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Steroid Forum: This is a discussion on Arimidex VS femmera within the Anabolic Steroids forums, part of the extensive steroid information at MESO-Rx; What do you bros prefer to use during cycles? What are the cons and pros. What about proviron ? I ...

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Old 10-10-2004, 04:27 PM
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Default Arimidex VS femmera

What do you bros prefer to use during cycles? What are the cons and pros.

What about proviron?


I usually just use a regular nolvadex/clomid for PCT. But this next cycle is gonna be a big one. I think I will need a little something more.
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Old 10-11-2004, 12:38 AM
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bump
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Old 10-11-2004, 12:57 AM
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Bump to the top.


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Old 10-11-2004, 12:32 PM
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Huge Bump Bigkarch,

Super reading man, thanks for the contribution. In the end, Arimidex is the winner, that's cool.

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Old 10-11-2004, 02:52 PM
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Hi BigKarch,

I don't know you, but after reading your post did some research. I have seen many of the studies your post references. Most of us who research all have seen them however retaining all the info is not that easy.

Anyway the part about: "Anastrozol raising IGf1 & shows a trend towards increasing IGF2." I found the study you referenced using Medline & it is talking about short term anastrozole treatment. Further your post did not mention this quote from the same study: "We have previously shown that letrozole (a different type of NSS-AI) modifies blood IGF-1 levels, and the results of this study of the biological effects of anastrozole on the components of the IGF system confirm our previous observations." In other words a previous letrozole study shows the same short term outcome. At this time I have not searched for that study. If I have time to locate it today I will try & post that study on letrozole.

I questioned the HCG regamin part of your post as well? I am pressed for time so if I question anything in error I am sorry. Your post did not mention starting HCG while on the cycle? I think your post read that way, not enough time to double check? Anyway I always use it durring cycle to keep the boys size up & think if used post cycle that it can harm the recovery. Post cycle you just want to use your anti-e's. This worked well for me.

I read the part about what steroids aromatize & was left scratching my head. Flouxymesterone was given to children to help promote growth in linear height. I know Oxandrolone is the main steroid used besides GH in this area of growth promotion study, But we are talking steroids & your post said Flouxy aromatized? I do recall reading some post on the internet saying the same thing about Flouxymesterone or a study but, I did much research & decided to count that read as an error. I may be wrong & if so welcome you to enliten me.

In general I liked the post & it made me do some research. Great deal about your post was very interesting like the Bromo & Cabergoline parts as well as the info on .5 milligram anastrozole being ill suited to raise testosterone levels but still blocking estrogen levels. I do question that part though about .5 mg anastrozole not being able to raise Testosterone.(I don't question you BigKarch I question the study) I will look for studies on that as well. Time if only we all had more of it.

Again I in general liked the post it made me think & this is not ment as an attack on you BigKarch. I would like to continue this dialog with anyone who will help shed some lite by posting more studies or quotes from studies.

Best to you BigKarch,
focus

P.S. I forgot to mention I liked the part on Nolvadex & the effect it may have on progesterone receptors. (I was not aware of this now I am) Loved the quote: Note I didn't say that these other steroids convert to progesterone, but rather that they have progesterone effects. (I posted bad info in a rush in a different thread on this as I said "raised" progesterone.) I printed your whole post so don't take me wrong BicKarch I liked it as a whole

Last edited by focus; 10-12-2004 at 09:18 AM.
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Old 10-11-2004, 03:16 PM
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Default Posting of my research on the studies as promised above if I had time.

The aromatase inhibitor letrozole in advanced breast cancer: effects on serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 levels.

Bajetta E, Ferrari L, Celio L, Mariani L, Miceli R, Di Leo A, Zilembo N, Buzzoni R, Spagnoli I, Martinetti A, Bichisao E, Seregni E.

Medical Oncology B Division, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.

Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 levels were measured in two groups of postmenopausal women with advanced breast cancer, who received the aromatase inhibitor letrozole 0.5 or 2.5 mg p.o. once daily. Blood samples were obtained from 15 patients in each dose group at baseline, and one and three months after starting therapy. Circulating IGF-I and IGFBP-3 concentrations were determined by means of radioimmunoassay. In both dosage groups a statistically significant increase in the IGF-I levels was observed during three months of letrozole treatment (P=0.003). In addition, the multiple testing procedure yielded in the whole patient population a significant result in the comparison between mean IGF-I values after three months of therapy and those observed at baseline (P=0.004), the estimated average increase being of 24%. No significant result was obtained in the analysis for the dose effect (P=0.077) and for the time x dose interaction (P=0.208). Circulating IGFBP-3 levels did not appear to be affected by letrozole treatment in either of the dose groups. This is the first report concerning the short-term effects of letrozole on components of the IGF system in breast cancer patients; further investigations are warranted in order to confirm these preliminary data.

Pediatrics. 1993 Apr;91(4):716-20. Related Articles, Links


Long-term results of treatment with low-dose fluoxymesterone in constitutional delay of growth and puberty and in genetic short stature.

Strickland AL.

Spartanburg Regional Medical Center, SC.

This prospective study was designed to assess growth response, side effects, other possible long-term effects, and final adult height in boys treated with the oral androgen, fluoxymesterone. From 1973 to 1984, eighty-two short boys (71 with constitutional delay of growth and puberty [CDGP] and 11 with genetic short stature [GSS]) were treated with daily oral doses of 2.5 mg of fluoxymesterone from 6 to 60 months. Final height assessment was made from 1989 to 1991. A group of 34 untreated boys (26 with CDGP and 8 with GSS) were also followed to assess the accuracy of the Greulich-Pyle and Bayley-Pinneau (GP-BP) and sexual maturity index height prediction methods. During treatment, each patient had a 1.7- to 2.5-fold increase in linear growth velocity. Accelerated velocity (over baseline) continued as long as the bone age was less than 14 years. No adverse androgenic effects (or undue acceleration of puberty) were observed. Final height exceeded pretreatment predictions for CDGP + GSS by 6.1 +/- 3.5 (SD) cm (GP-BP) and 5.4 +/- 3.2 cm (sexual maturity index). It is concluded that a daily oral dose of 2.5 mg of fluoxymesterone can be used to accelerate linear growth in boys with CDGP and GSS when needed to alleviate emotional problems secondary to slow growth and short stature without fear of compromising final adult height.

PMID: 8464656 [PubMed - indexed for MEDLINE]

IMHO they picked this steroid because it does not raise estrogen you did mention at higher dose & like I said I read something on that, but think it is false and a repeated to often as fact.

focus

Last edited by focus; 10-11-2004 at 03:22 PM.
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Old 10-11-2004, 11:03 PM
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Bigkarch,

On the Fluoxymesterone issue: The studty I posted has a quote: "Final height exceeded pretreatment predictions for CDGP + GSS by 6.1 +/- 3.5 (SD) cm (GP-BP) and 5.4 +/- 3.2 cm" IMHO this would not be the outcome if the Fluoxy aromatized. IMHO the fact Fluoxy supressed the natural hormone level some and kept a androgen present to promote growth allowed the extra height without the estrogen advancing bone age. You are correct it was low dose Fluoxy used in the study. I still believe that high doses of Fluoxy do not aromatize till proven different. (If you can find a study on the conversion of high ammounts of Fluoxy to estrogen please post) I have seen the same thing you read on Fluoxy in high dose out on the internet. I think that information is wrong.

When I read the post again it mentioned also that Boldenone was in with the "worst offenders" talking about aromatization to estrogen yet Boldenone is just Equipoise & just like Deca as the post mentions will aromatize. Deca "yeah it aromatises" IMHO both not a worst offender though. In a cycle both Deca & Bold. seem to act as a worst offender because of progesteronic effects, but neither are major converters to estrogen.

On the HCG I do not take it through the whole cycle. I should have been more clear on that. I take it at the end of 2nd or 3rd week on a cycle I forget which week without researching again. (This is because at the 2nd or 3rd week in the body will still react well to HCG) Then I take HCG my last two weeks of cycle. I never use more than 500mg per my Doctors warning. I guess as you state I should take it all days of the week or at least 5 straight. I believe I did three straight then every other day last two weeks. I took Adex whole cycle & upped the adex while on HCG & just post cycle Adex seemed to work well for me. I don't use HCG post cycle as it tries to increases estrogen levels & is thus counter productive. My PCT ends with just Adex & tapers down Adex till I am at just Tues.-Thurs. .5mg Adex so I don't get any rebound I hope.

I went back & read the Femara (Letrozol) thing & found you were correct. I read the post fast you did mention conflicting studies & specifically did mention the Femara IGF1 conection. I need to point out both Anastrozole & Femara have those same type conflicting studdies.

Great thread this is becoming with all the studies being posted.

focus

Last edited by focus; 10-11-2004 at 11:32 PM.
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Old 10-12-2004, 02:18 AM
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excellent discussion...thanks for the info
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Old 10-12-2004, 08:55 AM
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Default Re:

Quote:
Originally Posted by Bigkarch
Yes hcg will increase estrogen levels but if you use in only for 7-10 days, it wont do any harm...I also advocate using nolva and or clomid or even dex during that period of hcg usage because of that.

One thing you said that you use dex only for pct. Why not nolva and or clomid? I dont believe dex will help jump start your natural test production as clomid and nolva are known to.

BigKarch,

That may be sound advice about using both Nolvadex & Arimidex at the end of a cycle & I believe if Nolvadex is used at the end only you limit its side effects. I have used Nolvadex at the end of my cycle with Arimidex in the past. (No More) Nolvadex has a warning on its label. Because of this warning I am trying to downplay Nolvadex use. IMHO Arimidex does work better at jump starting testosterone than given credit for though. 8) Hayes FJ, et al. "Aromatase inhibition in the human male reveals a hypothalamic site of estrogen feedback." J Clin Endocrinol Metab 2000 Sep;85(9):3024-6

9) Mauras N, et al. "Estrogen suppression in males: metabolic effects." J Clin Endocrinol Metab. 2001 Apr;86(4):1836-8

The warnings for Nolvadex:

Side Effects of Tamoxifan:
Along with its needed effects, a medicine may cause some unwanted effects. Some side effects will have signs or symptoms that you can see or feel. Your doctor will watch for others by doing certain tests.
Also, because of the way this medicine acts on the body, there is a chance that it might cause other unwanted effects that may not occur until months or years after the medicine is used. Tamoxifen increases the chance of cancer of the uterus (womb) in some women taking it. Tamoxifen may cause blockages to form in a vein, lung, or brain. In women, tamoxifen may cause cancer or other problems of the uterus (womb). It also causes liver cancer in rats. In addition, tamoxifen has been reported to cause cataracts and other eye problems. Discuss these possible effects with your doctor.
Check with your doctor as soon as possible if any of the following side effects occur:
For both females and males
Less common or rare
Anxiety; blistering, peeling, or loosening of skin and mucous membranes; blurred vision; chest pain; confusion; cough; dizziness; fainting; fast heartbeat; lightheadedness; pain or swelling in legs; shortness of breath or trouble breathing; weakness or sleepiness; yellow eyes or skin
For females only
Less common or rare
Change in vaginal discharge; chills ; fever; hoarseness; lower back or side pain; pain or feeling of pressure in pelvis; pain, redness, or swelling in your arm or leg; painful or difficult urination ; rapid shallow breathing; skin rash or itching over the entire body; sweating ; vaginal bleeding; wheezing
For females and males
Frequency not determined
Bloating; constipation; darkened urine; diarrhea; difficult breathing; indigestion; itching; joint or muscle pain; large, hard skin blisters; large hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, and sex organs; loss of appetite; nausea; pain in stomach or side, possibly radiating to the back; red, irritated eyes; red skin lesions, often with a purple center; sore throat; sores, ulcers or white spots in mouth or on lips; unusual tiredness or weakness; vomiting
This medicine may also cause the following side effect that your doctor will watch for:
For both females and males
Less common or rare
Cataracts in the eyes or other eye problems; liver problems
Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
For both females and males
Less common
Bone pain; headache; nausea and/or vomiting (mild); skin rash or dryness
For females only
More common
Absent, missed, or irregular periods; confusion; decrease in amount of urine; feeling of warmth redness of the face, neck, arms and occasionally, upper chest; lower back or side pain; menstrual changes; nausea; noisy, rattling breathing; painful or difficult urination; rapid, shallow breathing; skin changes; stopping of menstrual bleeding; swelling of fingers, hands, feet, or lower legs; troubled breathing at rest; vaginal bleeding; weight gain; weight loss; white or brownish vaginal discharge
Less common or rare
Abdominal cramps; black, tarry stools ; bleeding gums; blood in urine or stools; Bluish color changes in skin color ; discouragement; feeling sad or empty; irritability; itching in genital area; lack of appetite; loss of interest or pleasure; pain; pinpoint red spots on skin; stomach or pelvic discomfort, aching or heaviness; swelling ; trouble concentrating; trouble sleeping; unusual bleeding or bruising
For males only
Less common
decreased interest in sexual intercourse; inability to have or keep an erection; loss in sexual ability, desire, drive, or performance
This medicine may infrequently cause hair thinning or partial loss of hair.
Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.

I am a bit put off by the warning on eye health,

Seperate issue: Fluoxymesterone

J Clin Endocrinol Metab 1977 Jan;44(1):121-9 (ISSN: 0021-972X)
Jones TM; Fang VS; Landau RL; Rosenfield RL
Long term daily administration of fluoxymesterone (9alpha-fluoro-17alpha-methyl-11beta, 17beta-dihydroxyandrost-4-en-3-one) was associated with a modest suppression of sperm production and a profound suppression of testosterone levels in the absence of significant effects on plasma gonadotropin levels. Nine normal male volunteers took either 10, 20, or 30 mg of fluoxymesterone daily for twelve weeks. Plasma samples were obtained for testosterone, estrogen, LH and FSH levels at biweekly intervals before, during and for up to 12 weeks after fluoxymesterone treatment. Samples were obtained for dehydroepiandrosterone sulfate, testosterone binding globulin and free testosterone assays at representative times before, during and after treatment. Although lower sperm counts were observed at several points during both the treatment and follow up periods, significant consistent suppression of spermatogenesis could not be demonstrated. Reduced plasma testosterone levels were seen within 24 h after beginning fluoxymesterone, and further reductions were noted throughout the treatment period. Changes in plasma estrogen levels did not correlate with fluoxymesterone administration. Neither plasma LH nor plasma FSH levels were significantly altered by fluoxymesterone. A short term study utilizing a single dose of fluoxymesterone yielded similar findings. It is proposed that fluoxymesterone has a local effect on the Leydig cell which is not mediated by gonadotropins.

It is mt belief this study started the wrong thinking on Fluoxy aromatization. The first Bold area points out "Changes in plasma estrogen levels did not correlate with Fluoxy administration" This may have lead some to believe it was converting to estrogen. IMHO you can not make that conclusion from this study. Somebody out on the internet I believe did. The last bold part is how Fluoxy has a local effect to suppress Testosterone production. This study did not say no change took place in estrogen level just that it was not correlated to the Fluoxy. That means estrogen may have been correlated to the lower Testosterone level from Fluoxy use? Who knows what it means? I would say the structure of Fluoxy can not convert to Estrogen & the Child height study backs that up. I may be wrong as stated & I welcome that being pointed out,

focus

Last edited by focus; 10-12-2004 at 10:45 AM.
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Old 10-12-2004, 11:39 AM
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Default This is ment to copliment BigKarch's post

The info below is not my own, but coppied from the Web:
Progesterone induced gyno a misconception?
To cear up a few misconceptions about progesterone and gynecomastia.

Their is absolutely no steroid that aromatizes into progesterone. The reason for this is that progesteron does not have an aromatic A ring. So toss that myth out the window. Tren? Deca? Sorry but it just doesn't happen.

Trenbolone \ Deca bind pretty well to the PR. They are progestins in their own right without undergoing structural changes, but their affinity is MUCH weaker than progesterone itself. Even more so when nandrolone is reduced by 5-alpha reductase into DHN. Their is a small chance of progestogenic activity that could aid in manifesting a mass in the mammry IF estrogen is present in supraphysiological amounts, without proper ratio to testosterone but I have never see a documented case of progestogenic gynecomastia. The reason for this is that the PR has two isoforms. The PR-A and PR-B. PR-B mediates stimulatory effects of progestins; PR-A which is bound with progestins or anti-progestins inhibits PR-B, and PR-A is dominant,. The response to progesterone is determined by the relative expression of the two isoforms.

There is a direct relationship between the PR isoforms and steroid concentrations an this direct relationship suggests high progesterone concentrations, but this will induce the expression of PR-A, which represses transcription of PR-B, which in turn supresses PR function and progestin effect
With initial administration of nandrolone or it's dirivitives, I could see an expression of PR-B but a rapid rise in PR-A will ultimately supress the function of the PR. IMO, you would need a high ratio of the two before concerns, and this is a bit more of a possiblity with the begining of administration. In this time of vulnerability, rest assured in aromatase inhibitors as progesterone is an E2 agonist so the utilization of an AI will help. I personally don't think the concern is warranted though

Their are 4 combinations of hormones that cause gyno- Estrogen, Progesterone, Prolactin, and IGF. Nandrolone is a weak progestin, which agonizes the PRL, it also raises IGF. Progesterone induced gyno is not really of a concern given binding affinity to the PR and the mechanism of the two isoforms. The production of prolactin is a deffinate risk. Not only can it be an inductor for gyno along side estrogen, IGF, and pogesterone; this chance is increased as prolactn lowers testosterone. So you need to make sure to take proper precautions to not only keep estrogen in check, but prolactin as well.

bromo is a prolactin inhibitor, as it's a dopamine agonist. Dopamine regulates prolactin. Bromo, dostinex, pergolide, and alike drugs have no direct effect over progesterone

Just to add. B6 is the safest way to help control prolactin. This is recommended before taking the step to a power drug like bromo.

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anastrozole , arimidex , aromatase , cabergoline , cycle , dbol , deca , dostinex , estrogen , first cycle , gynecomastia , gyno , hcg , hrt , methyltestosterone , nandrolone , nolvadex , progesterone , proviron , test 400 , testosterone , tren , trenbolone

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