jtay]

In fact, some doctors prescribe baclofen to help wean those addicted off of GHB.

[Jtay]

Also, regarding dosage......

Remember, the more you spread it out the better effect you will have and the less likely you will get the undesirable sedative/sleepy effect unless you desire to use it as a sleep aid that is.

"Peak plasma concentrations of baclofen are achieved within 2 hours and the plasma half-life is 2 to 4 hours. "

"The half-life of a quantity, subject to exponential decay, is the time required for the quantity to decay to half of its initial value."

In consideration of the above, you can clearly see with the half-life occurring in 2-4 hours why taking the drug every 4-8 hours is ideal. Obviously, you can't take it every 4 hours or else you would have to wake up at night . Therefore, taking it every 6 or 8 hours is ideal. The directions recommend every 8 hours (3x daily) which is what I will adhere to as I desire 8 hours of sleep although I seldom get it.

In furtherance of my prior post regarding the dosage I plan to start out with.....

I will buy the 10mg tablets and half them (they are scored). I will start with 5mg every eight hours (3x daily) for a total of 15mg/d.

Also, a big pharma in China also makes this drug. Considering the controversy with China meds , I would be sure to check with your pharmacy to ensure the manufacturer is a reputable manufacturer.

If you are buying the Generic brand in lieu of the brand name, Lioresal, go to this link and it will give you all the manufacturers and photos of each pill so you can confirm you are getting the real deal.

http://www.drugdigest.org/DD/DVH/ListImages/1,20242,64|1,00.html

Another brand name is Kemstro however, I'm leery of this brand because their literature indicates it doesn't cross the blood brain barrier (BBB) when in fact, all the science says baclofen freely crosses the BBB and Lioresal confirms this as well. This conflict is strange and can probably be cleared up with a phone call to, Kemstro, however, for me, I will stick with Lioresal or one of the repuatable generics (at a huge cost savings) on the link above.

canadadrugs.com or usdrugs.com are repuatable to the best of my knowledge.

Also, the aforesaid is.....

NOT TO BE CONSTRUED AS MEDICAL ADVICE.

IT IS ALWAYS RECOMMENDED THAT YOU SEEK ADVICE FROM A LICENSED MEDICAL DOCTOR

[Jtay]

Here is the generic drug link again. I don't know why I'm having trouble with the links.

http://www.drugdigest.org/DD/DVH/ListImages/1,20242,64|1,00.html

[Jtay]

Just copy and paste it. I don't know why it wont post as a link you can click on.

[zkt]

" Remember, the more you spread it out the better effect you will have and the less likely you will get the undesirable sedative/sleepy effect unless you desire to use it as a sleep aid that is."
Clearly the second part of the statement is true but I doubt the first.The drugs effect is directly related to serum concenration over time. The area under the curve of time vs serum concentration will represent the total effect and will be the same regardless of dosing interval. The question is: do the testes respond only to absolute serum levels or are they also responsive to the rate of change of LH ? I suspect that since the bodys normal production of LH is pulsitile rather than steady state, the testes rospond to the sudden increase in LH as well as the concentration. However, this is only conjecture on my part. Although it doesnt seem to effect me this way the fact that sleeyiness is a common side effect might dictate dosing.

[Jtay]

Originally Posted by HeadDoc

it's good to have you here. You bring something new. Once the initial exchanges finish, I hope that you will stay and give us feedback on your proposed trials in this thread.

Head Doc,

I've been thinking about this and here are my thoughts,

First, I am here because I desire to help others with information about a forgotten drug, baclofen, and how it may revolutionize anti-aging and body building medicine if user results are in-line with the scientific studies.

Although the drug and scientific studies have been around for a long time, it took me 3+ years to discover them with countless hours of research including but not limited to the possible causes of my premature andropause and the possible cures for same.

Due to my engineering and research background, I was not willing to accept conventional protocol as it just didn't make since to me that they were treating the symptoms and not the disease itself. For one example, why would I put T in my body if it was at the bottom of the hormone chain and it was going to result in infertility, reduced semen, hypogonadism, baldness? I wanted to find out why T and other steroid hormones caused a negative feedback, what factors increased or decrease T, what role the GnRh played in the production of LH and T and why it couldn't be successfully stimulated for a long period of time etc., etc., etc?

For a while I would get thrown off course by the likes of so-called "advanced medicine" and the next great thing, that confusion would often set in not unlike the average person trying to weed through the maze of options and opinions . But then I would remembered two old adages that where instilled in me as a young man and that had resulted in my success....

"The more things change, the more they stay the same" and
"Keep it simple stupid"

So I returned to basics and tuned out modern day medicine and just like good old detective work, when a person's name surfaces time and time again, he/she becomes the main suspect, I remembered that during my research one possibility kept coming back to me time and time again.... the GABA B receptors.

So I focused my research in that area dissecting GABA B agonists, antagonists, GABA B positive receptor modulators, opiod agonists and antagonists etc., etc., etc. That research narrowed it down to two....GABA B agonist and Opiod agonists/antagonists which is currently where I believe the riddle will be solved.

So how did I rediscover baclofen and connect it with anti-aging and body building medicine?

I visited another thread about people who attribute their many health problems to the use of finasteride (propecia) of which, I am one. On that thread there was a young man telling of his incredible story of how he beat his devastating problems, which was basically premature andropuase, with a drug known as GHB. Most did not give him credit and a few even implied he was lying or even crazy.

However, I could feel the conviction in his written words and unlike the rest, I had knowledge that GHB was tied to the GABA B receptors of which, coincidentally is where I had narrowed my research down to. So I Googled GHB GABA B and wha-la, Baclofen!

As study after study confirmed that Baclofen provided the missing links in anti-aging and body building medicine, I was stunned and I still am, as I'm sure many of you monitoring this thread are.

I assume due to the interest this thread has generated in such a short time that some of you are going to try baclofen because it is a relatively safe drug with little downside and huge potential. In fact, I have already had some e-mails confirming this to be the case. Needless to say that any/all personal experiences to confirm or deny the scientific studies would be helpful.

*******I also want to make myself very clear....I am not encouraging or advising anyone to take baclofen. I am not a medical doctor and my advice is to seek council with a licensed medical doctor before trying any prescription medication. If you take baclofen you should do so under the guidence of your medical doctor.******

So all I ask in return for my sharing with you my findings, is that if you decide to try baclofen that you report your experience and post your labs (if you are using tests to monitor your progress that is) therefore, we can all benefit accordingly.

Head Doc, is it possibly to start a sticky thread for for members to share their personal experiences with baclofen? If so, maybe the heading...

Baclofen - The Magic Pill ? - Personal experiences.

We can keep this current thread for discussion and the new thread only for reporting personal experiences by those that have used or are currently using baclofen.

Just a thought. If not possible, no prob.