Arachidonic Acid with gear

[cruel.intentions]

Here is an article on it
http://www.molecularnutrition.net/MD...(Dec%2007).pdf
Anyone had any experience with this? Was juice used at the same time?

I was also thinking of getting the oil form of it and injecting it sq to make it more effective.

It makes sense because I do notice alot more growth when I get DOMS. I am thinking of buying it in bulk from abroad what do you think guys, worthy investment or supplement hype?

[steroid500]

i dont know much about it in terms of gear, but i am a food scientist and know arachidonic acid is converted from linoleic acid, and its predominantly found in the brain and nervous system, cell membranes and used in cell signaling. theres been some hype regarding it as an "unhealthy unstaturated fat". in high levels it is postulated to lead to alzeihmers or other disorders.

[cruel.intentions]

hhhm thanks i didn't know the possible negative aspect of it.

[steroid500]

so you got me thinking and i did some research and found this (if your interested):

In the brain arachidonic acid is released from phospholipids by an enzyme called group IVA phospholipase A2 (or PLA2). The scientists lowered PLA2 levels in the Alzheimer mice by genetic engineering. Removal or even partial reduction of PLA2 prevented memory deficits and other behavioral abnormalities in the Alzheimer mice.
"Arachidonic acid likely wreaks havoc in the Alzheimer mice by causing too much excitation, which makes neurons sick. By lowering arachidonic acid levels, we are allowing neurons to function normally," said Dr. Sanchez-Mejia.




Gladstone Institute. 2008. Gladstone scientists identify role of fatty acids in Alzheimer's disease. Pain and Central Nervous System Week. P436.

Arachidonic acid (AA) is a common dietary n-6 polyunsaturated fatty acid that is present in an esterified form in cell membrane phospholipids, and it might be present in the extracellular microenvironment. In particular, AA promotes MAPK activation and mediates the adhesion of MDA-MB-435 breast cancer cells to type IV collagen. However, the signal transduction pathways mediated by AA have not been studied in detail. Our results demonstrate that stimulation of MDA-MB-231 breast cancer cells with AA promotes an increase in the phoshorylation of Src and FAK, as revealed by site-specific antibodies that recognized the phosphorylation state of Src at Tyr-418, and of FAK at tyrosine-397 and in vitro kinase assays. In addition, AA also induces an increase in the migration of MDA-MB-231 cells. In contrast, AA does not induce phosphorylation of FAK and an increase in cell migration of non-tumorigenic epithelial cells MCF10A. Inhibition of Gi/Go proteins, LOX and Src activity prevent FAK activation and cell migration. In conclusion, our results demonstrate, for the first time, that Gi/Go proteins, LOX and Src play an important role in FAK activation and cell migration induced by AA in MDA-MB-231 breast cancer cells.

Napoleon, Navarro-Tito. Robledo, Teresa. Eduardo P, Salazar. 2008. Arachidonic acid promotes FAK activation and migration in MDA-MB-231 breast cancer cells. Experimental Cell Research. 314(18). p3340-3355.

A report released by the Cornucopia Institute reveals adverse health effects of the synthetically produced fatty acids docosahexaenoic acid (DHA) and arachidonic acid (ARA) found in infant formulas. In some cases symptoms such as vomiting and diarrhea were reported after consuming DHA/ARA formulas whereas in other cases infants had to be hospitalized for treatment of severe dehydration and seizures.


2008. A Tiny Bundle of Joy...A Big Bundle of Paperwork.Issue 48. P32. Mothering.



granted, AA is an EFA, but in such a minuet amount. More research is still needs to be done regarding increased AA levels and the effects it has. AA is found naturally in egg yolks and meats, and it is also synthesised by the body from linoleic acid (omega-6). Personally, i would not take a suppliment that promotes AA use or claims to have high levels of AA. i mean, juice is one thing: we know the effects it will have. but AA just seems like playing with fire.