Why am I not seeing any effect from steroids or t3?

[Warrior21]

Just as the subject says. Why is it that I see no results from steroids or t3 ingestion? Does adrenal fatigue play a role in steroid hormone/thyroid uptake ?
Well come to think of it, I know (or have read) that adrenal fatigue does cause thyroid hormone resistance, but what about steroids? Are there not any of you right now on steroids who may have been adrenally fatigued at some point in time? Do you obtain results from steroids no matter what your adrenal conditions?
Another idea I thought was a partial receptor block. After reading Jeffries book (Safe Uses of Cortisol) I'm very interested in seeing what would happen if I got on a conservative dose of hydrocortisone to see if I could actually shuttle steroids/thyroid into my cells. There were a couple of studies in Jeffries book which show that hydrocortisone therapy 'cures' thyroid hormone resistance.
Looks like I need it, because I am hypothyroid as well. On top of that I also wonder. My bloodwork comes back with low estrogen levels, but I seem to have some estrogen dominance going on? My fat patterns are very female. I have a lean upperbody, but I cannot lose the fat on my thighs/glutes for the life of me. On top of that, I also tend to retain plenty of water.
For what it's worth, I had gynecomastia when I was 13 until about 18 (surgically removed), and around 18 years old was the same time I started losing my hair. Now I'm 20 and show significant hairloss.
Sorry for the messy post format, but I guess any input at all on this is appreciated.

[eeso]

I've been on TRT only and felt good for a while, then no good.

Been on Armour only - felt good for a while, then no good.

Definitely you can feel shit on trt/thyroid therapy if your adrenals suck. I'm starting from square one now and treating adrenals before anything else.

[JanSz]

You can test, find what is out of range and then make attempt at correcting those.
To have any chance at success the testing should be extensive, to the point (logical), done often enough at good laboratory.
If you want to do that, then:

Post your complete blood test.
Name, value, units, range performing laboratory.
Post all your medicines and supplements and their schedule.

[Warrior21]

OKay thank you for the right attention. I've been insulted on other forums and bombarded with comments like "your gear is fake" and "your diet sucks".
I have bloodwork taken just 2 weeks ago.

6:30am cortisol 29.5 reference 4-22
FSH 1.7 reference 1.6-8.0
LH 2.8 reference 1.5-9.3
Progesterone 1.3 reference <1.4
Testosterone 543 reference 241-827
TSH .51 reference .4-4.50
estradiol <7 reference 13-54
free t3 283 reference 230-420
IGF-1 223 reference 126-382
Fasting Glucose 77 reference 65-99
DHT 30 reference 25-75
DHEA 529 reference 180-1250
T3 reverse 10 reference 11-32
SHBG 26 reference 7-49
Pregnenolone 37 reference 10-200

I'd like to increase my DHEA,IGF-1,Test,T3,Pregnenolone, and LH.
And why do I have symptoms of estrogen dominance (hairloss, bloat, thigh/butt fat) if my estrogen is so low?
I know my AM cortisol is high, but keep in mind symptoms of high cortisol in adrenal fatigue are similar to low cortisol.
My symptoms are: Thyroid Hormone Resistance, Steroid Hormone Resistance, hypothyroidism, fatigue, hairloss, difficulty losing weight, easy to gain fat. Feel dizzy when standing up, low blood pressure, lack of ambition to do much, feel pain when putting pressure on my kidneys (in MMA if I am ever on my side the pain is real bad), occasional rapid heartbeat, occasional blurry vision (low blood sugar).
So it seems I have plenty of symptoms of adrenal fatigue. I also have sub clinical problems with estrogen it seems.

[JanSz]

Originally Posted by Warrior21

OKay thank you for the right attention. I've been insulted on other forums and bombarded with comments like "your gear is fake" and "your diet sucks".
I have bloodwork taken just 2 weeks ago.

6:30am cortisol 29.5 reference 4-22
FSH 1.7 reference 1.6-8.0
LH 2.8 reference 1.5-9.3
Progesterone 1.3 reference <1.4
Testosterone 543 reference 241-827
TSH .51 reference .4-4.50
estradiol <7 reference 13-54
free t3 283 reference 230-420
IGF-1 223 reference 126-382
Fasting Glucose 77 reference 65-99
DHT 30 reference 25-75
DHEA 529 reference 180-1250
T3 reverse 10 reference 11-32
SHBG 26 reference 7-49
Pregnenolone 37 reference 10-200

I'd like to increase my DHEA,IGF-1,Test,T3,Pregnenolone, and LH.
And why do I have symptoms of estrogen dominance (hairloss, bloat, thigh/butt fat) if my estrogen is so low?
I know my AM cortisol is high, but keep in mind symptoms of high cortisol in adrenal fatigue are similar to low cortisol.
My symptoms are: Thyroid Hormone Resistance, Steroid Hormone Resistance, hypothyroidism, fatigue, hairloss, difficulty losing weight, easy to gain fat. Feel dizzy when standing up, low blood pressure, lack of ambition to do much, feel pain when putting pressure on my kidneys (in MMA if I am ever on my side the pain is real bad), occasional rapid heartbeat, occasional blurry vision (low blood sugar).
So it seems I have plenty of symptoms of adrenal fatigue. I also have sub clinical problems with estrogen it seems.

free t3 283 reference 230-420

You have to get FreeT3 up to 420, top of upper range.
Also get FreeT4 to the top.
You need about 4 grains of Armour, then do blood test again for fine tunning.
But;
you will be better off if you try using Synthroid (T4) or generic T4, first.
If your body is able to convert T4 to T3 you would be better off.
If not, use Armour.
All precaucions on ramping up with Armour apply.
=================================================
estradiol <7 reference 13-54
DHT= 30 reference 25-75
TotalT= 543 reference 241-827
SHBG 26 reference 7-49

You can either do agonizing, intelectualizing and time consuming research
or
start using Testosterone shots right away.
SHBG= 26
Table in my post #40
Jan's BloodTest April13/2007 - Page 2
155 1087 26.4 300 xx38 250

use 155mg/week, re-test and adjust dose within 6 weeks to 3 months
goal is
FreeT~300
use chart on post #41 to figure it out, do not test for FreeT
Do testosterone injections on E3D schedule.

Do HCG Novarel shots.
Best 250iu on days between T shots.
I do T and 500iu on same day, for convenience

Test injections are known to increase E2
Hopefully just to the right level.
Get LiquDex, so you have it near by.

Hopefully your DHT will inch up.
=================================================
Get prescription compounded Pregnenolone cream 100mg/1gram
at WomensInternational. You doc can call in the script, no need writting.
Use 2grams/day
=================================================
DHEA 529 reference 180-1250
Get DHEA slightly over your top range.
Use 2 pills
DHEA Complete
100 mg 7-Keto® DHEA & 25 mg DHEA, 60 capsules
Item Catalog Number: 850
Dhea Complete, 60 Capsules

and
one pill
DHEA (Dehydroepiandrosterone) Free Base
100 mg, 60 capsules
Item Catalog Number: 883
Dhea (Dehydroepiandrosterone) Free Base, 100 Mg 60 Capsules

LEF ships all over the world.
=================================================
Get
Cortef 5mg
You are going to start on Synthroid first, for now Cortef may not be as important.
If/when you start on Armour and see that you have dificulty raising the dose
then
go for Cortef, ramp up slowly up to 20mg ( sometimes 30mg)/day
stay on Cortef at least for 6 months before trying to go of off it.
After you are on 20mg Cortef, work on your Armour dose.
If all this advice is not working for you;
go back
do a good adrenals test
you may need Medrol rather than Cortef, you may need Florinef in addition to Cortef or Medrol.
==================================================
For the problems that we discussed here do following blood testing,
best if you can arrange the tests at Quest Diagnostics.
It is USA lab but have a presence all over the world.
Blood drawn at Quest, on the day of the T shot, before shot.

T3 Free
T4,Free
T4,Total
DHEA sulfate
Prolactin
Progesterone, LC/MS/MS
Pregnenolone
Estradiol, Free, LC/MS/MS (36169X)
Estrogens, Fractionated, LC/MS/MS (36742X)
Estrogen, Total, Serum (439X)
Testosterone, Free, Bio/Total (LC/MS/MS)-
Dihydrotestosterone, Free, Serum (36168X)

and
urine testing at Genova Diagnostics, also international presence

EstroEssence
Genova Diagnostics EstroEssence
==================================================
You should do more complete testing

I suggest my list on post #44
Jan's BloodTest April13/2007 - Page 2

Start with blood test.

Consider
(GDX - Metabolic Analysis Profile) including (GDX - Cellular Energy Profile)
Essential and Metabolic Fatty Acids Analysis
==================================================

After you do correction as outlined above,
we may discuss further improvements.

Good luck.

I am going to update cholesterol tests, replace with:
VAP TM Cholesterol Test (10270X
Quest Diagnostics: Test Menu

[Warrior21]

Wow thanks for all the information. I need to study this and assimilate the info. I've done tons and tons of research already, trust me. I've ben researching this for 3-4 years now. I've decided I will become an endocrinologist due to all the research I've already done. I tend to assimilate it pretty well.

[JanSz]

Originally Posted by Warrior21

Wow thanks for all the information. I need to study this and assimilate the info. I've done tons and tons of research already, trust me. I've ben researching this for 3-4 years now. I've decided I will become an endocrinologist due to all the research I've already done. I tend to assimilate it pretty well.

Do not study to be endocrinologist.
After you finish school you will be brain washed and will not be able to help yourself.

Analysis/paralysis

3-4 years, you are taking too much time.
Study as you go.
Take action now.

[Warrior21]

I appreciate all the information JanSZ. I would be an endo who treats people mostly based on symptoms, not just bloodwork though. I hear that back 30 years ago thats how it used to be and that people were happier with doctors.
I wish I could afford to do all that testing, but I no longer have health insurance. Unfortunately soon I may be homeless. The financial situation is very serious.
I can only afford to buy the cheapest DHEA and 7-keto DHEA I can find. I can afford cortef as it is cheap. But I just received 480 pellets of IsoCort today, so I will be doing about 10 of those daily to see how it works. If I dont see improvement on that within a couple of weeks I'll order the Cortef.
Hopefully the DHEA will help increase IGF-1 and testosterone. I have DIM, calcium d glucarate, and letrozole to combat increased estrogen if I need it because of DHEA.
I will have to exclude the TRT (no health insurance/money) and have to do Armour. I have Armour and plenty of t3 on hand. I will start with Armour 1 grain and keep building up until I cannot tolerate anymore (as of right now I dont get any sides from it anyway).
I'm also going to supplement SAM-e, Tyrosine, and 5-HTP for neurotransmitters.
So here it is all more simplified, let me know what you would add in/change but keep in mind the money restrictions;

IsoCort: 4@ 8am, 2@ noon, 2@ 4pm (If more is needed I'll do 4-3-3)
5-HTP: 100mg 2x daily (morning, afternoon)
Reset A.D.: 1 in the morning, 1 in the afternoon
7-Keto DHEA, DHEA: 50mg of each 2x/daily (morning, afternoon)
Calcium D-Glucarate 500mg daily (morning)
Armour: 2 grain daily (1 grain morning, 1 grain afternoon)

Once I start seeing results from the Armour I will start experimenting with dosages of T3. I will look for signs that it's working (increased sweating, hunger, energy)
If t3 starts working for me, I will try some superdrol (fast acting, strong) I have around the house and look for results within a few days. My brother swells up quickly on that stuff. I only have a little bit so I will have to be conservative. If by 5-7 days it does not work I will wait another couple weeks to try again and see if I'm sensitive to it.
Basically I'm going to take a trial and error approach with relatively cheap drugs that are supposed to work quickly. What do you guys think?

[JanSz]

Originally Posted by Warrior21

I appreciate all the information JanSZ. I would be an endo who treats people mostly based on symptoms, not just bloodwork though. I hear that back 30 years ago thats how it used to be and that people were happier with doctors.
I wish I could afford to do all that testing, but I no longer have health insurance. Unfortunately soon I may be homeless. The financial situation is very serious.
I can only afford to buy the cheapest DHEA and 7-keto DHEA I can find. I can afford cortef as it is cheap. But I just received 480 pellets of IsoCort today, so I will be doing about 10 of those daily to see how it works. If I dont see improvement on that within a couple of weeks I'll order the Cortef.
Hopefully the DHEA will help increase IGF-1 and testosterone. I have DIM, calcium d glucarate, and letrozole to combat increased estrogen if I need it because of DHEA.
I will have to exclude the TRT (no health insurance/money) and have to do Armour. I have Armour and plenty of t3 on hand. I will start with Armour 1 grain and keep building up until I cannot tolerate anymore (as of right now I dont get any sides from it anyway).
I'm also going to supplement SAM-e, Tyrosine, and 5-HTP for neurotransmitters.
So here it is all more simplified, let me know what you would add in/change but keep in mind the money restrictions;

IsoCort: 4@ 8am, 2@ noon, 2@ 4pm (If more is needed I'll do 4-3-3)
5-HTP: 100mg 2x daily (morning, afternoon)
Reset A.D.: 1 in the morning, 1 in the afternoon
7-Keto DHEA, DHEA: 50mg of each 2x/daily (morning, afternoon)
Calcium D-Glucarate 500mg daily (morning)
Armour: 2 grain daily (1 grain morning, 1 grain afternoon)

Once I start seeing results from the Armour I will start experimenting with dosages of T3. I will look for signs that it's working (increased sweating, hunger, energy)
If t3 starts working for me, I will try some superdrol (fast acting, strong) I have around the house and look for results within a few days. My brother swells up quickly on that stuff. I only have a little bit so I will have to be conservative. If by 5-7 days it does not work I will wait another couple weeks to try again and see if I'm sensitive to it.
Basically I'm going to take a trial and error approach with relatively cheap drugs that are supposed to work quickly. What do you guys think?

It is not going to be easy.
Keep us posted.
I wish I knew better way, I would use it myself.

[Warrior21]

What do you think is the main cause of me not responding to steroids? I myself am thinking it is the adrenal fatigue issue. Don't most people treat adrenal fatigue easily. I'm going to try the IsoCort, if it dosent work I can get the HC.
How can anyone improve upon my plan? Keep in mind finances.