Men's Health Forum: This is a discussion on SHBG low ; what can it indicate ? within the Anabolic Steroids forums, part of the extensive steroid information at MESO-Rx; My latest SHBG was :
SHBG 17 ( 10 - 73 )
But I have low Total T, therefore what ...
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SHBG low ; what can it indicate ?
Quote:
Originally Posted by chip douglas
My latest SHBG was :
SHBG 17 ( 10 - 73 )
But I have low Total T, therefore what can this low SHBG can reveal in terms of relationship to other hormones such as Estrogens and insulin ?
SHBG is reduced by: high insulin (insulin resistance/diabetes), low thyroid, high testosterone, high DHEA, high growth hormone, low estrogens, low progesterone, high dihydrotestosterone
SHBG is increased by: low insulin, high thyroid, high estrogens, high progesterone, low testosterone, low DHEA, low growth hormone, low Dihydrotestosterone.
Low SHBG increases Free Testosterone.
High SHBG reduces Fress Testosterone
The hormone with the strongest effect on SHBG is insulin.
Low SHBG is most often strongly correlated with diabetes or insulin resistance.
High androgen levels such as the use of supraphysiologic doses of testosterone can also drive SHBG down.
Most cases of insulin resistance/type II diabetes start with hypothyrodism (low thyroid hormone levels). Treating thyroid hormone deficiency can prevent the development of insulin resistance and diabetes. Once the horse is out of the barn - and diabetes type II is present, increasing thyroid hormone alone may not always reverse insulin resistance since other hormone imbalances may occur to perpetuate insulin resistance (e.g. testosterone deficiency or adrenal fatigue - which in turn worsens conversion of T4 to T3, etc.) or end-organ damage may occur which may be irreversible. Insulin resistance itself can worsen thyroid function - thus causing a positive feedback loop or death spiral - by causing loss of zinc and iodine and by causing nervous system damage. This is where the relationships between hormone systems and nutrition become highly intricate and undoing problems can become complex.
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SHBG is reduced by: high insulin (insulin resistance/diabetes), low thyroid, high testosterone, high DHEA, high growth hormone, low estrogens, low progesterone, high dihydrotestosterone
SHBG is increased by: low insulin, high thyroid, high estrogens, high progesterone, low testosterone, low DHEA, low growth hormone, low Dihydrotestosterone.
Low SHBG increases Free Testosterone.
High SHBG reduces Fress Testosterone
The hormone with the strongest effect on SHBG is insulin.
Low SHBG is most often strongly correlated with diabetes or insulin resistance.
High androgen levels such as the use of supraphysiologic doses of testosterone can also drive SHBG down.
Most cases of insulin resistance/type II diabetes start with hypothyrodism (low thyroid hormone levels). Treating thyroid hormone deficiency can prevent the development of insulin resistance and diabetes. Once the horse is out of the barn - and diabetes type II is present, increasing thyroid hormone alone may not always reverse insulin resistance since other hormone imbalances may occur to perpetuate insulin resistance (e.g. testosterone deficiency or adrenal fatigue - which in turn worsens conversion of T4 to T3, etc.) or end-organ damage may occur which may be irreversible. Insulin resistance itself can worsen thyroid function - thus causing a positive feedback loop or death spiral - by causing loss of zinc and iodine and by causing nervous system damage. This is where the relationships between hormone systems and nutrition become highly intricate and undoing problems can become complex.
Hi Marianco,
Thanks for the clear reply to my initial query. My Dihydrotestosterone is high normal at :
Dihydrotestosterone : 1 599 pmol/L ( Ref. range [men age 20-49] : 217 - 1650)
Bioavailable T was : Bioavailable Testosterone 7.0 ( 2.0-14.0) nmol/L
E2 was : Estradiol-17B 93 men : 42-151 pmol/L
and SHBG : SHBG 17 ( 10 - 73 )
I'm going for a Cortrosyn trial in less than an hour this morning. Plus, last week I another whole hormone, chemistry, urinalysis performed, so should be getting a lot of test results in about a week from now with fresh readings. I can tell you with confidence that the only symptom that persists is the low sex drive, all else is now fine.
Marianco, what you have written really sounds familiar to my situation.
Is there anything that can be done about insulin resistance? I eat well, train regularly, and am of a healthy bodyweight. I've found taking r-ala has improved my well being significantly. Is there anything else that can be done?
Marianco, what you have written really sounds familiar to my situation.
Is there anything that can be done about insulin resistance? I eat well, train regularly, and am of a healthy bodyweight. I've found taking r-ala has improved my well being significantly. Is there anything else that can be done?
For inuslin resistance chromium, vandium, zinc, magneisum defieincy have been associated.
Gynemma may be of help as well. Its an indian herb that has been used for 1000 of years known as the sugar destroyer. Chip this goes right back to your elevated homocysetine levels and insulin resistance. See the vicious cycle?
Last edited by hardasnails1973; 03-16-2007 at 10:55 AM.
For inuslin resistance chromium, vandium, zinc, magneisum defieincy have been associated.
Gynemma may be of help as well. Its an indian herb that has been used for 1000 of years known as the sugar destroyer. Chip this goes right back to your elevated homocysetine levels and insulin resistance. See the vicious cycle?
Yep, from what Marianco said, insulin is what has the most impact on lowering SHBG. There's also my DHT which can lower it, which is high normal as you could see. My testosterone is also low. Now would it be correct to think that insulin can lower LH ?
That being said, i know that if I take fish oil now, I'll be horny later on this evening. Now what does fish oil alter that makes it work that fast on me ?
I know that fish oil has some effect on both serotonin and dopamine, and on NO. It also has effects on HDL/LDL and triglycerides.
Since fish oil helps a lot in restoring my sex drive, doesn't this reveal something through it's effect ?
Yep, from what Marianco said, insulin is what has the most impact on lowering SHBG. There's also my DHT which can lower it, which is high normal as you could see. My testosterone is also low. Now would it be correct to think that insulin can lower LH ?
That being said, i know that if I take fish oil now, I'll be horny later on this evening. Now what does fish oil alter that makes it work that fast on me ?
I know that fish oil has some effect on both serotonin and dopamine, and on NO. It also has effects on HDL/LDL and triglycerides.
Since fish oil helps a lot in restoring my sex drive, doesn't this reveal something through it's effect ?
Your DHT and E2 are the problem my SHBG is 22 but my Total T is up in the upper 1/3 of my labs range. And I keep my E2 down between 15 to 20 lower SHBG is much better the higer.
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SHBG low ; what can it indicate ? 
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