Thyroid Hormone and Testicular function (Excellent article)

[Megazoid]

Just printed and read this. This is one of the few articles i could find that speaks directly about the effects of thyroid hormone on testicular function, fertility and hormonal parameters (SHBG and so fourth).

Link here guy's, let me know what you think.

It seem's clear that hypothyroidism causes all manner of testicular abnormalities and problems, can't understand why i felt so bad on T4/Pred combination. Will be restarting the prednisone again next week.

Article link here:

http://edrv.endojournals.org/cgi/reprint/16/4/443.pdf

[zkt]

Looked the paper over and its a keeper for sure. Whats your thoughts on it? Ill read it later.

[Megazoid]

Low T3 causes a whole host of testicular development and maintenance problems leading to germ cell issues and sex hormone secretion problems.

It also goes on to discuss how LH (and HCG) both fail to work in situations with low T3 thyroid hormone. So this explains why a few guy's on this forum haven't had any luck with HCG treatment restoring testicular size. And if my memory serves me right they all have thyroid problems (elevated TSH's above 2 - low free t3). This also explains why some guy's with high E2 have ED and libido issues due to low thyroid hormone.

I believe low T3 eventually leads to testicular malnutrition that can lead to atrophy and various other problems. This explains my own situation.

It also states impotence and loss of desire is linked with hypothyroidism. It's worth reading over for sure as it discuss more indepth the links with SHBG and thyroid.

[eeso]

Damn you've come a long way megazoid! I remember when you first joined here you had absolutely no idea. Now you're one of the best contributers on the board! You're obviously a very intelligent person and I'd like to thank you for sharing your research here.

[leed]

Originally Posted by eeso

Damn you've come a long way megazoid! I remember when you first joined here you had absolutely no idea. Now you're one of the best contributers on the board! You're obviously a very intelligent person and I'd like to thank you for sharing your research here.

Agreed - mega has given me inspiration to unlock my body from 5 years of problems - thankyou for your strength

could someone copy / paste (not sure if you can with .pdf) into a post - im having issues downloading this file?

Lee

[masterpp]

i couldnt agree more-

good work man as ever

[masterpp]

although i cant download the link

[Megazoid]

Wow! thanks for the nice comments guy's, truelly means allot to me. I basically just want to get out of this mess and on with my life (getting a girlfriend, finishing some applications i am developing and continuing to compose and produce music - my passions in life!). In doing this research i really want to help as many people as humanly possible.

This forum has helped me so much in the past, when i have been down and depressed everyone was there for me and helped out, i don't think i will never be able to put that thank you in words. I know that if we all work together here, exchange symptoms, ideas and medication experiences we can beat this stuff and live normal lives. Some of us already are doing this and it's truelly great to see and brings some hope of beating this.

Regarding the link, this one should work:

Send big files the easy way. Files too large for email attachments? No problem!

[masterpp]

great read- but it suggests that the window of thyroid activity stimulating testicular development is very narrow, and limited to puperty- p454

from my understanding of the article, it suggests that once you pass through puberty, the relationship between gonadal growth and thryoid isnt so relevant.

im therefor not sure if we can really treat thyroid dossing as some kind of treatment for testicular inactivity.

[Megazoid]

I noticed that too but i wouldn't out rule the importance of thyroid hormone. It's still a quoted claim for impotence, infertility and other problems. Allot of the time the mechinism itself isn't understood either.

My theory on this is simple. Having higher levels of free T3/T4 results in better blood circulation to nurish and supply nutrients and such like for your testicles to function. I have noticed all around my body dry, hardening skin that dosen't feel good like before (good sensation, smooth, moist, etc). If it's doing thing's like this to my hand's and feet i can only imagine what it's doing to the delicate fibirious chambers within the testicles. Low thyroid hormone leads to all kind of problens and poor circulation to pherial body parts can't do your nut's any favors (considering varicocele itself caused disturbances).

My thoughts on this are: Get adreanl support done properly (optimized cortisol,DHEA and pregnolone if needed), add in thyroid support (get free t3/t4 to top of the range) and THEN look at sex hormones a few months later and add if needed. Low cortisol/adrenal fatigue will mess everything up.