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Old 09-18-2009, 07:11 AM
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Default Zyban/Wellbutrin Dissolving in Stomach

Hi, posted this on Definitive Mind as well

I have been on Zyban for depression for about a year now. For the first 8 months it worked great. Then I had some stomach problems from taking too much ibuprofen. Doctor (not my psych) prescribed pariet (ppi which stops acid production in stomach), which I took for a while, but it made the pain worse, so I stopped that.

Anyway, ever since the stomach problem started, the Zyban, which is supposed to be extended release and pass though my stomach and into my intestines, is dissolving in my stomach. I can feel it everytime I take it, as there is a sharp burning pain in my stomach, folllowed by a gnawing pain for a few hours. This is followed by the usual heartburn symptoms. The stomach pain is one thing, but the worst is that the Zyban is no longer working properly, instead of getting an extended release dose, It all dissolves within half hour or so. Needless to say I feel pretty crap. I cannot stop taking it though, as to stop is a disaster, I cannot function without it. I have seen a few gastro doctors about the problem and have had an endoscope of my stomach. Nothing but a bit of gastritis. They have tried ppi's for acid and motilium to move the Zyban though my stomach faster - nothing has worked.

Question is, why is the Zyban dissolving in my stomach, is it because my stomach is too acidic and it is locked in a cycle of producing too much acid, everytime it is hit by the Zyban? I thought Zyban was enterically coated, so that it would not dissolve in an acidic environment at all?

I have been to numerous doctors about this problem and none can fix it, it is getting extemely frustrating. Any thoughts? I have so far not had any ph testing on my stomach.

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Old 09-20-2009, 11:12 AM
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Default Re: Zyban/Wellbutrin Dissolving in Stomach

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